Novel insights into the genetic and epigenetic paternal contribution to the human embryo

Detalhes bibliográficos
Autor(a) principal: Kumar, Manoj
Data de Publicação: 2013
Outros Autores: Kumar, Kishlay, Jain, Shalu, Hassan, Tarannum, Dada, Rima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/53173
Resumo: The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring.
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spelling Novel insights into the genetic and epigenetic paternal contribution to the human embryo Messenger RNA (mRNA)DNA damageepigenomeDNA integritytelomere The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/5317310.6061/clinics/2013(Sup01)02Clinics; Vol. 68 No. spe (2013); 05-14Clinics; v. 68 n. spe (2013); 05-14Clinics; Vol. 68 Núm. spe (2013); 05-141980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/53173/57234Kumar, ManojKumar, KishlayJain, ShaluHassan, TarannumDada, Rimainfo:eu-repo/semantics/openAccess2013-04-08T20:47:20Zoai:revistas.usp.br:article/53173Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2013-04-08T20:47:20Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Novel insights into the genetic and epigenetic paternal contribution to the human embryo
title Novel insights into the genetic and epigenetic paternal contribution to the human embryo
spellingShingle Novel insights into the genetic and epigenetic paternal contribution to the human embryo
Kumar, Manoj
Messenger RNA (mRNA)
DNA damage
epigenome
DNA integrity
telomere
title_short Novel insights into the genetic and epigenetic paternal contribution to the human embryo
title_full Novel insights into the genetic and epigenetic paternal contribution to the human embryo
title_fullStr Novel insights into the genetic and epigenetic paternal contribution to the human embryo
title_full_unstemmed Novel insights into the genetic and epigenetic paternal contribution to the human embryo
title_sort Novel insights into the genetic and epigenetic paternal contribution to the human embryo
author Kumar, Manoj
author_facet Kumar, Manoj
Kumar, Kishlay
Jain, Shalu
Hassan, Tarannum
Dada, Rima
author_role author
author2 Kumar, Kishlay
Jain, Shalu
Hassan, Tarannum
Dada, Rima
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Kumar, Manoj
Kumar, Kishlay
Jain, Shalu
Hassan, Tarannum
Dada, Rima
dc.subject.por.fl_str_mv Messenger RNA (mRNA)
DNA damage
epigenome
DNA integrity
telomere
topic Messenger RNA (mRNA)
DNA damage
epigenome
DNA integrity
telomere
description The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/53173
10.6061/clinics/2013(Sup01)02
url https://www.revistas.usp.br/clinics/article/view/53173
identifier_str_mv 10.6061/clinics/2013(Sup01)02
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/53173/57234
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 68 No. spe (2013); 05-14
Clinics; v. 68 n. spe (2013); 05-14
Clinics; Vol. 68 Núm. spe (2013); 05-14
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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