Nitric oxide release using natural rubber latex as matrix

Detalhes bibliográficos
Autor(a) principal: Herculano,Rondinelli Donizetti
Data de Publicação: 2011
Outros Autores: Tzu,Lee Chen, Silva,Cecilia Pereira, Brunello,Carlos Alberto, Queiroz,Álvaro Antônio Alencar de, Kinoshita,Angela, Graeff,Carlos Frederico de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392011000300012
Resumo: Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.
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spelling Nitric oxide release using natural rubber latex as matrixnitric oxidelatex membranebiomaterialsdrug delivery systemNitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.ABM, ABC, ABPol2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392011000300012Materials Research v.14 n.3 2011reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392011005000055info:eu-repo/semantics/openAccessHerculano,Rondinelli DonizettiTzu,Lee ChenSilva,Cecilia PereiraBrunello,Carlos AlbertoQueiroz,Álvaro Antônio Alencar deKinoshita,AngelaGraeff,Carlos Frederico de Oliveiraeng2011-10-18T00:00:00Zoai:scielo:S1516-14392011000300012Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2011-10-18T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Nitric oxide release using natural rubber latex as matrix
title Nitric oxide release using natural rubber latex as matrix
spellingShingle Nitric oxide release using natural rubber latex as matrix
Herculano,Rondinelli Donizetti
nitric oxide
latex membrane
biomaterials
drug delivery system
title_short Nitric oxide release using natural rubber latex as matrix
title_full Nitric oxide release using natural rubber latex as matrix
title_fullStr Nitric oxide release using natural rubber latex as matrix
title_full_unstemmed Nitric oxide release using natural rubber latex as matrix
title_sort Nitric oxide release using natural rubber latex as matrix
author Herculano,Rondinelli Donizetti
author_facet Herculano,Rondinelli Donizetti
Tzu,Lee Chen
Silva,Cecilia Pereira
Brunello,Carlos Alberto
Queiroz,Álvaro Antônio Alencar de
Kinoshita,Angela
Graeff,Carlos Frederico de Oliveira
author_role author
author2 Tzu,Lee Chen
Silva,Cecilia Pereira
Brunello,Carlos Alberto
Queiroz,Álvaro Antônio Alencar de
Kinoshita,Angela
Graeff,Carlos Frederico de Oliveira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Herculano,Rondinelli Donizetti
Tzu,Lee Chen
Silva,Cecilia Pereira
Brunello,Carlos Alberto
Queiroz,Álvaro Antônio Alencar de
Kinoshita,Angela
Graeff,Carlos Frederico de Oliveira
dc.subject.por.fl_str_mv nitric oxide
latex membrane
biomaterials
drug delivery system
topic nitric oxide
latex membrane
biomaterials
drug delivery system
description Nitric oxide (NO) is a diffusible messenger that has been involved in numerous physiological processes ranging from vasodilatation and antimicrobial properties to wound healing. The beneficial effects can be attributed to the role NO plays in angiogenesis, inflammation and tissue remodeling. In the present work, a polymeric device for the sustained site specific delivery of nitric oxide using a latex rubber matrix from Hevea brasiliensis which encapsulates the spin trap iron(II)- diethyldithiocarbamate complex (FeDETC) was developed. The release profiles of NO from latex rubber matrix were studied and stability studies were carried out. Electron Paramagnetic Resonance (EPR) signal of NO was detected in the membrane exposed to ambient atmosphere at room temperature (25 °C) even after 350 hours. FTIR spectroscopy data indicated that NO-FeDETC retained its structural and spectroscopic properties upon encapsulation in the latex matrix. The NO delivery system developed in this work as a membrane, presented high stability.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392011000300012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392011000300012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-14392011005000055
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.14 n.3 2011
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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