Treatment of bipolar disorder in the elderly: a review of the literature

Detalhes bibliográficos
Autor(a) principal: Alves, Gilberto Sousa
Data de Publicação: 2017
Outros Autores: Sudo, Felipe Kenji, Briand, Lucas, Pantel, Johannes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Debates em Psiquiatria (Online)
Texto Completo: https://revistardp.org.br/revista/article/view/70
Resumo: Bipolar disorder (BAD) is a potentially severe condition characterized by mood shifts and cognitive and functional dysfunction. This article reviews updated evidence on the pharmacological and non-drug interventions for BD in the elderly. Evidence-based guidelines, although useful in promoting rational and effective therapy, are still relatively scarce for BD in aged individuals. Current recommendations for acute mania include the use ofatypical antipsychotics (e.g., risperidone, quetiapine, olanzapine), lithium (with judicious administration), and the choice of valproate as a gold standard therapy. In acute BD depression, first-line monotherapy agents may include lithium, lamotrigine, quetiapine, and extendedrelease quetiapine (XR). Regarding the choice of the ideal mood stabilizer, the greater potential for side effects associated with lithium has discouraged its prescription in elderly individuals. Electroconvulsive therapy, although limited by the evidence available, may be an option for severe/refractory cases.
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spelling Treatment of bipolar disorder in the elderly: a review of the literatureTratamento do transtorno bipolar no idoso: uma revisão da literaturaBipolaridosotratamentomaniadepressãoenvelhecimentoBipolarelderlytreatmentmaniadepressionagingBipolar disorder (BAD) is a potentially severe condition characterized by mood shifts and cognitive and functional dysfunction. This article reviews updated evidence on the pharmacological and non-drug interventions for BD in the elderly. Evidence-based guidelines, although useful in promoting rational and effective therapy, are still relatively scarce for BD in aged individuals. Current recommendations for acute mania include the use ofatypical antipsychotics (e.g., risperidone, quetiapine, olanzapine), lithium (with judicious administration), and the choice of valproate as a gold standard therapy. In acute BD depression, first-line monotherapy agents may include lithium, lamotrigine, quetiapine, and extendedrelease quetiapine (XR). Regarding the choice of the ideal mood stabilizer, the greater potential for side effects associated with lithium has discouraged its prescription in elderly individuals. Electroconvulsive therapy, although limited by the evidence available, may be an option for severe/refractory cases.O transtorno afetivo bipolar (TAB) é uma condição potencialmente grave, caracterizada por mudanças de humor e disfunção cognitiva e funcional. O presente artigo revisa as evidências atualizadas das intervenções farmacológicas e não medicamentosas direcionadas ao TAB em idosos. Diretrizes baseadas em evidências, embora sejam úteis na promoção de uma terapia racional e eficaz, ainda são relativamente reduzidas no TAB em idosos. As recomendações atuais para mania aguda incluem o uso de antipsicóticos atípicos (por exemplo, risperidona, quetiapina, olanzapina), lítio (de maneira criteriosa) e a eleição de valproato como terapia padrão ouro. Na depressão aguda do TAB, os agentes de primeira linha em monoterapia podem incluir lítio, lamotrigina, quetiapina e quetiapina de liberação prolongada. No que se refere à escolha do estabilizador de humor ideal, o maior potencial de efeitos colaterais relacionados ao lítio vem desestimulando sua prescrição em indivíduos idosos. A eletroconvulsoterapia, embora limitada pela evidência, pode ser uma opção para casos graves/refratários.Associação Brasileira de Psiquiatria2017-12-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-ReviewedRevisado por ParesAvaliado Pelos Paresapplication/pdfhttps://revistardp.org.br/revista/article/view/7010.25118/2236-918X-7-6-3Debates in Psychiatry; Vol. 7 No. 6 (2017); 26-36Debates em Psiquiatria; Vol. 7 Núm. 6 (2017); 26-36Debates em Psiquiatria; v. 7 n. 6 (2017); 26-362763-90372236-918Xreponame:Debates em Psiquiatria (Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABPporhttps://revistardp.org.br/revista/article/view/70/55https://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessAlves, Gilberto SousaSudo, Felipe KenjiBriand, LucasPantel, Johannes2023-06-08T00:53:16Zoai:ojs.emnuvens.com.br:article/70Revistahttps://revistardp.org.br/revista/oaiPUBhttps://revistardp.org.br/revista/oairdp@abp.org.br2763-90372236-918Xopendoar:2023-06-08T00:53:16Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)false
