Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

Detalhes bibliográficos
Autor(a) principal: Lima, Monica Força
Data de Publicação: 2017
Outros Autores: Cassella, Ricardo Jorgensen, Pacheco, Wagner Felippe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/134899
Resumo: This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).
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spelling Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarinRosuvastatin/spectrophotometric determinationRosuvastatin/charge transfer complexQuinalizarin/charge transfer complexPharmaceutical formulations. This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/13489910.1590/s2175-97902017000300075Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 3 (2017); e00075Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 3 (2017); e00075Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 3 (2017); e000752175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/134899/130646Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessLima, Monica ForçaCassella, Ricardo JorgensenPacheco, Wagner Felippe2017-10-27T12:12:57Zoai:revistas.usp.br:article/134899Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2017-10-27T12:12:57Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
title Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
spellingShingle Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
Lima, Monica Força
Rosuvastatin/spectrophotometric determination
Rosuvastatin/charge transfer complex
Quinalizarin/charge transfer complex
Pharmaceutical formulations.
title_short Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
title_full Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
title_fullStr Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
title_full_unstemmed Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
title_sort Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
author Lima, Monica Força
author_facet Lima, Monica Força
Cassella, Ricardo Jorgensen
Pacheco, Wagner Felippe
author_role author
author2 Cassella, Ricardo Jorgensen
Pacheco, Wagner Felippe
author2_role author
author
dc.contributor.author.fl_str_mv Lima, Monica Força
Cassella, Ricardo Jorgensen
Pacheco, Wagner Felippe
dc.subject.por.fl_str_mv Rosuvastatin/spectrophotometric determination
Rosuvastatin/charge transfer complex
Quinalizarin/charge transfer complex
Pharmaceutical formulations.
topic Rosuvastatin/spectrophotometric determination
Rosuvastatin/charge transfer complex
Quinalizarin/charge transfer complex
Pharmaceutical formulations.
description This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/134899
10.1590/s2175-97902017000300075
url https://www.revistas.usp.br/bjps/article/view/134899
identifier_str_mv 10.1590/s2175-97902017000300075
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/134899/130646
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 3 (2017); e00075
Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 3 (2017); e00075
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 3 (2017); e00075
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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