Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius

Detalhes bibliográficos
Autor(a) principal: Cardoso, Priscylla Maria Martins
Data de Publicação: 2020
Outros Autores: Mazuco, Renata Alves, Macedo, Lucas Soares Dazzi, Polese, Ariele Abreu Venturini, Barroso, Maria Eduarda de Souza, Baratella, Waléria Gramilich, Andrade, Tadeu Uggere de, Lenz, Dominik, Pereira, Thiago de Melo Costa, Endringer, Denise Coutinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/181419
Resumo: Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.
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spelling Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis MartiusNephroprotectionEuterpe edulis MartiusPolyphenolsAnthocyaninsAntioxidant activityContrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18141910.1590/s2175-97902019000318051Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18051Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18051Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e180512175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181419/168361Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardoso, Priscylla Maria Martins Mazuco, Renata Alves Macedo, Lucas Soares Dazzi Polese, Ariele Abreu Venturini Barroso, Maria Eduarda de Souza Baratella, Waléria Gramilich Andrade, Tadeu Uggere de Lenz, Dominik Pereira, Thiago de Melo Costa Endringer, Denise Coutinho 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181419Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
title Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
spellingShingle Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
Cardoso, Priscylla Maria Martins
Nephroprotection
Euterpe edulis Martius
Polyphenols
Anthocyanins
Antioxidant activity
title_short Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
title_full Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
title_fullStr Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
title_full_unstemmed Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
title_sort Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
author Cardoso, Priscylla Maria Martins
author_facet Cardoso, Priscylla Maria Martins
Mazuco, Renata Alves
Macedo, Lucas Soares Dazzi
Polese, Ariele Abreu Venturini
Barroso, Maria Eduarda de Souza
Baratella, Waléria Gramilich
Andrade, Tadeu Uggere de
Lenz, Dominik
Pereira, Thiago de Melo Costa
Endringer, Denise Coutinho
author_role author
author2 Mazuco, Renata Alves
Macedo, Lucas Soares Dazzi
Polese, Ariele Abreu Venturini
Barroso, Maria Eduarda de Souza
Baratella, Waléria Gramilich
Andrade, Tadeu Uggere de
Lenz, Dominik
Pereira, Thiago de Melo Costa
Endringer, Denise Coutinho
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cardoso, Priscylla Maria Martins
Mazuco, Renata Alves
Macedo, Lucas Soares Dazzi
Polese, Ariele Abreu Venturini
Barroso, Maria Eduarda de Souza
Baratella, Waléria Gramilich
Andrade, Tadeu Uggere de
Lenz, Dominik
Pereira, Thiago de Melo Costa
Endringer, Denise Coutinho
dc.subject.por.fl_str_mv Nephroprotection
Euterpe edulis Martius
Polyphenols
Anthocyanins
Antioxidant activity
topic Nephroprotection
Euterpe edulis Martius
Polyphenols
Anthocyanins
Antioxidant activity
description Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181419
10.1590/s2175-97902019000318051
url https://www.revistas.usp.br/bjps/article/view/181419
identifier_str_mv 10.1590/s2175-97902019000318051
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181419/168361
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18051
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18051
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18051
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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