The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/210970 |
Resumo: | Ischemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol. |
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Brazilian Journal of Pharmaceutical Sciences |
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The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in RatsFree Radical; Antioxidant; Geraniol; Ischemia Reperfusion; KidneyIschemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21097010.1590/s2175-97902023e21248Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21248Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21248Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e212482175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/210970/194559https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessSeren DanışSenanur CanFatma YıldızIşıl Tan YılmazMediha CanbekAyşe Özmen Yaylacı2023-05-29T19:54:20Zoai:revistas.usp.br:article/210970Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-29T19:54:20Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
title |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
spellingShingle |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats Seren Danış Free Radical; Antioxidant; Geraniol; Ischemia Reperfusion; Kidney |
title_short |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
title_full |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
title_fullStr |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
title_full_unstemmed |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
title_sort |
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats |
author |
Seren Danış |
author_facet |
Seren Danış Senanur Can Fatma Yıldız Işıl Tan Yılmaz Mediha Canbek Ayşe Özmen Yaylacı |
author_role |
author |
author2 |
Senanur Can Fatma Yıldız Işıl Tan Yılmaz Mediha Canbek Ayşe Özmen Yaylacı |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Seren Danış Senanur Can Fatma Yıldız Işıl Tan Yılmaz Mediha Canbek Ayşe Özmen Yaylacı |
dc.subject.por.fl_str_mv |
Free Radical; Antioxidant; Geraniol; Ischemia Reperfusion; Kidney |
topic |
Free Radical; Antioxidant; Geraniol; Ischemia Reperfusion; Kidney |
description |
Ischemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210970 10.1590/s2175-97902023e21248 |
url |
https://www.revistas.usp.br/bjps/article/view/210970 |
identifier_str_mv |
10.1590/s2175-97902023e21248 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210970/194559 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21248 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21248 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21248 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222918007848960 |