Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil

Detalhes bibliográficos
Autor(a) principal: Guimarães, Mark Drew Crosland
Data de Publicação: 2008
Outros Autores: Rocha, Gustavo Machado, Campos, Lorenza Nogueira, Freitas, Felipe Melo Teixeira de, Gualberto, Felipe Augusto Souza, Teixeira, Ramiro d’Ávila Rivelli, Castilho, Fábio Morato de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17847
Resumo: OBJECTIVE: To describe the degree of difficulty that HIV-infected patients have with therapy treatment. INTRODUCTION: Patients’ perceptions about their treatment are a determinant factor for improved adherence and a better quality of life. METHODS: Two cross-sectional analyses were conducted in public AIDS referral centers in Brazil among patients initiating treatment. Patients interviewed at baseline, after one month, and after seven months following the beginning of treatment were asked to classify and justify the degree of difficulty with treatment. Logistic regression was used for analysis. RESULTS: Among 406 patients initiating treatment, 350 (86.2%) and 209 (51.5%) returned for their first and third visits, respectively. Treatment perceptions ranged from medium to very difficult for 51.4% and 37.3% on the first and third visits, respectively. The main difficulties reported were adverse reactions to the medication and scheduling. A separate logistic regression indicated that the HIV-seropositive status disclosure, symptoms of anxiety, absence of psychotherapy, higher CD4+ cell count (>; 200/mm³) and high (>; 4) adverse reaction count reported were independently associated with the degree of difficulty in the first visit, while CDC clinical category A, pill burden (>; 7 pills), use of other medications, high (>; 4) adverse reaction count reported and low understanding of medical orientation showed independent association for the third visit. CONCLUSIONS: A significant level of difficulty was observed with treatment. Our analyses suggest the need for early assessment of difficulties with treatment, highlighting the importance of modifiable factors that may contribute to better adherence to the treatment protocol.
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spelling Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil AIDSTreatmentPatient PerceptionAdherenceModifiable Factors OBJECTIVE: To describe the degree of difficulty that HIV-infected patients have with therapy treatment. INTRODUCTION: Patients’ perceptions about their treatment are a determinant factor for improved adherence and a better quality of life. METHODS: Two cross-sectional analyses were conducted in public AIDS referral centers in Brazil among patients initiating treatment. Patients interviewed at baseline, after one month, and after seven months following the beginning of treatment were asked to classify and justify the degree of difficulty with treatment. Logistic regression was used for analysis. RESULTS: Among 406 patients initiating treatment, 350 (86.2%) and 209 (51.5%) returned for their first and third visits, respectively. Treatment perceptions ranged from medium to very difficult for 51.4% and 37.3% on the first and third visits, respectively. The main difficulties reported were adverse reactions to the medication and scheduling. A separate logistic regression indicated that the HIV-seropositive status disclosure, symptoms of anxiety, absence of psychotherapy, higher CD4+ cell count (>; 200/mm³) and high (>; 4) adverse reaction count reported were independently associated with the degree of difficulty in the first visit, while CDC clinical category A, pill burden (>; 7 pills), use of other medications, high (>; 4) adverse reaction count reported and low understanding of medical orientation showed independent association for the third visit. CONCLUSIONS: A significant level of difficulty was observed with treatment. Our analyses suggest the need for early assessment of difficulties with treatment, highlighting the importance of modifiable factors that may contribute to better adherence to the treatment protocol. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1784710.1590/S1807-59322008000200003Clinics; Vol. 63 No. 2 (2008); 165-172 Clinics; v. 63 n. 2 (2008); 165-172 Clinics; Vol. 63 Núm. 2 (2008); 165-172 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17847/19912Guimarães, Mark Drew CroslandRocha, Gustavo MachadoCampos, Lorenza NogueiraFreitas, Felipe Melo Teixeira deGualberto, Felipe Augusto SouzaTeixeira, Ramiro d’Ávila RivelliCastilho, Fábio Morato deinfo:eu-repo/semantics/openAccess2012-05-22T18:37:44Zoai:revistas.usp.br:article/17847Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:37:44Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
title Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
spellingShingle Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
Guimarães, Mark Drew Crosland
AIDS
Treatment
Patient Perception
Adherence
Modifiable Factors
title_short Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
title_full Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
title_fullStr Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
title_full_unstemmed Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
title_sort Difficulties reported by hiv-infected patients using antiretroviral therapy in brazil
author Guimarães, Mark Drew Crosland
author_facet Guimarães, Mark Drew Crosland
Rocha, Gustavo Machado
Campos, Lorenza Nogueira
Freitas, Felipe Melo Teixeira de
Gualberto, Felipe Augusto Souza
Teixeira, Ramiro d’Ávila Rivelli
Castilho, Fábio Morato de
author_role author
author2 Rocha, Gustavo Machado
Campos, Lorenza Nogueira
Freitas, Felipe Melo Teixeira de
Gualberto, Felipe Augusto Souza
Teixeira, Ramiro d’Ávila Rivelli
Castilho, Fábio Morato de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Mark Drew Crosland
Rocha, Gustavo Machado
Campos, Lorenza Nogueira
Freitas, Felipe Melo Teixeira de
Gualberto, Felipe Augusto Souza
Teixeira, Ramiro d’Ávila Rivelli
Castilho, Fábio Morato de
dc.subject.por.fl_str_mv AIDS
Treatment
Patient Perception
Adherence
Modifiable Factors
topic AIDS
Treatment
Patient Perception
Adherence
Modifiable Factors
description OBJECTIVE: To describe the degree of difficulty that HIV-infected patients have with therapy treatment. INTRODUCTION: Patients’ perceptions about their treatment are a determinant factor for improved adherence and a better quality of life. METHODS: Two cross-sectional analyses were conducted in public AIDS referral centers in Brazil among patients initiating treatment. Patients interviewed at baseline, after one month, and after seven months following the beginning of treatment were asked to classify and justify the degree of difficulty with treatment. Logistic regression was used for analysis. RESULTS: Among 406 patients initiating treatment, 350 (86.2%) and 209 (51.5%) returned for their first and third visits, respectively. Treatment perceptions ranged from medium to very difficult for 51.4% and 37.3% on the first and third visits, respectively. The main difficulties reported were adverse reactions to the medication and scheduling. A separate logistic regression indicated that the HIV-seropositive status disclosure, symptoms of anxiety, absence of psychotherapy, higher CD4+ cell count (>; 200/mm³) and high (>; 4) adverse reaction count reported were independently associated with the degree of difficulty in the first visit, while CDC clinical category A, pill burden (>; 7 pills), use of other medications, high (>; 4) adverse reaction count reported and low understanding of medical orientation showed independent association for the third visit. CONCLUSIONS: A significant level of difficulty was observed with treatment. Our analyses suggest the need for early assessment of difficulties with treatment, highlighting the importance of modifiable factors that may contribute to better adherence to the treatment protocol.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17847
10.1590/S1807-59322008000200003
url https://www.revistas.usp.br/clinics/article/view/17847
identifier_str_mv 10.1590/S1807-59322008000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17847/19912
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 63 No. 2 (2008); 165-172
Clinics; v. 63 n. 2 (2008); 165-172
Clinics; Vol. 63 Núm. 2 (2008); 165-172
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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