In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/205068 |
Resumo: | Traditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity against lung cancer cell line (A549). FTIR result of synthesised AgNPs reveals the presence of functional group OH as capping agent. XRD pattern confirms the crystalline nature of the AgNPs with peaks at 38º, 44º, 64º and 81º, indexed by (111), (200), (220) and (222) in the 2θ range of 10-90, indicating the face centered cubic (fcc) structure of metallic Ag. HR- TEM results confirm the morphology of AgNPs as almost spherical with high surface areas and average size of 42 ± 9nm. EDX spectra confirmed that Ag is only the major element present and the Dynamic light scattering (DLS) assisted that the Z-average size was 203nm and 1.0 of PdI value. Zeta potential showed − 26.5mv with a single peak. The results of the biological activities of AgNPs exhibited dose dependent activity with 68.44% for arthritic, antiinflammatory with 63.32% inhibition and anti-proliferative activity illustrated IC50 value of 59.66 μg/mL expressing the potential of AgNPs to combat cancer. |
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Brazilian Journal of Pharmaceutical Sciences |
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In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates)NanoparticlesProliferationInflammatoryArthriticGreen synthesisAnticancerTraditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity against lung cancer cell line (A549). FTIR result of synthesised AgNPs reveals the presence of functional group OH as capping agent. XRD pattern confirms the crystalline nature of the AgNPs with peaks at 38º, 44º, 64º and 81º, indexed by (111), (200), (220) and (222) in the 2θ range of 10-90, indicating the face centered cubic (fcc) structure of metallic Ag. HR- TEM results confirm the morphology of AgNPs as almost spherical with high surface areas and average size of 42 ± 9nm. EDX spectra confirmed that Ag is only the major element present and the Dynamic light scattering (DLS) assisted that the Z-average size was 203nm and 1.0 of PdI value. Zeta potential showed − 26.5mv with a single peak. The results of the biological activities of AgNPs exhibited dose dependent activity with 68.44% for arthritic, antiinflammatory with 63.32% inhibition and anti-proliferative activity illustrated IC50 value of 59.66 μg/mL expressing the potential of AgNPs to combat cancer.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-03-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20506810.1590/s2175-97902022e18594 Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/205068/194453https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Zameer Ahmed Khader, SyedSyed Zameer Ahmed, SidhraRafi Mahboob, MohamedBarathi Prabaharan, SelvaOlapalayam Lakshmanan, ShanmugasundaramRamesh Kumar, KishoreDavid, Daniel2023-05-25T13:20:50Zoai:revistas.usp.br:article/205068Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-25T13:20:50Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
title |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
spellingShingle |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) Zameer Ahmed Khader, Syed Nanoparticles Proliferation Inflammatory Arthritic Green synthesis Anticancer |
title_short |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
title_full |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
title_fullStr |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
title_full_unstemmed |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
title_sort |
In vitro anti-inflammatory, anti-arthritic and antiproliferative activity of green synthesized silver nanoparticles - Phoenix dactylifera (Rothan dates) |
author |
Zameer Ahmed Khader, Syed |
author_facet |
Zameer Ahmed Khader, Syed Syed Zameer Ahmed, Sidhra Rafi Mahboob, Mohamed Barathi Prabaharan, Selva Olapalayam Lakshmanan, Shanmugasundaram Ramesh Kumar, Kishore David, Daniel |
author_role |
author |
author2 |
Syed Zameer Ahmed, Sidhra Rafi Mahboob, Mohamed Barathi Prabaharan, Selva Olapalayam Lakshmanan, Shanmugasundaram Ramesh Kumar, Kishore David, Daniel |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Zameer Ahmed Khader, Syed Syed Zameer Ahmed, Sidhra Rafi Mahboob, Mohamed Barathi Prabaharan, Selva Olapalayam Lakshmanan, Shanmugasundaram Ramesh Kumar, Kishore David, Daniel |
dc.subject.por.fl_str_mv |
Nanoparticles Proliferation Inflammatory Arthritic Green synthesis Anticancer |
topic |
Nanoparticles Proliferation Inflammatory Arthritic Green synthesis Anticancer |
description |
Traditionally dates is consumed as a rich source of iron supplement and the current research discuss the synthesis of silver nanoparticles (AgNPs) using methanolic seed extract of Rothan date and its application over in vitro anti-arthritic, anti-inflammatory and antiproliferative activity against lung cancer cell line (A549). FTIR result of synthesised AgNPs reveals the presence of functional group OH as capping agent. XRD pattern confirms the crystalline nature of the AgNPs with peaks at 38º, 44º, 64º and 81º, indexed by (111), (200), (220) and (222) in the 2θ range of 10-90, indicating the face centered cubic (fcc) structure of metallic Ag. HR- TEM results confirm the morphology of AgNPs as almost spherical with high surface areas and average size of 42 ± 9nm. EDX spectra confirmed that Ag is only the major element present and the Dynamic light scattering (DLS) assisted that the Z-average size was 203nm and 1.0 of PdI value. Zeta potential showed − 26.5mv with a single peak. The results of the biological activities of AgNPs exhibited dose dependent activity with 68.44% for arthritic, antiinflammatory with 63.32% inhibition and anti-proliferative activity illustrated IC50 value of 59.66 μg/mL expressing the potential of AgNPs to combat cancer. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/205068 10.1590/s2175-97902022e18594 |
url |
https://www.revistas.usp.br/bjps/article/view/205068 |
identifier_str_mv |
10.1590/s2175-97902022e18594 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/205068/194453 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222916527259648 |