Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications

Detalhes bibliográficos
Autor(a) principal: Barbosa, Karla A.
Data de Publicação: 2022
Outros Autores: Rodrigues, Isabella C.P., Tamborlin, Letícia [UNESP], Luchessi, Augusto D. [UNESP], Lopes, Éder S.N., Gabriel, Laís P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.jmrt.2022.03.136
http://hdl.handle.net/11449/240350
Resumo: Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.
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spelling Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applicationsCentrifugal spinningDrug releasePolylactic acidScaffoldWound dressingPolymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.School of Applied Sciences University of Campinas, São PauloSchool of Mechanical Engineering University of Campinas, São PauloInstitute of Biosciences São Paulo State University, São PauloInstitute of Biosciences São Paulo State University, São PauloUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Barbosa, Karla A.Rodrigues, Isabella C.P.Tamborlin, Letícia [UNESP]Luchessi, Augusto D. [UNESP]Lopes, Éder S.N.Gabriel, Laís P.2023-03-01T20:13:12Z2023-03-01T20:13:12Z2022-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3273-3282http://dx.doi.org/10.1016/j.jmrt.2022.03.136Journal of Materials Research and Technology, v. 18, p. 3273-3282.2238-7854http://hdl.handle.net/11449/24035010.1016/j.jmrt.2022.03.1362-s2.0-85132858529Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Materials Research and Technologyinfo:eu-repo/semantics/openAccess2023-03-01T20:13:12Zoai:repositorio.unesp.br:11449/240350Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:57:26.754226Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
title Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
spellingShingle Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
Barbosa, Karla A.
Centrifugal spinning
Drug release
Polylactic acid
Scaffold
Wound dressing
title_short Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
title_full Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
title_fullStr Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
title_full_unstemmed Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
title_sort Rotary jet-spun curcumin-loaded poly L-lactic acid membranes for wound-healing applications
author Barbosa, Karla A.
author_facet Barbosa, Karla A.
Rodrigues, Isabella C.P.
Tamborlin, Letícia [UNESP]
Luchessi, Augusto D. [UNESP]
Lopes, Éder S.N.
Gabriel, Laís P.
author_role author
author2 Rodrigues, Isabella C.P.
Tamborlin, Letícia [UNESP]
Luchessi, Augusto D. [UNESP]
Lopes, Éder S.N.
Gabriel, Laís P.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Barbosa, Karla A.
Rodrigues, Isabella C.P.
Tamborlin, Letícia [UNESP]
Luchessi, Augusto D. [UNESP]
Lopes, Éder S.N.
Gabriel, Laís P.
dc.subject.por.fl_str_mv Centrifugal spinning
Drug release
Polylactic acid
Scaffold
Wound dressing
topic Centrifugal spinning
Drug release
Polylactic acid
Scaffold
Wound dressing
description Polymeric membranes are good alternatives to conventional dressings for wound-healing applications, owing to their high porosity and surface area. Incorporation of bioactive particles into membranes can improve therapeutic outcomes of dressings. Curcumin has been reported as a bioactive particle with antioxidant and wound-healing potential, as well as therapeutic action against diabetes, inflammation, and cancer. However, few techniques have been explored to efficiently produce curcumin-incorporated dressings on a large scale. Rotary jet spinning (RJS) is a membrane processing technique that has gained attention for its high production rate of fibers. In this study, we aimed to produce and characterize poly(L-lactic acid) (PLLA)-based RJS membranes incorporated with curcumin particles (PLLA-Curc) for wound-treatment suitability. We produced membranes with fiber diameters less than 10 μm. The membranes demonstrated thermal stability, a hydrophobic profile, adequate mechanical resistance for topical application, low degradation rates, and a marked release of curcumin over 6 h, followed by a continuous-release profile. In addition, PLLA and PLLA-Curc membranes showed cytocompatibility with fibroblasts. In summary, RJS is an efficient technique to obtain membranes incorporated with curcumin that have potential for wound treatment as non-adherent topical dressings.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-01
2023-03-01T20:13:12Z
2023-03-01T20:13:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.jmrt.2022.03.136
Journal of Materials Research and Technology, v. 18, p. 3273-3282.
2238-7854
http://hdl.handle.net/11449/240350
10.1016/j.jmrt.2022.03.136
2-s2.0-85132858529
url http://dx.doi.org/10.1016/j.jmrt.2022.03.136
http://hdl.handle.net/11449/240350
identifier_str_mv Journal of Materials Research and Technology, v. 18, p. 3273-3282.
2238-7854
10.1016/j.jmrt.2022.03.136
2-s2.0-85132858529
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Materials Research and Technology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3273-3282
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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