Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/134899 |
Resumo: | This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference). |
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oai:revistas.usp.br:article/134899 |
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USP-31 |
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Brazilian Journal of Pharmaceutical Sciences |
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Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarinRosuvastatin/spectrophotometric determinationRosuvastatin/charge transfer complexQuinalizarin/charge transfer complexPharmaceutical formulations. This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/13489910.1590/s2175-97902017000300075Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 3 (2017); e00075Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 3 (2017); e00075Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 3 (2017); e000752175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/134899/130646Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessLima, Monica ForçaCassella, Ricardo JorgensenPacheco, Wagner Felippe2017-10-27T12:12:57Zoai:revistas.usp.br:article/134899Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2017-10-27T12:12:57Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
title |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
spellingShingle |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin Lima, Monica Força Rosuvastatin/spectrophotometric determination Rosuvastatin/charge transfer complex Quinalizarin/charge transfer complex Pharmaceutical formulations. |
title_short |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
title_full |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
title_fullStr |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
title_full_unstemmed |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
title_sort |
Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin |
author |
Lima, Monica Força |
author_facet |
Lima, Monica Força Cassella, Ricardo Jorgensen Pacheco, Wagner Felippe |
author_role |
author |
author2 |
Cassella, Ricardo Jorgensen Pacheco, Wagner Felippe |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Lima, Monica Força Cassella, Ricardo Jorgensen Pacheco, Wagner Felippe |
dc.subject.por.fl_str_mv |
Rosuvastatin/spectrophotometric determination Rosuvastatin/charge transfer complex Quinalizarin/charge transfer complex Pharmaceutical formulations. |
topic |
Rosuvastatin/spectrophotometric determination Rosuvastatin/charge transfer complex Quinalizarin/charge transfer complex Pharmaceutical formulations. |
description |
This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L-1. The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L-1), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference). |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/134899 10.1590/s2175-97902017000300075 |
url |
https://www.revistas.usp.br/bjps/article/view/134899 |
identifier_str_mv |
10.1590/s2175-97902017000300075 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/134899/130646 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 3 (2017); e00075 Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 3 (2017); e00075 Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 3 (2017); e00075 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1821325161672998912 |