Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19566 |
Resumo: | INTRODUCTION: Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES: To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS: A total of 24 female Sprague-Dawley rats (200-250 g) were randomly divided into 4 groups: (i) the sham-operated group; (ii) the ovariectomized-control group; (iii) the ovariectomized + estrogen-replacement therapy (ovariectomized-control + estrogen replacement therapy) group, which was supplemented with estrogen (100 μg/kg/day); and (iv) the ovariectomized + Piper sarmentosum (ovariectomized + Piper sarmentosum) group, which was supplemented with a water-based Piper sarmentosum extract (125 mg/kg). Six weeks after an ovariectomy, the right femora were fractured at the mid-diaphysis, and a K-wire was inserted. Each group of rats received their respective treatment for 6 weeks. Following sacrifice, the right femora were subjected to radiological assessment. RESULTS: The mean axial callus volume was significantly higher in the ovariectomized-control group (68.2 + 11.74 mm³) than in the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups (20.4 + 4.05, 22.4 + 4.14 and 17.5 + 3.68 mm³, respectively). The median callus scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups had median (range, minimum - maximum value) as 1.0 (0 - 2), 1.0 (1 - 2) and 1.0 (1 - 2), respectively, which were significantly lower than the ovariectomized-control group score of 2.0 (2 - 3). The median fracture scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups were 3.0 (3 - 4), 3.0 (2 - 3) and 3.0 (2 - 3), respectively, which were significantly higher than the ovariectomized-control group score of 2.0 (1 - 2) (p |
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Clinics |
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Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study Piper sarmentosumAntioxidantFractureHealingOsteoporosisOvariectomy INTRODUCTION: Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES: To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS: A total of 24 female Sprague-Dawley rats (200-250 g) were randomly divided into 4 groups: (i) the sham-operated group; (ii) the ovariectomized-control group; (iii) the ovariectomized + estrogen-replacement therapy (ovariectomized-control + estrogen replacement therapy) group, which was supplemented with estrogen (100 μg/kg/day); and (iv) the ovariectomized + Piper sarmentosum (ovariectomized + Piper sarmentosum) group, which was supplemented with a water-based Piper sarmentosum extract (125 mg/kg). Six weeks after an ovariectomy, the right femora were fractured at the mid-diaphysis, and a K-wire was inserted. Each group of rats received their respective treatment for 6 weeks. Following sacrifice, the right femora were subjected to radiological assessment. RESULTS: The mean axial callus volume was significantly higher in the ovariectomized-control group (68.2 + 11.74 mm³) than in the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups (20.4 + 4.05, 22.4 + 4.14 and 17.5 + 3.68 mm³, respectively). The median callus scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups had median (range, minimum - maximum value) as 1.0 (0 - 2), 1.0 (1 - 2) and 1.0 (1 - 2), respectively, which were significantly lower than the ovariectomized-control group score of 2.0 (2 - 3). The median fracture scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups were 3.0 (3 - 4), 3.0 (2 - 3) and 3.0 (2 - 3), respectively, which were significantly higher than the ovariectomized-control group score of 2.0 (1 - 2) (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1956610.1590/S1807-59322011000500025Clinics; Vol. 66 No. 5 (2011); 865-872 Clinics; v. 66 n. 5 (2011); 865-872 Clinics; Vol. 66 Núm. 5 (2011); 865-872 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19566/21629Estai, Mohamed AbdallaSuhaimi, Farihah HajiDas, SrijitFadzilah, Fazalina MohdAlhabshi, Sharifah Majedah IdrusShuid, Ahmad NazrunSoelaiman, Ima-Nirwanainfo:eu-repo/semantics/openAccess2012-05-23T16:49:04Zoai:revistas.usp.br:article/19566Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:49:04Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
title |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
spellingShingle |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study Estai, Mohamed Abdalla Piper sarmentosum Antioxidant Fracture Healing Osteoporosis Ovariectomy |
title_short |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
title_full |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
title_fullStr |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
title_full_unstemmed |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
title_sort |
Piper sarmentosum enhances fracture healing in ovariectomized osteoporotic rats: a radiological study |
author |
Estai, Mohamed Abdalla |
author_facet |
Estai, Mohamed Abdalla Suhaimi, Farihah Haji Das, Srijit Fadzilah, Fazalina Mohd Alhabshi, Sharifah Majedah Idrus Shuid, Ahmad Nazrun Soelaiman, Ima-Nirwana |
author_role |
author |
author2 |
Suhaimi, Farihah Haji Das, Srijit Fadzilah, Fazalina Mohd Alhabshi, Sharifah Majedah Idrus Shuid, Ahmad Nazrun Soelaiman, Ima-Nirwana |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Estai, Mohamed Abdalla Suhaimi, Farihah Haji Das, Srijit Fadzilah, Fazalina Mohd Alhabshi, Sharifah Majedah Idrus Shuid, Ahmad Nazrun Soelaiman, Ima-Nirwana |
dc.subject.por.fl_str_mv |
Piper sarmentosum Antioxidant Fracture Healing Osteoporosis Ovariectomy |
topic |
Piper sarmentosum Antioxidant Fracture Healing Osteoporosis Ovariectomy |
description |
INTRODUCTION: Osteoporotic fractures are common during osteoporotic states. Piper sarmentosum extract is known to possess antioxidant and anti-inflammatory properties. OBJECTIVES: To observe the radiological changes in fracture calluses following administration of a Piper sarmentosum extract during an estrogen-deficient state. METHODS: A total of 24 female Sprague-Dawley rats (200-250 g) were randomly divided into 4 groups: (i) the sham-operated group; (ii) the ovariectomized-control group; (iii) the ovariectomized + estrogen-replacement therapy (ovariectomized-control + estrogen replacement therapy) group, which was supplemented with estrogen (100 μg/kg/day); and (iv) the ovariectomized + Piper sarmentosum (ovariectomized + Piper sarmentosum) group, which was supplemented with a water-based Piper sarmentosum extract (125 mg/kg). Six weeks after an ovariectomy, the right femora were fractured at the mid-diaphysis, and a K-wire was inserted. Each group of rats received their respective treatment for 6 weeks. Following sacrifice, the right femora were subjected to radiological assessment. RESULTS: The mean axial callus volume was significantly higher in the ovariectomized-control group (68.2 + 11.74 mm³) than in the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups (20.4 + 4.05, 22.4 + 4.14 and 17.5 + 3.68 mm³, respectively). The median callus scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups had median (range, minimum - maximum value) as 1.0 (0 - 2), 1.0 (1 - 2) and 1.0 (1 - 2), respectively, which were significantly lower than the ovariectomized-control group score of 2.0 (2 - 3). The median fracture scores for the sham-operated, estrogen-replacement-therapy and Piper sarmentosum groups were 3.0 (3 - 4), 3.0 (2 - 3) and 3.0 (2 - 3), respectively, which were significantly higher than the ovariectomized-control group score of 2.0 (1 - 2) (p |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19566 10.1590/S1807-59322011000500025 |
url |
https://www.revistas.usp.br/clinics/article/view/19566 |
identifier_str_mv |
10.1590/S1807-59322011000500025 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19566/21629 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 5 (2011); 865-872 Clinics; v. 66 n. 5 (2011); 865-872 Clinics; Vol. 66 Núm. 5 (2011); 865-872 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222757791727616 |