Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/164517 |
Resumo: | The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery. |
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Brazilian Journal of Pharmaceutical Sciences |
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Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug deliveryOcular drug deliveryNanoparticlesCorneal penetrationOfloxacinChitosanThe efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16451710.1590/s2175-97902019000117105Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17105Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17105Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e171052175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/164517/157767Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTaghe, ShivaMirzaeei, Shahla2021-01-11T17:50:58Zoai:revistas.usp.br:article/164517Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-11T17:50:58Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
title |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
spellingShingle |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery Taghe, Shiva Ocular drug delivery Nanoparticles Corneal penetration Ofloxacin Chitosan |
title_short |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
title_full |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
title_fullStr |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
title_full_unstemmed |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
title_sort |
Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery |
author |
Taghe, Shiva |
author_facet |
Taghe, Shiva Mirzaeei, Shahla |
author_role |
author |
author2 |
Mirzaeei, Shahla |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Taghe, Shiva Mirzaeei, Shahla |
dc.subject.por.fl_str_mv |
Ocular drug delivery Nanoparticles Corneal penetration Ofloxacin Chitosan |
topic |
Ocular drug delivery Nanoparticles Corneal penetration Ofloxacin Chitosan |
description |
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A modified ionotropic gelation method was used to produce ofloxacin-loaded nanoreservoir systems. The ofloxacin-loaded CS/TPP and CS/TPP-ALG nanoparticles were characterized for particle size, morphology, zeta potential, encapsulation efficiency, subsequent release and corneal penetration study. The designed nanoparticles have a particle size from 113.8 nm to 509 nm and zeta potential from 16.2 mV to 40.3 mV and encapsulation efficiency values ranging from 19.7% to 33.1%. Nanoparticles revealed a release during the first hours, followed by a more gradual drug release. The ofloxacin-loading CS/TPP or CS/TPP-ALG NPs developed are pronounced penetration enhancing effect as compared to OFX solution (5-6.5 times). Thus, these nanoparticles have a strong potential for ocular drug delivery. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164517 10.1590/s2175-97902019000117105 |
url |
https://www.revistas.usp.br/bjps/article/view/164517 |
identifier_str_mv |
10.1590/s2175-97902019000117105 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164517/157767 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17105 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17105 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17105 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222914446884864 |