Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal

Detalhes bibliográficos
Autor(a) principal: Mota, Ana
Data de Publicação: 2010
Outros Autores: Guedes, Fátima, Areias, Jorge, Pinho, Luciana, Cardoso, Margarida Fonseca
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/32867
Resumo: OBJECTIVE: To describe the epidemiological and genotypic profile of chronic hepatitis B infection in Northern Portugal. METHODS: This survey comprised 358 subjects with positive serology for hepatitis B antigen for at least six months, recruited from specialist appointments in two hospitals in Northern Portugal between 2008 and 2009. Data were obtained from patient files, laboratory tests performed at the time of viral genotyping, echograms and/or ultrasonogram results, and liver biopsies. Demographic characteristics, viral markers, viral load and genotype, and severity of liver disease were evaluated and compared between sexes. RESULTS: Genotypes A and D were predominant in both sexes. Intrafamilial transmission occurred mostly among female patients. One-third of females and 58,9% of males showed alcohol intake above 20 g/day. Absence of AgHBe was similar in both sexes (p = 0.662). Elevated biochemical parameters and presence of necroinflammatory activity and steatosis in liver biopsies were more frequent among male patients (p=0.003). CONCLUSIONS: Differences in terms of route of HBV infection between men and women may be a consequence of gender-associated risk behaviors. Excessive alcohol intake is more frequent among males than females, as is more severe liver disease.
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spelling Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal Perfil epidemiológico y genotípico de la infección por el virus de la hepatitis B en el Norte de Portugal Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal Hepatite BepidemiologiaVírus da Hepatite Bisolamento & purificaçãoFatores de RiscoEpidemiologia DescritivaHepatitis BepidemiologíaVirus de la Hepatitis Baislamiento & purificaciónFactores de RiesgoEpidemiología DescriptivaHepatitis BepidemiologyHepatitis B virusisolation & purificationRisk FactorsEpidemiologyDescriptive OBJECTIVE: To describe the epidemiological and genotypic profile of chronic hepatitis B infection in Northern Portugal. METHODS: This survey comprised 358 subjects with positive serology for hepatitis B antigen for at least six months, recruited from specialist appointments in two hospitals in Northern Portugal between 2008 and 2009. Data were obtained from patient files, laboratory tests performed at the time of viral genotyping, echograms and/or ultrasonogram results, and liver biopsies. Demographic characteristics, viral markers, viral load and genotype, and severity of liver disease were evaluated and compared between sexes. RESULTS: Genotypes A and D were predominant in both sexes. Intrafamilial transmission occurred mostly among female patients. One-third of females and 58,9% of males showed alcohol intake above 20 g/day. Absence of AgHBe was similar in both sexes (p = 0.662). Elevated biochemical parameters and presence of necroinflammatory activity and steatosis in liver biopsies were more frequent among male patients (p=0.003). CONCLUSIONS: Differences in terms of route of HBV infection between men and women may be a consequence of gender-associated risk behaviors. Excessive alcohol intake is more frequent among males than females, as is more severe liver disease. OBJETIVO: Describir el perfil epidemiológico y genotípico de la infección crónica por el virus de la hepatitis B en la Región Norte de Portugal. MÉTODOS: Se incluyeron 358 individuos oriundos de las consultas de especialidad que presentaban resultados positivos para el antígeno de la hepatitis B durante por lo menos seis meses en dos hospitales del Norte de Portugal en 2008 y 2009. Los datos fueron obtenidos a partir de los procesos clínicos, determinaciones laboratoriales hechas a partir del genotipaje del virus, ecografía y/o ultrasonografía y biopsia hepática. Las características demográficas, marcadores virales, carga viral y genotipos, y severidad de la enfermedad hepática fueron evaluados y comparados entre sexos. RESULTADOS: Los genotipos A y D predominaron. La transmisión intrafamiliar ocurrió predominantemente en las mujeres. Un tercio de las mujeres presentaba ingestión alcohólica superior a 20g/día, aumentando para 58,9% en los hombres. La ausencia del AgHBe fue semejante en los dos sexos (p=0,662). Los parámetros bioquímicos en general se presentaron con valores más altos en los hombres, así como en las fases necro-inflamatoria y de esteatosis hepática (p=0,003). CONCLUSIONES: Las diferencias relativas a las vías de transmisión de la infección por el virus de la hepatitis B entre hombres y mujeres poden ser consecuencias de comportamientos de riego asociada al género. La ingestión de alcohol excesiva es predominante en los individuos del sexo masculino, así como mayor severidad de la enfermedad hepática con relación a las mujeres. OBJECTIVO: Descrever o perfil epidemiológico e genotípico da infecção crônica pelo vírus da hepatite B na Região Norte de Portugal. MÉTODOS: Foram incluídos 358 indivíduos oriundos das consultas de especialidade que apresentavam resultados positivos para o antígeno da hepatite B durante pelo menos seis meses em dois hospitais do Norte de Portugal em 2008 e 2009. Os dados foram obtidos a partir dos processos clínicos, determinações laboratoriais feitas quando da genotipagem do vírus, ecografia e/ou ultra-sonografia e biópsia hepática. As características demográficas, marcadores víricos, carga viral