Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Renato Simões
Data de Publicação: 2004
Outros Autores: Scarano, Wellerson Rodrigo, Góes, Rejane Maira [UNESP], Taboga, Sebastião Roberto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/224602
Resumo: The flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed an increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed. as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In conclusion, the flutamide treatment exerts tissue effects on the lateral prostate, promoting stroma/epithelium alterations.
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spelling Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapyFlutamide, antiandrogen, secretory cellsLateral prostateThe flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed an increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed. as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In conclusion, the flutamide treatment exerts tissue effects on the lateral prostate, promoting stroma/epithelium alterations.Department of Cell Biology Institute of Biology UNICAMP, CP 6109, 13084-971, Campinas, SPLab. of Microscopy and Microanalysis Department of Biology IBILCE/UNESP, 15054-000, Sao Jose do Rio Preto, SPDepartamento de Biologia IBILCE/UNESP, Rua Cristovao Colombo, 2265, Sao Jose do Rio Preto, SPLab. of Microscopy and Microanalysis Department of Biology IBILCE/UNESP, 15054-000, Sao Jose do Rio Preto, SPDepartamento de Biologia IBILCE/UNESP, Rua Cristovao Colombo, 2265, Sao Jose do Rio Preto, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Cordeiro, Renato SimõesScarano, Wellerson RodrigoGóes, Rejane Maira [UNESP]Taboga, Sebastião Roberto [UNESP]2022-04-28T20:01:30Z2022-04-28T20:01:30Z2004-06-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article21-30Biocell, v. 28, n. 1, p. 21-30, 2004.0327-9545http://hdl.handle.net/11449/2246022-s2.0-2542458436Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiocellinfo:eu-repo/semantics/openAccess2024-04-11T19:33:50Zoai:repositorio.unesp.br:11449/224602Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:24:02.049849Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
spellingShingle Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
Cordeiro, Renato Simões
Flutamide, antiandrogen, secretory cells
Lateral prostate
title_short Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_full Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_fullStr Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_full_unstemmed Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
title_sort Tissue alterations in the Guinea pig lateral prostate following antiandrogen flutamide therapy
author Cordeiro, Renato Simões
author_facet Cordeiro, Renato Simões
Scarano, Wellerson Rodrigo
Góes, Rejane Maira [UNESP]
Taboga, Sebastião Roberto [UNESP]
author_role author
author2 Scarano, Wellerson Rodrigo
Góes, Rejane Maira [UNESP]
Taboga, Sebastião Roberto [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Cordeiro, Renato Simões
Scarano, Wellerson Rodrigo
Góes, Rejane Maira [UNESP]
Taboga, Sebastião Roberto [UNESP]
dc.subject.por.fl_str_mv Flutamide, antiandrogen, secretory cells
Lateral prostate
topic Flutamide, antiandrogen, secretory cells
Lateral prostate
description The flutamide antiandrogenic effects on the Guinea pig male prostate morphology in puberal, post-puberal and adult ages were evaluated in the present study. Daily-treated group animals received flutamide subcutaneous injection at a dose of 10 mg/Kg body weight for 10 days. The control group animals received a pharmacological vehicle under the same conditions. The lateral prostate was removed, fixed and processed for light and transmission electron microscopy. The results revealed an increase of the acinus diameter in the treated puberal animals and straitness in the stromal compartment around the acini. The epithelial cells exhibited cubic phenotype. In the post-puberal and adult animals, a decrease of the acinus diameter was observed. as well as an increase of the smooth muscle layer and presence of the folds at epithelium. The ultrastructural evaluation of the secretory cells in the treated group demonstrated endomembrane enlargement, mainly in the rough endoplasmic reticulum and Golgi apparatus. In addition, a decrease of the microvilli and alterations in the distribution patterns and density of the stromal fibrillar components were observed. In conclusion, the flutamide treatment exerts tissue effects on the lateral prostate, promoting stroma/epithelium alterations.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-07
2022-04-28T20:01:30Z
2022-04-28T20:01:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Biocell, v. 28, n. 1, p. 21-30, 2004.
0327-9545
http://hdl.handle.net/11449/224602
2-s2.0-2542458436
identifier_str_mv Biocell, v. 28, n. 1, p. 21-30, 2004.
0327-9545
2-s2.0-2542458436
url http://hdl.handle.net/11449/224602
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biocell
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21-30
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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