Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models

Detalhes bibliográficos
Autor(a) principal: Reckziegel, Ramiro de Freitas Xavier
Data de Publicação: 2022
Outros Autores: Czepielewski, Letícia Sanguinetti, Sousa, Mathias Hasse de, Martins, Dayane Santos, Britto, Maria J. de, Lapa, Clara de Oliveira, Schwartzhaupt, Alexandre Willi, Gama, Clarissa Severino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/255590
Resumo: The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
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spelling Reckziegel, Ramiro de Freitas XavierCzepielewski, Letícia SanguinettiSousa, Mathias Hasse deMartins, Dayane SantosBritto, Maria J. deLapa, Clara de OliveiraSchwartzhaupt, Alexandre WilliGama, Clarissa Severino2023-03-11T03:28:17Z20221516-4446http://hdl.handle.net/10183/255590001162615The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 44, n. 1 (jan./feb. 2022), p. 74-80EsquizofreniaEnvelhecimentoProcessos cognitivosSchizophreniaCognitionAgingNeurodevelopmentNeuroprogressionHeterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression modelsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001162615.pdf.txt001162615.pdf.txtExtracted Texttext/plain44210http://www.lume.ufrgs.br/bitstream/10183/255590/2/001162615.pdf.txt0e41a3c07209fe979155f1ab6660c9b2MD52ORIGINAL001162615.pdfTexto completo (inglês)application/pdf169615http://www.lume.ufrgs.br/bitstream/10183/255590/1/001162615.pdff2599fa9598bd6a9abe30c9f47d1a074MD5110183/2555902023-03-12 03:23:40.769361oai:www.lume.ufrgs.br:10183/255590Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-03-12T06:23:40Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
title Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
spellingShingle Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
Reckziegel, Ramiro de Freitas Xavier
Esquizofrenia
Envelhecimento
Processos cognitivos
Schizophrenia
Cognition
Aging
Neurodevelopment
Neuroprogression
title_short Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
title_full Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
title_fullStr Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
title_full_unstemmed Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
title_sort Heterogeneous trajectories in schizophrenia : insights from neurodevelopment and neuroprogression models
author Reckziegel, Ramiro de Freitas Xavier
author_facet Reckziegel, Ramiro de Freitas Xavier
Czepielewski, Letícia Sanguinetti
Sousa, Mathias Hasse de
Martins, Dayane Santos
Britto, Maria J. de
Lapa, Clara de Oliveira
Schwartzhaupt, Alexandre Willi
Gama, Clarissa Severino
author_role author
author2 Czepielewski, Letícia Sanguinetti
Sousa, Mathias Hasse de
Martins, Dayane Santos
Britto, Maria J. de
Lapa, Clara de Oliveira
Schwartzhaupt, Alexandre Willi
Gama, Clarissa Severino
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reckziegel, Ramiro de Freitas Xavier
Czepielewski, Letícia Sanguinetti
Sousa, Mathias Hasse de
Martins, Dayane Santos
Britto, Maria J. de
Lapa, Clara de Oliveira
Schwartzhaupt, Alexandre Willi
Gama, Clarissa Severino
dc.subject.por.fl_str_mv Esquizofrenia
Envelhecimento
Processos cognitivos
topic Esquizofrenia
Envelhecimento
Processos cognitivos
Schizophrenia
Cognition
Aging
Neurodevelopment
Neuroprogression
dc.subject.eng.fl_str_mv Schizophrenia
Cognition
Aging
Neurodevelopment
Neuroprogression
description The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-03-11T03:28:17Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/255590
dc.identifier.issn.pt_BR.fl_str_mv 1516-4446
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Revista brasileira de psiquiatria (1999). São Paulo. Vol. 44, n. 1 (jan./feb. 2022), p. 74-80
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