Reduction of postsurgical adhesions in a rat model: a comparative study

Detalhes bibliográficos
Autor(a) principal: Irkorucu, Oktay
Data de Publicação: 2009
Outros Autores: Ferahköşe, Zafer, Memiş, Leyla, Ekinci, Özgür, Akın, Murat
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17982
Resumo: BACKGROUND: Adhesion formation after peritoneal surgery is a major cause of postoperative bowel obstruction, infertility, and chronic pelvic pain. In this study, we compared the possible individual effects of phosphatidylcholine (PC), Seprafilm® II, and tissue plasminogen activator (t-PA) and the combined effects of phosphatidylcholine and t-PA on postoperative adhesion formation in a rat surgical model. MATERIALS AND METHODS: A total of 50 Wistar male rats underwent median laparotomy and standardized abrasion of the visceral and parietal peritoneum. phosphatidylcholine, Seprafilm II, and t-PA alone and phosphatidylcholine and t-PA in combination were applied intraperitoneally at the end of the surgical procedure. Seven days after surgery, a relaparotomy was performed for adhesion grading and histopathological examination. RESULTS: A comparison of adhesion stages demonstrated a significant difference between the control group and the study groups (p
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spelling Reduction of postsurgical adhesions in a rat model: a comparative study Intraabdominal adhesionPhosphatidylcholineTissue plasminogen activatorSeprafilm BACKGROUND: Adhesion formation after peritoneal surgery is a major cause of postoperative bowel obstruction, infertility, and chronic pelvic pain. In this study, we compared the possible individual effects of phosphatidylcholine (PC), Seprafilm® II, and tissue plasminogen activator (t-PA) and the combined effects of phosphatidylcholine and t-PA on postoperative adhesion formation in a rat surgical model. MATERIALS AND METHODS: A total of 50 Wistar male rats underwent median laparotomy and standardized abrasion of the visceral and parietal peritoneum. phosphatidylcholine, Seprafilm II, and t-PA alone and phosphatidylcholine and t-PA in combination were applied intraperitoneally at the end of the surgical procedure. Seven days after surgery, a relaparotomy was performed for adhesion grading and histopathological examination. RESULTS: A comparison of adhesion stages demonstrated a significant difference between the control group and the study groups (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1798210.1590/S1807-59322009000200012Clinics; Vol. 64 No. 2 (2009); 143-148 Clinics; v. 64 n. 2 (2009); 143-148 Clinics; Vol. 64 Núm. 2 (2009); 143-148 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17982/20047Irkorucu, OktayFerahköşe, ZaferMemiş, LeylaEkinci, ÖzgürAkın, Muratinfo:eu-repo/semantics/openAccess2012-05-22T18:49:44Zoai:revistas.usp.br:article/17982Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:49:44Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Reduction of postsurgical adhesions in a rat model: a comparative study
title Reduction of postsurgical adhesions in a rat model: a comparative study
spellingShingle Reduction of postsurgical adhesions in a rat model: a comparative study
Irkorucu, Oktay
Intraabdominal adhesion
Phosphatidylcholine
Tissue plasminogen activator
Seprafilm
title_short Reduction of postsurgical adhesions in a rat model: a comparative study
title_full Reduction of postsurgical adhesions in a rat model: a comparative study
title_fullStr Reduction of postsurgical adhesions in a rat model: a comparative study
title_full_unstemmed Reduction of postsurgical adhesions in a rat model: a comparative study
title_sort Reduction of postsurgical adhesions in a rat model: a comparative study
author Irkorucu, Oktay
author_facet Irkorucu, Oktay
Ferahköşe, Zafer
Memiş, Leyla
Ekinci, Özgür
Akın, Murat
author_role author
author2 Ferahköşe, Zafer
Memiş, Leyla
Ekinci, Özgür
Akın, Murat
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Irkorucu, Oktay
Ferahköşe, Zafer
Memiş, Leyla
Ekinci, Özgür
Akın, Murat
dc.subject.por.fl_str_mv Intraabdominal adhesion
Phosphatidylcholine
Tissue plasminogen activator
Seprafilm
topic Intraabdominal adhesion
Phosphatidylcholine
Tissue plasminogen activator
Seprafilm
description BACKGROUND: Adhesion formation after peritoneal surgery is a major cause of postoperative bowel obstruction, infertility, and chronic pelvic pain. In this study, we compared the possible individual effects of phosphatidylcholine (PC), Seprafilm® II, and tissue plasminogen activator (t-PA) and the combined effects of phosphatidylcholine and t-PA on postoperative adhesion formation in a rat surgical model. MATERIALS AND METHODS: A total of 50 Wistar male rats underwent median laparotomy and standardized abrasion of the visceral and parietal peritoneum. phosphatidylcholine, Seprafilm II, and t-PA alone and phosphatidylcholine and t-PA in combination were applied intraperitoneally at the end of the surgical procedure. Seven days after surgery, a relaparotomy was performed for adhesion grading and histopathological examination. RESULTS: A comparison of adhesion stages demonstrated a significant difference between the control group and the study groups (p
publishDate 2009
dc.date.none.fl_str_mv 2009-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17982
10.1590/S1807-59322009000200012
url https://www.revistas.usp.br/clinics/article/view/17982
identifier_str_mv 10.1590/S1807-59322009000200012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17982/20047
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 64 No. 2 (2009); 143-148
Clinics; v. 64 n. 2 (2009); 143-148
Clinics; Vol. 64 Núm. 2 (2009); 143-148
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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