Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42474 |
Resumo: | Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA. |
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Chen, Diana Y.Wolski, DavidAneja, JasneetMatsubara, LyndonRobilotti, BrandonHauck, GarrettSousa, Paulo Sergio Fonseca deSubudhi, SonuFernandes, Carlos AugustoHoogeveen, Ruben C.Kim, Arthur Y.Lewis-Ximenez, LiaLauer, Georg M.2020-07-30T18:48:49Z2020-07-30T18:48:49Z2020CHEN, Diana Y. et al. Hepatitis C virus–specific CD4+ T cell phenotype and function in different infection outcomes. The Journal of Clinical Investigation, v. 130, n. 2, p. 768-773, Feb. 2020.0021-9738https://www.arca.fiocruz.br/handle/icict/4247410.1172/JCI1262771558-8238engAmerican Society for Clinical InvestigationVírus da Hepatite CCD4+ específicoFenótipo de células TInfecçãoHepatitis C virusCD4+ T cell phenotypeInfection outcomesPhenotypeHepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMassachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA / Massachusetts General Hospital and Harvard Medical School, Infectious Disease Division. BostonMassachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit, Boston, Massachusetts, USA..Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.Laboratório Central de Sáud Pública Noel Nutels. Rio de Janeiro, RJ, Brasil.Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.Massachusetts General Hospital and Harvard Medical School, Infectious Disease Division. BostonFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Infecções Virais. Rio de Janeiro, RJ, Brasil.Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA.CD4+ T cell failure is a hallmark of chronic hepatitis C virus (HCV) infection. However, the mechanisms underlying the impairment and loss of virus-specific CD4+ T cells in persisting HCV infection remain unclear. Here we examined HCV-specific CD4+ T cells longitudinally during acute infection with different infection outcomes. We found that HCV-specific CD4+ T cells are characterized by expression of a narrower range of T cell inhibitory receptors compared with CD8+ T cells, with initially high expression levels of PD-1 and CTLA-4 that were associated with negative regulation of proliferation in all patients, irrespective of outcome. In addition, HCV-specific CD4+ T cells were phenotypically similar during early resolving and persistent infection and secreted similar levels of cytokines. However, upon viral control, CD4+ T cells quickly downregulated inhibitory receptors and differentiated into long-lived memory cells. In contrast, persisting viremia continued to drive T cell activation and PD-1 and CTLA-4 expression, and blocked T cell differentiation, until the cells quickly disappeared from the circulation. Our data support an important and physiological role for inhibitory receptor-mediated regulation of CD4+ T cells in early HCV infection, irrespective of outcome, with persistent HCV viremia leading to sustained upregulation of PD-1 and CTLA-4.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42474/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLiaLewisXimenez_PauloSFSouza_etal_IOC_2020.pdfLiaLewisXimenez_PauloSFSouza_etal_IOC_2020.pdfapplication/pdf2298492https://www.arca.fiocruz.br/bitstream/icict/42474/2/LiaLewisXimenez_PauloSFSouza_etal_IOC_2020.pdfd9166d6e1ed027bb63dc678da76bc925MD52TEXTLiaLewisXimenez_PauloSFSouza_etal_IOC_2020.pdf.txtLiaLewisXimenez_PauloSFSouza_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| title |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| spellingShingle |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes Chen, Diana Y. Vírus da Hepatite C CD4+ específico Fenótipo de células T Infecção Hepatitis C virus CD4+ T cell phenotype Infection outcomes Phenotype |
| title_short |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| title_full |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| title_fullStr |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| title_full_unstemmed |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| title_sort |
Hepatitis C virus-specific CD4+ T cell phenotype and function in different infection outcomes |
| author |
Chen, Diana Y. |
| author_facet |
Chen, Diana Y. Wolski, David Aneja, Jasneet Matsubara, Lyndon Robilotti, Brandon Hauck, Garrett Sousa, Paulo Sergio Fonseca de Subudhi, Sonu Fernandes, Carlos Augusto Hoogeveen, Ruben C. Kim, Arthur Y. Lewis-Ximenez, Lia Lauer, Georg M. |
| author_role |
author |
| author2 |
Wolski, David Aneja, Jasneet Matsubara, Lyndon Robilotti, Brandon Hauck, Garrett Sousa, Paulo Sergio Fonseca de Subudhi, Sonu Fernandes, Carlos Augusto Hoogeveen, Ruben C. Kim, Arthur Y. Lewis-Ximenez, Lia Lauer, Georg M. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Chen, Diana Y. Wolski, David Aneja, Jasneet Matsubara, Lyndon Robilotti, Brandon Hauck, Garrett Sousa, Paulo Sergio Fonseca de Subudhi, Sonu Fernandes, Carlos Augusto Hoogeveen, Ruben C. Kim, Arthur Y. Lewis-Ximenez, Lia Lauer, Georg M. |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus da Hepatite C CD4+ específico Fenótipo de células T Infecção |
| topic |
Vírus da Hepatite C CD4+ específico Fenótipo de células T Infecção Hepatitis C virus CD4+ T cell phenotype Infection outcomes Phenotype |
| dc.subject.en.pt_BR.fl_str_mv |
Hepatitis C virus CD4+ T cell phenotype Infection outcomes Phenotype |
| description |
Massachusetts General Hospital and Harvard Medical School, Boston. Gastrointestinal Unit. Boston, Massachusetts, USA. |
| publishDate |
2020 |
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2020-07-30T18:48:49Z |
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2020-07-30T18:48:49Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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CHEN, Diana Y. et al. Hepatitis C virus–specific CD4+ T cell phenotype and function in different infection outcomes. The Journal of Clinical Investigation, v. 130, n. 2, p. 768-773, Feb. 2020. |
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https://www.arca.fiocruz.br/handle/icict/42474 |
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0021-9738 |
| dc.identifier.doi.none.fl_str_mv |
10.1172/JCI126277 |
| dc.identifier.eissn.none.fl_str_mv |
1558-8238 |
| identifier_str_mv |
CHEN, Diana Y. et al. Hepatitis C virus–specific CD4+ T cell phenotype and function in different infection outcomes. The Journal of Clinical Investigation, v. 130, n. 2, p. 768-773, Feb. 2020. 0021-9738 10.1172/JCI126277 1558-8238 |
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eng |
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American Society for Clinical Investigation |
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American Society for Clinical Investigation |
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