dc.title.none.fl_str_mv Treatment of bipolar disorder in the elderly: a review of the literature
Tratamento do transtorno bipolar no idoso: uma revisão da literatura
title Treatment of bipolar disorder in the elderly: a review of the literature
spellingShingle Treatment of bipolar disorder in the elderly: a review of the literature
Alves, Gilberto Sousa
Bipolar
idoso
tratamento
mania
depressão
envelhecimento
Bipolar
elderly
treatment
mania
depression
aging
title_short Treatment of bipolar disorder in the elderly: a review of the literature
title_full Treatment of bipolar disorder in the elderly: a review of the literature
title_fullStr Treatment of bipolar disorder in the elderly: a review of the literature
title_full_unstemmed Treatment of bipolar disorder in the elderly: a review of the literature
title_sort Treatment of bipolar disorder in the elderly: a review of the literature
author Alves, Gilberto Sousa
author_facet Alves, Gilberto Sousa
Sudo, Felipe Kenji
Briand, Lucas
Pantel, Johannes
author_role author
author2 Sudo, Felipe Kenji
Briand, Lucas
Pantel, Johannes
author2_role author
author
author
dc.contributor.author.fl_str_mv Alves, Gilberto Sousa
Sudo, Felipe Kenji
Briand, Lucas
Pantel, Johannes
dc.subject.por.fl_str_mv Bipolar
idoso
tratamento
mania
depressão
envelhecimento
Bipolar
elderly
treatment
mania
depression
aging
topic Bipolar
idoso
tratamento
mania
depressão
envelhecimento
Bipolar
elderly
treatment
mania
depression
aging
description Bipolar disorder (BAD) is a potentially severe condition characterized by mood shifts and cognitive and functional dysfunction. This article reviews updated evidence on the pharmacological and non-drug interventions for BD in the elderly. Evidence-based guidelines, although useful in promoting rational and effective therapy, are still relatively scarce for BD in aged individuals. Current recommendations for acute mania include the use ofatypical antipsychotics (e.g., risperidone, quetiapine, olanzapine), lithium (with judicious administration), and the choice of valproate as a gold standard therapy. In acute BD depression, first-line monotherapy agents may include lithium, lamotrigine, quetiapine, and extendedrelease quetiapine (XR). Regarding the choice of the ideal mood stabilizer, the greater potential for side effects associated with lithium has discouraged its prescription in elderly individuals. Electroconvulsive therapy, although limited by the evidence available, may be an option for severe/refractory cases.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-Reviewed
Revisado por Pares
Avaliado Pelos Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistardp.org.br/revista/article/view/70
10.25118/2236-918X-7-6-3
url https://revistardp.org.br/revista/article/view/70
identifier_str_mv 10.25118/2236-918X-7-6-3
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistardp.org.br/revista/article/view/70/55
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria
dc.source.none.fl_str_mv Debates in Psychiatry; Vol. 7 No. 6 (2017); 26-36
Debates em Psiquiatria; Vol. 7 Núm. 6 (2017); 26-36
Debates em Psiquiatria; v. 7 n. 6 (2017); 26-36
2763-9037
2236-918X
reponame:Debates em Psiquiatria (Online)
instname:Associação Brasileira de Psiquiatria (ABP)
instacron:ABP
instname_str Associação Brasileira de Psiquiatria (ABP)
instacron_str ABP
institution ABP
reponame_str Debates em Psiquiatria (Online)
collection Debates em Psiquiatria (Online)
repository.name.fl_str_mv Debates em Psiquiatria (Online) - Associação Brasileira de Psiquiatria (ABP)
repository.mail.fl_str_mv rdp@abp.org.br
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