Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9931 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Soares, Milena Botelho PereiraGonçalves, RenataPyrrho, Alexandre dos SantosCosta, Deise de AndradePaiva, Claudia NetoGattass, Cerli Rocha2015-04-08T16:51:46Z2015-04-08T16:51:46Z2003SOARES, M. B. P. et al. Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi. Anais da Academia Brasileira de Ciências, v. 75, n. 2, p. 167-172, 2003.0001-3765https://www.arca.fiocruz.br/handle/icict/9931engAcademia Brasileira de CiênciasBalanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.We have previously demonstrated that inoculation of BALB/c mice with trypomastigotes of CL-14, an avirulent Trypanosoma cruzi clone, prevents the development of parasitemia and mortality after challenge with virulent CL strain. In this report, we investigated the cytokine and antibody profiles induced by inoculation with CL-14 clone. Groups of mice were inoculated with trypomastigotes of CL-14 clone and challenged with infective CL strain. Challenged CL-14-inoculated mice had lower levels of IFN-gamma and higher production of IgG1 antibodies as compared to CL strain-infected mice. Previous inoculation with CL-14 clone partially prevented the suppression of IL-2 production caused by CL strain infection. No significant differences were found regarding IL-4 production by splenocytes from CL-14-inoculated or control groups after challenge with CL-strain. Our results show that protection against acute T. cruzi infection induced by CL-14 inoculation correlates with a balanced T1/T2 cytokine production, a profile likely to be beneficial for the host.Trypanosoma cruziProtectionCytokinesHumoral responseAnticorpos Antiprotozoários/imunologiaCitocinas/biossínteseTrypanosoma cruzi/imunologiaAnimaisCitocinas/sangueImunizaçãoInterferon gama/biossínteseInterferon gama/sangueInterleucina-2/biossínteseCamundongosCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSoares MBP Balanced cytokine-producing....pdfSoares MBP Balanced cytokine-producing....pdfapplication/pdf82880https://www.arca.fiocruz.br/bitstream/icict/9931/2/Soares%20MBP%20Balanced%20cytokine-producing....pdf392ba9561249f774e68cb08021e813eeMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9931/3/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD53TEXTSoares MBP Balanced cytokine-producing....pdf.txtSoares MBP Balanced cytokine-producing....pdf.txtExtracted texttext/plain21749https://www.arca.fiocruz.br/bitstream/icict/9931/4/Soares%20MBP%20Balanced%20cytokine-producing....pdf.txt8accd4beb4047fc253999d75a17325cbMD54icict/99312023-03-15 14:33:17.615oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| title |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| spellingShingle |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi Soares, Milena Botelho Pereira Trypanosoma cruzi Protection Cytokines Humoral response Anticorpos Antiprotozoários/imunologia Citocinas/biossíntese Trypanosoma cruzi/imunologia Animais Citocinas/sangue Imunização Interferon gama/biossíntese Interferon gama/sangue Interleucina-2/biossíntese Camundongos Camundongos Endogâmicos BALB C |
| title_short |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| title_full |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| title_fullStr |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| title_full_unstemmed |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| title_sort |
Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi |
| author |
Soares, Milena Botelho Pereira |
| author_facet |
Soares, Milena Botelho Pereira Gonçalves, Renata Pyrrho, Alexandre dos Santos Costa, Deise de Andrade Paiva, Claudia Neto Gattass, Cerli Rocha |
| author_role |
author |
| author2 |
Gonçalves, Renata Pyrrho, Alexandre dos Santos Costa, Deise de Andrade Paiva, Claudia Neto Gattass, Cerli Rocha |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Soares, Milena Botelho Pereira Gonçalves, Renata Pyrrho, Alexandre dos Santos Costa, Deise de Andrade Paiva, Claudia Neto Gattass, Cerli Rocha |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Protection Cytokines Humoral response |
| topic |
Trypanosoma cruzi Protection Cytokines Humoral response Anticorpos Antiprotozoários/imunologia Citocinas/biossíntese Trypanosoma cruzi/imunologia Animais Citocinas/sangue Imunização Interferon gama/biossíntese Interferon gama/sangue Interleucina-2/biossíntese Camundongos Camundongos Endogâmicos BALB C |
| dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Antiprotozoários/imunologia Citocinas/biossíntese Trypanosoma cruzi/imunologia Animais Citocinas/sangue Imunização Interferon gama/biossíntese Interferon gama/sangue Interleucina-2/biossíntese Camundongos Camundongos Endogâmicos BALB C |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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2003 |
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2003 |
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2015-04-08T16:51:46Z |
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2015-04-08T16:51:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SOARES, M. B. P. et al. Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi. Anais da Academia Brasileira de Ciências, v. 75, n. 2, p. 167-172, 2003. |
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https://www.arca.fiocruz.br/handle/icict/9931 |
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0001-3765 |
| identifier_str_mv |
SOARES, M. B. P. et al. Balanced cytokine-producing pattern in mice immunized with an avirulent Trypanosoma cruzi. Anais da Academia Brasileira de Ciências, v. 75, n. 2, p. 167-172, 2003. 0001-3765 |
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Academia Brasileira de Ciências |
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Academia Brasileira de Ciências |
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