Importance of bacterial endotoxin (LPS) in endodontics
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572004000200002 |
Resumo: | New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion. |
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Importance of bacterial endotoxin (LPS) in endodonticsBacterial endotoxin (LPS)Gram-negative bacteriaCalcium hydroxideNew knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion.Faculdade De Odontologia De Bauru - USP2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572004000200002Journal of Applied Oral Science v.12 n.2 2004reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572004000200002info:eu-repo/semantics/openAccessLeonardo,Mario RobertoSilva,Raquel Assed Bezerra daAssed,SadaNelson-Filho,Pauloeng2004-07-27T00:00:00Zoai:scielo:S1678-77572004000200002Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2004-07-27T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Importance of bacterial endotoxin (LPS) in endodontics |
title |
Importance of bacterial endotoxin (LPS) in endodontics |
spellingShingle |
Importance of bacterial endotoxin (LPS) in endodontics Leonardo,Mario Roberto Bacterial endotoxin (LPS) Gram-negative bacteria Calcium hydroxide |
title_short |
Importance of bacterial endotoxin (LPS) in endodontics |
title_full |
Importance of bacterial endotoxin (LPS) in endodontics |
title_fullStr |
Importance of bacterial endotoxin (LPS) in endodontics |
title_full_unstemmed |
Importance of bacterial endotoxin (LPS) in endodontics |
title_sort |
Importance of bacterial endotoxin (LPS) in endodontics |
author |
Leonardo,Mario Roberto |
author_facet |
Leonardo,Mario Roberto Silva,Raquel Assed Bezerra da Assed,Sada Nelson-Filho,Paulo |
author_role |
author |
author2 |
Silva,Raquel Assed Bezerra da Assed,Sada Nelson-Filho,Paulo |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Leonardo,Mario Roberto Silva,Raquel Assed Bezerra da Assed,Sada Nelson-Filho,Paulo |
dc.subject.por.fl_str_mv |
Bacterial endotoxin (LPS) Gram-negative bacteria Calcium hydroxide |
topic |
Bacterial endotoxin (LPS) Gram-negative bacteria Calcium hydroxide |
description |
New knowledge of the structure and biological activity of endotoxins (LPS) has revolutionized concepts concerning their mechanisms of action and forms of inactivation. Since the 1980's, technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, predominate in root canals of teeth with pulp necrosis and radiographically visible chronic periapical lesions. Gram-negative bacteria not only have different factors of virulence and generate sub-products that are toxic to apical and periapical tissues, as also contain endotoxin (LPS) on their cell wall. This is especially important because endotoxin is released during multiplication or bacterial death, causing a series of biological effects that lead to an inflammatory reaction and resorption of mineralized tissues. Thus, due to the role of endotoxin in the pathogenesis of periapical lesions, we reviewed the literature concerning the biological activity of endotoxin and the relevance of its inactivation during treatment of teeth with pulp necrosis and chronic periapical lesion. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572004000200002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572004000200002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-77572004000200002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.12 n.2 2004 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936433484169216 |