Methylparaben concentration in commercial Brazilian local anesthetics solutions

Detalhes bibliográficos
Autor(a) principal: Silva, Gustavo Henrique Rodriguez da
Data de Publicação: 2012
Outros Autores: Bottoli, Carla Beatriz Grespan, Groppo, Francisco Carlos, Volpato, Maria Cristina, Ranali, José, Ramacciato, Juliana Cama, Motta, Rogério Heládio Lopes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/46258
Resumo: OBJECTIVE: To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL AND METHODS: Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1. RESULTS: When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben. CONCLUSION: 1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence.
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spelling Methylparaben concentration in commercial Brazilian local anesthetics solutionsHypersensitivityAllergyLocal anestheticsOBJECTIVE: To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL AND METHODS: Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1. RESULTS: When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben. CONCLUSION: 1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence.Universidade de São Paulo. Faculdade de Odontologia de Bauru2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/4625810.1590/S1678-77572012000400009Journal of Applied Oral Science; Vol. 20 No. 4 (2012); 444-448Journal of Applied Oral Science; Vol. 20 Núm. 4 (2012); 444-448Journal of Applied Oral Science; v. 20 n. 4 (2012); 444-4481678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/46258/49880Copyright (c) 2012 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessSilva, Gustavo Henrique Rodriguez daBottoli, Carla Beatriz GrespanGroppo, Francisco CarlosVolpato, Maria CristinaRanali, JoséRamacciato, Juliana CamaMotta, Rogério Heládio Lopes2012-10-18T19:45:59Zoai:revistas.usp.br:article/46258Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-10-18T19:45:59Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Methylparaben concentration in commercial Brazilian local anesthetics solutions
title Methylparaben concentration in commercial Brazilian local anesthetics solutions
spellingShingle Methylparaben concentration in commercial Brazilian local anesthetics solutions
Silva, Gustavo Henrique Rodriguez da
Hypersensitivity
Allergy
Local anesthetics
title_short Methylparaben concentration in commercial Brazilian local anesthetics solutions
title_full Methylparaben concentration in commercial Brazilian local anesthetics solutions
title_fullStr Methylparaben concentration in commercial Brazilian local anesthetics solutions
title_full_unstemmed Methylparaben concentration in commercial Brazilian local anesthetics solutions
title_sort Methylparaben concentration in commercial Brazilian local anesthetics solutions
author Silva, Gustavo Henrique Rodriguez da
author_facet Silva, Gustavo Henrique Rodriguez da
Bottoli, Carla Beatriz Grespan
Groppo, Francisco Carlos
Volpato, Maria Cristina
Ranali, José
Ramacciato, Juliana Cama
Motta, Rogério Heládio Lopes
author_role author
author2 Bottoli, Carla Beatriz Grespan
Groppo, Francisco Carlos
Volpato, Maria Cristina
Ranali, José
Ramacciato, Juliana Cama
Motta, Rogério Heládio Lopes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Gustavo Henrique Rodriguez da
Bottoli, Carla Beatriz Grespan
Groppo, Francisco Carlos
Volpato, Maria Cristina
Ranali, José
Ramacciato, Juliana Cama
Motta, Rogério Heládio Lopes
dc.subject.por.fl_str_mv Hypersensitivity
Allergy
Local anesthetics
topic Hypersensitivity
Allergy
Local anesthetics
description OBJECTIVE: To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL AND METHODS: Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1. RESULTS: When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben. CONCLUSION: 1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/46258
10.1590/S1678-77572012000400009
url https://www.revistas.usp.br/jaos/article/view/46258
identifier_str_mv 10.1590/S1678-77572012000400009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/46258/49880
dc.rights.driver.fl_str_mv Copyright (c) 2012 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2012 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 20 No. 4 (2012); 444-448
Journal of Applied Oral Science; Vol. 20 Núm. 4 (2012); 444-448
Journal of Applied Oral Science; v. 20 n. 4 (2012); 444-448
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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