Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/211887 |
Resumo: | Dill (Anethum graveolens L.) essential oil is wide spread in the food, beverage and pharmaceutical sectors. Dill is a member of the Apiaceae (Umbelliferae) family. It has the following biological activities: antioxidant, antifungal, antibacterial, antimicrobial, antihyperlipidemic, antihypercholesterolemic, antispasmodic, antiproliferative and anti-inflammatory. Aqueous extract of dill seed has reported effects on sex hormones and infertility potential. Moreover, boiled dill seed has an impact on reducing labor duration in giving birth. Implantation and placentation are necessary for a healthy pregnancy in the early stages. Angiogenesis is responsible for these essential processes. This study aimed to investigate dill seed oil’s cytotoxic and antiangiogenic effects on rat adipose tissue endothelial cells (RATECs). Dill seed oil showed dose-dependent cytotoxicity on RATECs. It disrupted endothelial tube formation and depolymerized F-actin stress fibers. According to this study, depolymerization of F-actin stress fiber by dill seed oil could inhibit angiogenesis by suppressing endothelial cell proliferation, tube formation and motility. In other words, dill seed oil can be a new anti-angiogenic agent and a novel contraceptive. |
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Brazilian Journal of Pharmaceutical Sciences |
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Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cellsAnethum graveolens; Angiogenesis; Dill seed oil; Endothelial cells; ContraceptiveDill (Anethum graveolens L.) essential oil is wide spread in the food, beverage and pharmaceutical sectors. Dill is a member of the Apiaceae (Umbelliferae) family. It has the following biological activities: antioxidant, antifungal, antibacterial, antimicrobial, antihyperlipidemic, antihypercholesterolemic, antispasmodic, antiproliferative and anti-inflammatory. Aqueous extract of dill seed has reported effects on sex hormones and infertility potential. Moreover, boiled dill seed has an impact on reducing labor duration in giving birth. Implantation and placentation are necessary for a healthy pregnancy in the early stages. Angiogenesis is responsible for these essential processes. This study aimed to investigate dill seed oil’s cytotoxic and antiangiogenic effects on rat adipose tissue endothelial cells (RATECs). Dill seed oil showed dose-dependent cytotoxicity on RATECs. It disrupted endothelial tube formation and depolymerized F-actin stress fibers. According to this study, depolymerization of F-actin stress fiber by dill seed oil could inhibit angiogenesis by suppressing endothelial cell proliferation, tube formation and motility. In other words, dill seed oil can be a new anti-angiogenic agent and a novel contraceptive.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-05-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21188710.1590/s2175-97902023e20060Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20060Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e20060Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e200602175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/211887/194720https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessUlus, GönülZeytinoğlu, MelihKürkçüoğlu, MineBaşer, Kemal Hüsnü CanAyşe Tansu, Koparal 2023-06-02T21:33:02Zoai:revistas.usp.br:article/211887Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-06-02T21:33:02Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
title |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
spellingShingle |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells Ulus, Gönül Anethum graveolens; Angiogenesis; Dill seed oil; Endothelial cells; Contraceptive |
title_short |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
title_full |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
title_fullStr |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
title_full_unstemmed |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
title_sort |
Dill seed oil as a possible contraceptive agent: antiangiogenic effects on endothelial cells |
author |
Ulus, Gönül |
author_facet |
Ulus, Gönül Zeytinoğlu, Melih Kürkçüoğlu, Mine Başer, Kemal Hüsnü Can Ayşe Tansu, Koparal |
author_role |
author |
author2 |
Zeytinoğlu, Melih Kürkçüoğlu, Mine Başer, Kemal Hüsnü Can Ayşe Tansu, Koparal |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Ulus, Gönül Zeytinoğlu, Melih Kürkçüoğlu, Mine Başer, Kemal Hüsnü Can Ayşe Tansu, Koparal |
dc.subject.por.fl_str_mv |
Anethum graveolens; Angiogenesis; Dill seed oil; Endothelial cells; Contraceptive |
topic |
Anethum graveolens; Angiogenesis; Dill seed oil; Endothelial cells; Contraceptive |
description |
Dill (Anethum graveolens L.) essential oil is wide spread in the food, beverage and pharmaceutical sectors. Dill is a member of the Apiaceae (Umbelliferae) family. It has the following biological activities: antioxidant, antifungal, antibacterial, antimicrobial, antihyperlipidemic, antihypercholesterolemic, antispasmodic, antiproliferative and anti-inflammatory. Aqueous extract of dill seed has reported effects on sex hormones and infertility potential. Moreover, boiled dill seed has an impact on reducing labor duration in giving birth. Implantation and placentation are necessary for a healthy pregnancy in the early stages. Angiogenesis is responsible for these essential processes. This study aimed to investigate dill seed oil’s cytotoxic and antiangiogenic effects on rat adipose tissue endothelial cells (RATECs). Dill seed oil showed dose-dependent cytotoxicity on RATECs. It disrupted endothelial tube formation and depolymerized F-actin stress fibers. According to this study, depolymerization of F-actin stress fiber by dill seed oil could inhibit angiogenesis by suppressing endothelial cell proliferation, tube formation and motility. In other words, dill seed oil can be a new anti-angiogenic agent and a novel contraceptive. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211887 10.1590/s2175-97902023e20060 |
url |
https://www.revistas.usp.br/bjps/article/view/211887 |
identifier_str_mv |
10.1590/s2175-97902023e20060 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211887/194720 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20060 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e20060 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20060 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222918062374912 |