Novel insights into the genetic and epigenetic paternal contribution to the human embryo
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/53173 |
Resumo: | The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring. |
id |
USP-19_d88236fd9339a3891fe743f21f58b7b5 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/53173 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo Messenger RNA (mRNA)DNA damageepigenomeDNA integritytelomere The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/5317310.6061/clinics/2013(Sup01)02Clinics; Vol. 68 No. spe (2013); 05-14Clinics; v. 68 n. spe (2013); 05-14Clinics; Vol. 68 Núm. spe (2013); 05-141980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/53173/57234Kumar, ManojKumar, KishlayJain, ShaluHassan, TarannumDada, Rimainfo:eu-repo/semantics/openAccess2013-04-08T20:47:20Zoai:revistas.usp.br:article/53173Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2013-04-08T20:47:20Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
title |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
spellingShingle |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo Kumar, Manoj Messenger RNA (mRNA) DNA damage epigenome DNA integrity telomere |
title_short |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
title_full |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
title_fullStr |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
title_full_unstemmed |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
title_sort |
Novel insights into the genetic and epigenetic paternal contribution to the human embryo |
author |
Kumar, Manoj |
author_facet |
Kumar, Manoj Kumar, Kishlay Jain, Shalu Hassan, Tarannum Dada, Rima |
author_role |
author |
author2 |
Kumar, Kishlay Jain, Shalu Hassan, Tarannum Dada, Rima |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Kumar, Manoj Kumar, Kishlay Jain, Shalu Hassan, Tarannum Dada, Rima |
dc.subject.por.fl_str_mv |
Messenger RNA (mRNA) DNA damage epigenome DNA integrity telomere |
topic |
Messenger RNA (mRNA) DNA damage epigenome DNA integrity telomere |
description |
The integrity of the sperm genome and epigenome are critical for normal embryonic development. The advent of assisted reproductive technology has led to an increased understanding of the role of sperm in fertilization and embryogenesis. During fertilization, the sperm transmits not only nuclear DNA to the oocyte but also activation factor, centrosomes, and a host of messenger RNA and microRNAs. This complex complement of microRNAs and other non-coding RNAs is believed to modify important post-fertilization events. Thus, the health of the sperm genome and epigenome is critical for improving assisted conception rates and the birth of healthy offspring. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/53173 10.6061/clinics/2013(Sup01)02 |
url |
https://www.revistas.usp.br/clinics/article/view/53173 |
identifier_str_mv |
10.6061/clinics/2013(Sup01)02 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/53173/57234 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 68 No. spe (2013); 05-14 Clinics; v. 68 n. spe (2013); 05-14 Clinics; Vol. 68 Núm. spe (2013); 05-14 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222759753613313 |