Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca de teses e dissertações da Universidade de Passo Fundo (BDTD UPF) |
Texto Completo: | http://tede.upf.br/jspui/handle/tede/1440 |
Resumo: | Intracerebral hemorrhage cases illustrate one of the diseases with high incidence, high mortality, and the ability to result in loss of human dignity, with a large number of survivors living with severe disabilities. The elderly population is especially susceptible to suffering by the loss of autonomy after an acute illness since the acute event aggregates to other biological and cultural factors of aging. With aging of the population, it is likely that the number of patients with noninfectious chronic diseases, including spontaneous cerebral hemorrhage, will rise. This is a complex public health problem, not only by its high incidence but due to the high associated mortality and the high incidence of severe disability among survivors. We have evaluated the effect of the pretreatment with Spirulina platensis for a period of 30 days in a rat model of cerebral hemorrhage. We hypothesized that Spirulina platensis and its major protein component, phycocyanin C, could mitigate the secondary cellular injury in the perilesional zone, through its antioxidant, anti-inflammatory and iron chelator activity, by interacting with cellular mechanisms of neuronal death. Experimental studies are required to prove its potential neuroprotective effect, as well as to determine the optimum period of treatment and appropriate dose |
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Bertolin, Telma Elita40751708020http://lattes.cnpq.br/980879342589463300198451385http://lattes.cnpq.br/1663818903578102Almeida, Timóteo Abrantes de Lacerda2018-06-22T19:45:24Z2016-04-01ALMEIDA, Timóteo Abrantes de Lacerda. Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental. 2016. 44 f.Dissertação (Mestrado em Envelhecimento Humano) - Universidade de Passo Fundo, Passo Fundo, RS, 2016.http://tede.upf.br/jspui/handle/tede/1440Intracerebral hemorrhage cases illustrate one of the diseases with high incidence, high mortality, and the ability to result in loss of human dignity, with a large number of survivors living with severe disabilities. The elderly population is especially susceptible to suffering by the loss of autonomy after an acute illness since the acute event aggregates to other biological and cultural factors of aging. With aging of the population, it is likely that the number of patients with noninfectious chronic diseases, including spontaneous cerebral hemorrhage, will rise. This is a complex public health problem, not only by its high incidence but due to the high associated mortality and the high incidence of severe disability among survivors. We have evaluated the effect of the pretreatment with Spirulina platensis for a period of 30 days in a rat model of cerebral hemorrhage. We hypothesized that Spirulina platensis and its major protein component, phycocyanin C, could mitigate the secondary cellular injury in the perilesional zone, through its antioxidant, anti-inflammatory and iron chelator activity, by interacting with cellular mechanisms of neuronal death. Experimental studies are required to prove its potential neuroprotective effect, as well as to determine the optimum period of treatment and appropriate doseA hemorragia cerebral ilustra uma das doenças com alta incidência, alta mortalidade, e com a capacidade de resultar em perda da dignidade humana, com grande número dos sobreviventes vivendo com incapacidades graves. A população idosa é especialmente susceptível ao sofrimento gerado pela perda de autonomia após um agravo agudo à saúde, uma vez que a esse evento agudo se agregam outros farores biológicos e culturais decorrentes do envelhecimento. Com o envelhecimento populacional, é provável que o número de pacientes com doenças crônicas não infecciosas, dentre elas, a hemorragia cerebral espontânea. Trata-se de um problema de saúde pública, não somente pela alta incidência, mas devido a alta mortalidade associada e à grande incidência de incapacidade grave dentre os sobreviventes. Avaliamos o efeito do pré-tratamento com Spirulina platensis por um período de 30 dias em modelo experimental de hemorragia cerebral induzida por colagenase em ratos. Nós levantamos a hipótese de que a Spirulina platensis, bem como seu principal componente proteico, a ficocianina C, poderiam atenuar a lesão celular na zona perilesional, através de suas propriedades antioxidantes, anti-inflamatórias e quelante de ferro, através da atuação nos mecanismos celulares de morte neuronal no dano cerebral secundário. Estudos experimentais são necessários para provarem o seu potencial neuroprotetor nessa patologia, bem como para determinar o período ideal de tratamento e a dose adequadaSubmitted by Aline Rezende (alinerezende@upf.br) on 2018-06-22T19:45:24Z No. of bitstreams: 1 2016TimoteoAbrantesdeLacerdaAlmeida.pdf: 375162 bytes, checksum: 8362024ca045c0298b66bf2962a88f24 (MD5)Made available in DSpace on 2018-06-22T19:45:24Z (GMT). No. of bitstreams: 1 2016TimoteoAbrantesdeLacerdaAlmeida.pdf: 375162 bytes, checksum: 8362024ca045c0298b66bf2962a88f24 (MD5) Previous issue date: 2016-04-01application/pdfporUniversidade de Passo FundoPrograma de Pós-Graduação em Envelhecimento HumanoUPFBrasilFaculdade de Educação Física e Fisioterapia – FEFFHemorragiaAcidentes vasculares cerebraisNeurologiaCIENCIAS DA SAUDE::SAUDE COLETIVAAvaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimentalAssessment of potential neuroprotective of Spirulina platensis in experimental intracerebral hemorrhage modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-9132566411690049154500500600-6530859672398272641-6173167103754495199info:eu-repo/semantics/openAccessreponame:Biblioteca de teses e dissertações da Universidade de Passo Fundo (BDTD UPF)instname:Universidade de Passo Fundo (UPF)instacron:UPFLICENSElicense.txtlicense.txttext/plain; charset=utf-81940http://tede.upf.br:8080/jspui/bitstream/tede/1440/1/license.txte0faded76e3df80302a4a0fb3f2bb5f3MD51ORIGINAL2016TimoteoAbrantesdeLacerdaAlmeida.pdf2016TimoteoAbrantesdeLacerdaAlmeida.pdfapplication/pdf375162http://tede.upf.br:8080/jspui/bitstream/tede/1440/2/2016TimoteoAbrantesdeLacerdaAlmeida.pdf8362024ca045c0298b66bf2962a88f24MD52tede/14402018-06-22 16:45:24.751oai:tede.upf.br: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Biblioteca Digital de Teses e DissertaçõesPUBhttp://tede.upf.br/oai/requestbiblio@upf.br || bio@upf.br || cas@upf.br || car@upf.br || lve@upf.br || sar@upf.br || sol@upf.br || upfmundi@upf.br || jucelei@upf.bropendoar:2018-06-22T19:45:24Biblioteca de teses e dissertações da Universidade de Passo Fundo (BDTD UPF) - Universidade de Passo Fundo (UPF)false |
dc.title.por.fl_str_mv |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
dc.title.alternative.eng.fl_str_mv |
Assessment of potential neuroprotective of Spirulina platensis in experimental intracerebral hemorrhage model |
title |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
spellingShingle |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental Almeida, Timóteo Abrantes de Lacerda Hemorragia Acidentes vasculares cerebrais Neurologia CIENCIAS DA SAUDE::SAUDE COLETIVA |
title_short |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
title_full |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
title_fullStr |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
title_full_unstemmed |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
title_sort |
Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental |
author |
Almeida, Timóteo Abrantes de Lacerda |
author_facet |
Almeida, Timóteo Abrantes de Lacerda |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Bertolin, Telma Elita |
dc.contributor.advisor1ID.fl_str_mv |
40751708020 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9808793425894633 |
dc.contributor.authorID.fl_str_mv |
00198451385 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1663818903578102 |
dc.contributor.author.fl_str_mv |
Almeida, Timóteo Abrantes de Lacerda |
contributor_str_mv |
Bertolin, Telma Elita |
dc.subject.por.fl_str_mv |
Hemorragia Acidentes vasculares cerebrais Neurologia |
topic |
Hemorragia Acidentes vasculares cerebrais Neurologia CIENCIAS DA SAUDE::SAUDE COLETIVA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::SAUDE COLETIVA |
description |
Intracerebral hemorrhage cases illustrate one of the diseases with high incidence, high mortality, and the ability to result in loss of human dignity, with a large number of survivors living with severe disabilities. The elderly population is especially susceptible to suffering by the loss of autonomy after an acute illness since the acute event aggregates to other biological and cultural factors of aging. With aging of the population, it is likely that the number of patients with noninfectious chronic diseases, including spontaneous cerebral hemorrhage, will rise. This is a complex public health problem, not only by its high incidence but due to the high associated mortality and the high incidence of severe disability among survivors. We have evaluated the effect of the pretreatment with Spirulina platensis for a period of 30 days in a rat model of cerebral hemorrhage. We hypothesized that Spirulina platensis and its major protein component, phycocyanin C, could mitigate the secondary cellular injury in the perilesional zone, through its antioxidant, anti-inflammatory and iron chelator activity, by interacting with cellular mechanisms of neuronal death. Experimental studies are required to prove its potential neuroprotective effect, as well as to determine the optimum period of treatment and appropriate dose |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-04-01 |
dc.date.accessioned.fl_str_mv |
2018-06-22T19:45:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
ALMEIDA, Timóteo Abrantes de Lacerda. Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental. 2016. 44 f.Dissertação (Mestrado em Envelhecimento Humano) - Universidade de Passo Fundo, Passo Fundo, RS, 2016. |
dc.identifier.uri.fl_str_mv |
http://tede.upf.br/jspui/handle/tede/1440 |
identifier_str_mv |
ALMEIDA, Timóteo Abrantes de Lacerda. Avaliação do potencial neuroprotetor da Spirulina platensis em modelo de hemorragia intracerebral experimental. 2016. 44 f.Dissertação (Mestrado em Envelhecimento Humano) - Universidade de Passo Fundo, Passo Fundo, RS, 2016. |
url |
http://tede.upf.br/jspui/handle/tede/1440 |
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por |
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por |
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openAccess |
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Universidade de Passo Fundo |
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Programa de Pós-Graduação em Envelhecimento Humano |
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UPF |
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Brasil |
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Faculdade de Educação Física e Fisioterapia – FEFF |
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Universidade de Passo Fundo |
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