Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/181419 |
Resumo: | Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp. |
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oai:revistas.usp.br:article/181419 |
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USP-31 |
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Brazilian Journal of Pharmaceutical Sciences |
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Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis MartiusNephroprotectionEuterpe edulis MartiusPolyphenolsAnthocyaninsAntioxidant activityContrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18141910.1590/s2175-97902019000318051Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18051Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18051Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e180512175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181419/168361Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCardoso, Priscylla Maria Martins Mazuco, Renata Alves Macedo, Lucas Soares Dazzi Polese, Ariele Abreu Venturini Barroso, Maria Eduarda de Souza Baratella, Waléria Gramilich Andrade, Tadeu Uggere de Lenz, Dominik Pereira, Thiago de Melo Costa Endringer, Denise Coutinho 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181419Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
title |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
spellingShingle |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius Cardoso, Priscylla Maria Martins Nephroprotection Euterpe edulis Martius Polyphenols Anthocyanins Antioxidant activity |
title_short |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
title_full |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
title_fullStr |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
title_full_unstemmed |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
title_sort |
Nephroprotective activity of the enriched polyphenol extract of Euterpe edulis Martius |
author |
Cardoso, Priscylla Maria Martins |
author_facet |
Cardoso, Priscylla Maria Martins Mazuco, Renata Alves Macedo, Lucas Soares Dazzi Polese, Ariele Abreu Venturini Barroso, Maria Eduarda de Souza Baratella, Waléria Gramilich Andrade, Tadeu Uggere de Lenz, Dominik Pereira, Thiago de Melo Costa Endringer, Denise Coutinho |
author_role |
author |
author2 |
Mazuco, Renata Alves Macedo, Lucas Soares Dazzi Polese, Ariele Abreu Venturini Barroso, Maria Eduarda de Souza Baratella, Waléria Gramilich Andrade, Tadeu Uggere de Lenz, Dominik Pereira, Thiago de Melo Costa Endringer, Denise Coutinho |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cardoso, Priscylla Maria Martins Mazuco, Renata Alves Macedo, Lucas Soares Dazzi Polese, Ariele Abreu Venturini Barroso, Maria Eduarda de Souza Baratella, Waléria Gramilich Andrade, Tadeu Uggere de Lenz, Dominik Pereira, Thiago de Melo Costa Endringer, Denise Coutinho |
dc.subject.por.fl_str_mv |
Nephroprotection Euterpe edulis Martius Polyphenols Anthocyanins Antioxidant activity |
topic |
Nephroprotection Euterpe edulis Martius Polyphenols Anthocyanins Antioxidant activity |
description |
Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1- picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181419 10.1590/s2175-97902019000318051 |
url |
https://www.revistas.usp.br/bjps/article/view/181419 |
identifier_str_mv |
10.1590/s2175-97902019000318051 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181419/168361 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18051 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18051 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18051 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915066593280 |