Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
DOI: | 10.1590/1678-775720150235 |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/106978 |
Resumo: | The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized. |
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oai:revistas.usp.br:article/106978 |
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USP-17 |
network_name_str |
Journal of applied oral science (Online) |
spelling |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized. Universidade de São Paulo. Faculdade de Odontologia de Bauru2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/10697810.1590/1678-775720150235Journal of Applied Oral Science; Vol. 23 No. 5 (2015); 497-507Journal of Applied Oral Science; Vol. 23 Núm. 5 (2015); 497-507Journal of Applied Oral Science; v. 23 n. 5 (2015); 497-5071678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/106978/105550Copyright (c) 2015 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessPAULA, Anabela BaptistaDIAS, Maria IsabelFERREIRA, Manuel MarquesCARRILHO, TeresaMARTO, Carlos MiguelCASALTA, JoãoCABRITA, António SilvérioCARRILHO, Eunice2015-11-03T11:46:22Zoai:revistas.usp.br:article/106978Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2015-11-03T11:46:22Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
title |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
spellingShingle |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats PAULA, Anabela Baptista PAULA, Anabela Baptista |
title_short |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
title_full |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
title_fullStr |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
title_full_unstemmed |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
title_sort |
Effects on gastric mucosa induced by dental bleaching – an experimental study with 6% hydrogen peroxide in rats |
author |
PAULA, Anabela Baptista |
author_facet |
PAULA, Anabela Baptista PAULA, Anabela Baptista DIAS, Maria Isabel FERREIRA, Manuel Marques CARRILHO, Teresa MARTO, Carlos Miguel CASALTA, João CABRITA, António Silvério CARRILHO, Eunice DIAS, Maria Isabel FERREIRA, Manuel Marques CARRILHO, Teresa MARTO, Carlos Miguel CASALTA, João CABRITA, António Silvério CARRILHO, Eunice |
author_role |
author |
author2 |
DIAS, Maria Isabel FERREIRA, Manuel Marques CARRILHO, Teresa MARTO, Carlos Miguel CASALTA, João CABRITA, António Silvério CARRILHO, Eunice |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
PAULA, Anabela Baptista DIAS, Maria Isabel FERREIRA, Manuel Marques CARRILHO, Teresa MARTO, Carlos Miguel CASALTA, João CABRITA, António Silvério CARRILHO, Eunice |
description |
The value of aesthetic dentistry has precipitated several developments in the investigation of dental materials related to this field. The free marketing of these products is a problem and it is subject to various interpretations regarding its legality. There are several techniques for tooth whitening, the most used one being the external bleaching. It is the later version of such technique that poses the greatest danger of ingesting the product. The present study analysed the systemic effect of these products when they are swallowed.Objective This experimental study aimed to observe the effects of a tooth whitening product, whose active agent is 6% hydrogen peroxide, on the gastric mucosa of healthy and non-tumour gastric pathology animals.Material and Methods Fifty Wistar-Han rats were used and then distributed into 5 groups, one for control and four test groups in which the bleaching product was administered in animals with and without non-tumour gastric pathology (induced by the administration of 1 sample of 50% ethanol and 5% of drinking water during 6 days) at different times of study by gavage. There was a decrease in body weight in animals of groups handled during the study period, which was most pronounced in IV and VA groups. Changes in spleen weight relative to body weight revealed no statistically significant changes. An analysis of the frequency was performed on the results of macroscopic observation of the gastric mucosa.Results The gastric mucosa revealed lesions in all manipulated groups, being more frequent in groups III and IV. It appears that there is a synergism when using hydrogen peroxide and 50% ethanol in the same group.Conclusion Therefore, it seems that there are some signs of toxicity 3 to 4 days after administration of 6% hydrogen peroxide. The prescription of these therapies must be controlled by the clinician and the risks must be minimized. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/106978 10.1590/1678-775720150235 |
url |
https://www.revistas.usp.br/jaos/article/view/106978 |
identifier_str_mv |
10.1590/1678-775720150235 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/106978/105550 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2015 Journal of Applied Oral Science info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2015 Journal of Applied Oral Science |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 23 No. 5 (2015); 497-507 Journal of Applied Oral Science; Vol. 23 Núm. 5 (2015); 497-507 Journal of Applied Oral Science; v. 23 n. 5 (2015); 497-507 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
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1822181690680803328 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1678-775720150235 |