Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications

• Autor(a) principal: Barbosa, Karla A.
• Data de Publicação: 2022
• Outros Autores: Rodrigues, Isabella C.P., Tamborlin, Letícia [UNESP], Luchessi, Augusto D. [UNESP], Lopes, Éder S.N., Gabriel, Laís P.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.jmrt.2022.03.136; http://hdl.handle.net/11449/240350
• topic: Centrifugal spinning; Drug release; Polylactic acid; Scaffold; Wound dressing

Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.