Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100306 |
Resumo: | ABSTRACT OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon. |
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Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in MaranhãoSeroepidemiologic StudiesCoronavirus InfectionsImmunity, HerdMortalityABSTRACT OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon.Faculdade de Saúde Pública da Universidade de São Paulo2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100306Revista de Saúde Pública v.54 2020reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.11606/s1518-8787.2020054003278info:eu-repo/semantics/openAccessSilva,Antônio Augusto Moura daLima-Neto,Lídio GonçalvesAzevedo,Conceição de Maria Pedrozo e Silva deCosta,Léa Márcia Melo daBragança,Maylla Luanna Barbosa MartinsBarros Filho,Allan Kardec DuailibeWittlin,Bernardo BastosSouza,Bruno Feres deOliveira,Bruno Luciano Carneiro Alves deCarvalho,Carolina Abreu deThomaz,Erika Barbara Abreu FonsecaSimões-Neto,Eudes AlvesLeite Júnior,Jamesson FerreiraCosme,Lécia Maria Sousa SantosCampos,Marcos Adriano GarciaQueiroz,Rejane Christine de SousaCosta,Sérgio SouzaCarvalho,Vitória Abreu deSimões,Vanda Maria FerreiraAlves,Maria Teresa Seabra Soares de Brito eSantos,Alcione Miranda doseng2020-12-10T00:00:00Zoai:scielo:S0034-89102020000100306Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2020-12-10T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
spellingShingle |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão Silva,Antônio Augusto Moura da Seroepidemiologic Studies Coronavirus Infections Immunity, Herd Mortality |
title_short |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_full |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_fullStr |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_full_unstemmed |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
title_sort |
Population-based seroprevalence of SARS-CoV-2 and the herd immunity threshold in Maranhão |
author |
Silva,Antônio Augusto Moura da |
author_facet |
Silva,Antônio Augusto Moura da Lima-Neto,Lídio Gonçalves Azevedo,Conceição de Maria Pedrozo e Silva de Costa,Léa Márcia Melo da Bragança,Maylla Luanna Barbosa Martins Barros Filho,Allan Kardec Duailibe Wittlin,Bernardo Bastos Souza,Bruno Feres de Oliveira,Bruno Luciano Carneiro Alves de Carvalho,Carolina Abreu de Thomaz,Erika Barbara Abreu Fonseca Simões-Neto,Eudes Alves Leite Júnior,Jamesson Ferreira Cosme,Lécia Maria Sousa Santos Campos,Marcos Adriano Garcia Queiroz,Rejane Christine de Sousa Costa,Sérgio Souza Carvalho,Vitória Abreu de Simões,Vanda Maria Ferreira Alves,Maria Teresa Seabra Soares de Brito e Santos,Alcione Miranda dos |
author_role |
author |
author2 |
Lima-Neto,Lídio Gonçalves Azevedo,Conceição de Maria Pedrozo e Silva de Costa,Léa Márcia Melo da Bragança,Maylla Luanna Barbosa Martins Barros Filho,Allan Kardec Duailibe Wittlin,Bernardo Bastos Souza,Bruno Feres de Oliveira,Bruno Luciano Carneiro Alves de Carvalho,Carolina Abreu de Thomaz,Erika Barbara Abreu Fonseca Simões-Neto,Eudes Alves Leite Júnior,Jamesson Ferreira Cosme,Lécia Maria Sousa Santos Campos,Marcos Adriano Garcia Queiroz,Rejane Christine de Sousa Costa,Sérgio Souza Carvalho,Vitória Abreu de Simões,Vanda Maria Ferreira Alves,Maria Teresa Seabra Soares de Brito e Santos,Alcione Miranda dos |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Antônio Augusto Moura da Lima-Neto,Lídio Gonçalves Azevedo,Conceição de Maria Pedrozo e Silva de Costa,Léa Márcia Melo da Bragança,Maylla Luanna Barbosa Martins Barros Filho,Allan Kardec Duailibe Wittlin,Bernardo Bastos Souza,Bruno Feres de Oliveira,Bruno Luciano Carneiro Alves de Carvalho,Carolina Abreu de Thomaz,Erika Barbara Abreu Fonseca Simões-Neto,Eudes Alves Leite Júnior,Jamesson Ferreira Cosme,Lécia Maria Sousa Santos Campos,Marcos Adriano Garcia Queiroz,Rejane Christine de Sousa Costa,Sérgio Souza Carvalho,Vitória Abreu de Simões,Vanda Maria Ferreira Alves,Maria Teresa Seabra Soares de Brito e Santos,Alcione Miranda dos |
dc.subject.por.fl_str_mv |
Seroepidemiologic Studies Coronavirus Infections Immunity, Herd Mortality |
topic |
Seroepidemiologic Studies Coronavirus Infections Immunity, Herd Mortality |
description |
ABSTRACT OBJECTIVE: To estimate the seroprevalence of SARS-CoV-2 in the state of Maranhão, Brazil. METHODS: A population-based household survey was performed, from July 27, 2020 to August 8, 2020. The estimates considered clustering, stratification and non-response. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyzer (Roche Diagnostics). RESULTS: In total, 3,156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40.4% (95%CI 35.6-45.3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 26.0% were asymptomatic. The infection fatality rate (IFR) was 0.14%, higher for men and older adults. The IFR based on excess deaths was 0.28%. The ratio of estimated infections to reported cases was 22.2. CONCLUSIONS: To the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey is one of the highest reported. The local herd immunity threshold may have been reached or might be reached soon. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100306 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100306 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.11606/s1518-8787.2020054003278 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Saúde Pública da Universidade de São Paulo |
publisher.none.fl_str_mv |
Faculdade de Saúde Pública da Universidade de São Paulo |
dc.source.none.fl_str_mv |
Revista de Saúde Pública v.54 2020 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
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1748936506099105792 |