Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth

Detalhes bibliográficos
Autor(a) principal: Hosseini, Mahmoud
Data de Publicação: 2010
Outros Autores: Dastghaib, Samaneh Sadat, Rafatpanah, Houshang, Hadjzadeh, Mosa Al-Reza, Nahrevanian, Hossein, Farrokhi, Ismaeil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18501
Resumo: INTRODUCTION: Severe cognitive impairment follows thyroid hormone deficiency during the neonatal period. The role of nitric oxide (NO) in learning and memory has been widely investigated. METHODS: This study aimed to investigate the effect of hypothyroidism during neonatal and juvenile periods on NO metabolites in the hippocampi of rats and on learning and memory. Animals were divided into two groups and treated for 60 days from the first day of lactation. The control group received regular water, whereas animals in a separate group were given water supplemented with 0.03% methimazole to induce hypothyroidism. Male offspring were selected and tested in the Morris water maze. Samples of blood were collected to measure the metabolites of NO, NO2, NO3 and thyroxine. The animals were then sacrificed, and their hippocampi were removed to measure the tissue concentrations of NO2 and NO3. DISCUSSION: Compared to the control group's offspring, serum thyroxine levels in the methimazole group's offspring were significantly lower (P
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spelling Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth HypothyroidismLearningMemoryNitric OxideOffspring INTRODUCTION: Severe cognitive impairment follows thyroid hormone deficiency during the neonatal period. The role of nitric oxide (NO) in learning and memory has been widely investigated. METHODS: This study aimed to investigate the effect of hypothyroidism during neonatal and juvenile periods on NO metabolites in the hippocampi of rats and on learning and memory. Animals were divided into two groups and treated for 60 days from the first day of lactation. The control group received regular water, whereas animals in a separate group were given water supplemented with 0.03% methimazole to induce hypothyroidism. Male offspring were selected and tested in the Morris water maze. Samples of blood were collected to measure the metabolites of NO, NO2, NO3 and thyroxine. The animals were then sacrificed, and their hippocampi were removed to measure the tissue concentrations of NO2 and NO3. DISCUSSION: Compared to the control group's offspring, serum thyroxine levels in the methimazole group's offspring were significantly lower (PHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1850110.1590/S1807-59322010001100021Clinics; Vol. 65 No. 11 (2010); 1175-1181 Clinics; v. 65 n. 11 (2010); 1175-1181 Clinics; Vol. 65 Núm. 11 (2010); 1175-1181 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18501/20564Hosseini, MahmoudDastghaib, Samaneh SadatRafatpanah, HoushangHadjzadeh, Mosa Al-RezaNahrevanian, HosseinFarrokhi, Ismaeilinfo:eu-repo/semantics/openAccess2012-05-23T11:27:51Zoai:revistas.usp.br:article/18501Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:27:51Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
title Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
spellingShingle Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
Hosseini, Mahmoud
Hypothyroidism
Learning
Memory
Nitric Oxide
Offspring
title_short Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
title_full Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
title_fullStr Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
title_full_unstemmed Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
title_sort Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth
author Hosseini, Mahmoud
author_facet Hosseini, Mahmoud
Dastghaib, Samaneh Sadat
Rafatpanah, Houshang
Hadjzadeh, Mosa Al-Reza
Nahrevanian, Hossein
Farrokhi, Ismaeil
author_role author
author2 Dastghaib, Samaneh Sadat
Rafatpanah, Houshang
Hadjzadeh, Mosa Al-Reza
Nahrevanian, Hossein
Farrokhi, Ismaeil
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Hosseini, Mahmoud
Dastghaib, Samaneh Sadat
Rafatpanah, Houshang
Hadjzadeh, Mosa Al-Reza
Nahrevanian, Hossein
Farrokhi, Ismaeil
dc.subject.por.fl_str_mv Hypothyroidism
Learning
Memory
Nitric Oxide
Offspring
topic Hypothyroidism
Learning
Memory
Nitric Oxide
Offspring
description INTRODUCTION: Severe cognitive impairment follows thyroid hormone deficiency during the neonatal period. The role of nitric oxide (NO) in learning and memory has been widely investigated. METHODS: This study aimed to investigate the effect of hypothyroidism during neonatal and juvenile periods on NO metabolites in the hippocampi of rats and on learning and memory. Animals were divided into two groups and treated for 60 days from the first day of lactation. The control group received regular water, whereas animals in a separate group were given water supplemented with 0.03% methimazole to induce hypothyroidism. Male offspring were selected and tested in the Morris water maze. Samples of blood were collected to measure the metabolites of NO, NO2, NO3 and thyroxine. The animals were then sacrificed, and their hippocampi were removed to measure the tissue concentrations of NO2 and NO3. DISCUSSION: Compared to the control group's offspring, serum thyroxine levels in the methimazole group's offspring were significantly lower (P
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18501
10.1590/S1807-59322010001100021
url https://www.revistas.usp.br/clinics/article/view/18501
identifier_str_mv 10.1590/S1807-59322010001100021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18501/20564
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 65 No. 11 (2010); 1175-1181
Clinics; v. 65 n. 11 (2010); 1175-1181
Clinics; Vol. 65 Núm. 11 (2010); 1175-1181
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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