e genótipos, e severidade da doença hepática foram avaliadas e comparadas entre sexos. RESULTADOS: Os genótipos A e D predominaram. A transmissão intrafamiliar ocorreu predominantemente nas mulheres. Um terço das mulheres apresentava ingestão alcoólica superior a 20 g/dia, aumentando para 58,9% nos homens. A ausência do AgHBe foi semelhante nos dois sexos (p = 0,662). Os parâmetros bioquímicos em geral apresentaram-se com valores mais altos nos homens, assim como nos estágios necro-inflamatório e de esteatose hepática (p = 0,003). CONCLUSÕES: As diferenças relativas às vias de transmissão da infecção pelo vírus da hepatite B entre homens e mulheres podem ser conseqüência de comportamentos de risco associadas ao género. A ingestão excessiva de álcool é predominante nos indivíduos do sexo masculino, assim como maior severidade da doença hepática em relação às mulheres. Universidade de São Paulo. Faculdade de Saúde Pública2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3286710.1590/S0034-89102010000600014Revista de Saúde Pública; Vol. 44 No. 6 (2010); 1087-1093 Revista de Saúde Pública; Vol. 44 Núm. 6 (2010); 1087-1093 Revista de Saúde Pública; v. 44 n. 6 (2010); 1087-1093 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/rsp/article/view/32867/35430https://www.revistas.usp.br/rsp/article/view/32867/35431Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessMota, AnaGuedes, FátimaAreias, JorgePinho, LucianaCardoso, Margarida Fonseca2012-07-10T02:30:36Zoai:revistas.usp.br:article/32867Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-10T02:30:36Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
Perfil epidemiológico y genotípico de la infección por el virus de la hepatitis B en el Norte de Portugal
Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal
title Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
spellingShingle Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
Mota, Ana
Hepatite B
epidemiologia
Vírus da Hepatite B
isolamento & purificação
Fatores de Risco
Epidemiologia Descritiva
Hepatitis B
epidemiología
Virus de la Hepatitis B
aislamiento & purificación
Factores de Riesgo
Epidemiología Descriptiva
Hepatitis B
epidemiology
Hepatitis B virus
isolation & purification
Risk Factors
Epidemiology
Descriptive
title_short Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
title_full Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
title_fullStr Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
title_full_unstemmed Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
title_sort Epidemiological and genotypic profile of hepatitis B virus infection in Northern Portugal
author Mota, Ana
author_facet Mota, Ana
Guedes, Fátima
Areias, Jorge
Pinho, Luciana
Cardoso, Margarida Fonseca
author_role author
author2 Guedes, Fátima
Areias, Jorge
Pinho, Luciana
Cardoso, Margarida Fonseca
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mota, Ana
Guedes, Fátima
Areias, Jorge
Pinho, Luciana
Cardoso, Margarida Fonseca
dc.subject.por.fl_str_mv Hepatite B
epidemiologia
Vírus da Hepatite B
isolamento & purificação
Fatores de Risco
Epidemiologia Descritiva
Hepatitis B
epidemiología
Virus de la Hepatitis B
aislamiento & purificación
Factores de Riesgo
Epidemiología Descriptiva
Hepatitis B
epidemiology
Hepatitis B virus
isolation & purification
Risk Factors
Epidemiology
Descriptive
topic Hepatite B
epidemiologia
Vírus da Hepatite B
isolamento & purificação
Fatores de Risco
Epidemiologia Descritiva
Hepatitis B
epidemiología
Virus de la Hepatitis B
aislamiento & purificación
Factores de Riesgo
Epidemiología Descriptiva
Hepatitis B
epidemiology
Hepatitis B virus
isolation & purification
Risk Factors
Epidemiology
Descriptive
description OBJECTIVE: To describe the epidemiological and genotypic profile of chronic hepatitis B infection in Northern Portugal. METHODS: This survey comprised 358 subjects with positive serology for hepatitis B antigen for at least six months, recruited from specialist appointments in two hospitals in Northern Portugal between 2008 and 2009. Data were obtained from patient files, laboratory tests performed at the time of viral genotyping, echograms and/or ultrasonogram results, and liver biopsies. Demographic characteristics, viral markers, viral load and genotype, and severity of liver disease were evaluated and compared between sexes. RESULTS: Genotypes A and D were predominant in both sexes. Intrafamilial transmission occurred mostly among female patients. One-third of females and 58,9% of males showed alcohol intake above 20 g/day. Absence of AgHBe was similar in both sexes (p = 0.662). Elevated biochemical parameters and presence of necroinflammatory activity and steatosis in liver biopsies were more frequent among male patients (p=0.003). CONCLUSIONS: Differences in terms of route of HBV infection between men and women may be a consequence of gender-associated risk behaviors. Excessive alcohol intake is more frequent among males than females, as is more severe liver disease.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32867
10.1590/S0034-89102010000600014
url https://www.revistas.usp.br/rsp/article/view/32867
identifier_str_mv 10.1590/S0034-89102010000600014
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32867/35430
https://www.revistas.usp.br/rsp/article/view/32867/35431
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 44 No. 6 (2010); 1087-1093
Revista de Saúde Pública; Vol. 44 Núm. 6 (2010); 1087-1093
Revista de Saúde Pública; v. 44 n. 6 (2010); 1087-1093
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
_version_ 1800221791203885056

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