Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18399 |
Resumo: | OBJECTIVE: The aim of this prospective, randomized study was to evaluate the hemodynamic and analgesic effects of ketamine by comparing it with propofol starting at the induction of anesthesia until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery. INTRODUCTION: Anesthetic induction and maintenance may induce myocardial ischemia in patients with coronary artery disease. A primary goal in the anesthesia of patients undergoing coronary artery bypass grafting surgery is both the attenuation of sympathetic responses to noxious stimuli and the prevention of hypotension. METHODS: Thirty patients undergoing coronary artery bypass grafting surgery were randomized to receive either ketamine 2 mg.kg-1 (Group K) or propofol 0.5 mg.kg-1 (Group P) during induction of anesthesia. Patients also received standardized doses of midazolam, fentanyl, and rocuronium in the induction sequence. The duration of anesthesia from induction to skin incision and sternotomy, as well as the supplemental doses of fentanyl and sevoflurane, were recorded. Heart rate, mean arterial pressure, central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index, systemic and pulmonary vascular resistance indices, stroke work index, and left and right ventricular stroke work indices were obtained before induction of anesthesia; one minute after induction; one, three, five, and ten minutes after intubation; one minute after skin incision; and at one minute after sternotomy. RESULTS: There were significant changes in the measured and calculated hemodynamic variables when compared to their values before induction. One minute after induction, mean arterial pressure and the systemic vascular resistance index decreased significantly in group P (p |
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Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine Coronary artery bypass graftingKetaminePropofolFentanylMidazolam OBJECTIVE: The aim of this prospective, randomized study was to evaluate the hemodynamic and analgesic effects of ketamine by comparing it with propofol starting at the induction of anesthesia until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery. INTRODUCTION: Anesthetic induction and maintenance may induce myocardial ischemia in patients with coronary artery disease. A primary goal in the anesthesia of patients undergoing coronary artery bypass grafting surgery is both the attenuation of sympathetic responses to noxious stimuli and the prevention of hypotension. METHODS: Thirty patients undergoing coronary artery bypass grafting surgery were randomized to receive either ketamine 2 mg.kg-1 (Group K) or propofol 0.5 mg.kg-1 (Group P) during induction of anesthesia. Patients also received standardized doses of midazolam, fentanyl, and rocuronium in the induction sequence. The duration of anesthesia from induction to skin incision and sternotomy, as well as the supplemental doses of fentanyl and sevoflurane, were recorded. Heart rate, mean arterial pressure, central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index, systemic and pulmonary vascular resistance indices, stroke work index, and left and right ventricular stroke work indices were obtained before induction of anesthesia; one minute after induction; one, three, five, and ten minutes after intubation; one minute after skin incision; and at one minute after sternotomy. RESULTS: There were significant changes in the measured and calculated hemodynamic variables when compared to their values before induction. One minute after induction, mean arterial pressure and the systemic vascular resistance index decreased significantly in group P (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1839910.1590/S1807-59322010000200003Clinics; Vol. 65 No. 2 (2010); 133-138 Clinics; v. 65 n. 2 (2010); 133-138 Clinics; Vol. 65 Núm. 2 (2010); 133-138 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18399/20462Basagan-Mogo, ElifGoren, SunaKorfali, GulsenTurker, GurkanKaya, Fatma Nurinfo:eu-repo/semantics/openAccess2012-05-23T11:20:13Zoai:revistas.usp.br:article/18399Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:20:13Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
title |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
spellingShingle |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine Basagan-Mogo, Elif Coronary artery bypass grafting Ketamine Propofol Fentanyl Midazolam |
title_short |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
title_full |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
title_fullStr |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
title_full_unstemmed |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
title_sort |
Induction of anesthesia in coronary artery bypass graft surgery: the hemodynamic and analgesic effects of ketamine |
author |
Basagan-Mogo, Elif |
author_facet |
Basagan-Mogo, Elif Goren, Suna Korfali, Gulsen Turker, Gurkan Kaya, Fatma Nur |
author_role |
author |
author2 |
Goren, Suna Korfali, Gulsen Turker, Gurkan Kaya, Fatma Nur |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Basagan-Mogo, Elif Goren, Suna Korfali, Gulsen Turker, Gurkan Kaya, Fatma Nur |
dc.subject.por.fl_str_mv |
Coronary artery bypass grafting Ketamine Propofol Fentanyl Midazolam |
topic |
Coronary artery bypass grafting Ketamine Propofol Fentanyl Midazolam |
description |
OBJECTIVE: The aim of this prospective, randomized study was to evaluate the hemodynamic and analgesic effects of ketamine by comparing it with propofol starting at the induction of anesthesia until the end of sternotomy in patients undergoing coronary artery bypass grafting surgery. INTRODUCTION: Anesthetic induction and maintenance may induce myocardial ischemia in patients with coronary artery disease. A primary goal in the anesthesia of patients undergoing coronary artery bypass grafting surgery is both the attenuation of sympathetic responses to noxious stimuli and the prevention of hypotension. METHODS: Thirty patients undergoing coronary artery bypass grafting surgery were randomized to receive either ketamine 2 mg.kg-1 (Group K) or propofol 0.5 mg.kg-1 (Group P) during induction of anesthesia. Patients also received standardized doses of midazolam, fentanyl, and rocuronium in the induction sequence. The duration of anesthesia from induction to skin incision and sternotomy, as well as the supplemental doses of fentanyl and sevoflurane, were recorded. Heart rate, mean arterial pressure, central venous pressure, pulmonary arterial pressure, pulmonary capillary wedge pressure, cardiac index, systemic and pulmonary vascular resistance indices, stroke work index, and left and right ventricular stroke work indices were obtained before induction of anesthesia; one minute after induction; one, three, five, and ten minutes after intubation; one minute after skin incision; and at one minute after sternotomy. RESULTS: There were significant changes in the measured and calculated hemodynamic variables when compared to their values before induction. One minute after induction, mean arterial pressure and the systemic vascular resistance index decreased significantly in group P (p |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18399 10.1590/S1807-59322010000200003 |
url |
https://www.revistas.usp.br/clinics/article/view/18399 |
identifier_str_mv |
10.1590/S1807-59322010000200003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18399/20462 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 2 (2010); 133-138 Clinics; v. 65 n. 2 (2010); 133-138 Clinics; Vol. 65 Núm. 2 (2010); 133-138 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222755266756608 |