Update on the Phylodynamic and Genetic Variability of Marburg Virus.

Detalhes bibliográficos
Autor(a) principal: Scarpa, Fabio
Data de Publicação: 2023
Outros Autores: Bazzani, Liliana, Giovanetti, Marta, Ciccozzi, Alessandra, Benedetti, Francesca, Zella, Davide, Sanna, Daria, Casu, Marco, Borsetti, Alessandra, Cella, Eleonora, Pascarella, Stefano, Maruotti, Antonello, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60710
Resumo: Department of Biomedical Sciences. University of Sassari. Sassari, Italy
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spelling Scarpa, FabioBazzani, LilianaGiovanetti, MartaCiccozzi, AlessandraBenedetti, FrancescaZella, DavideSanna, DariaCasu, MarcoBorsetti, AlessandraCella, EleonoraPascarella, StefanoMaruotti, AntonelloCiccozzi, Massimo2023-10-05T12:33:09Z2023-10-05T12:33:09Z2023SCARPA, Fábio et al. Update on the Phylodynamic and Genetic Variability of Marburg Virus. Viruses, v. 15, n. 8, 1721, 2023. https://dx.doi.org/10.3390/v15081721.1999-4915https://www.arca.fiocruz.br/handle/icict/60710engMPDIUpdate on the Phylodynamic and Genetic Variability of Marburg Virus.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Biomedical Sciences. University of Sassari. Sassari, ItalyDepartment of Science and Technology for Humans and the Environment. Università Campus Bio-Medico di Roma. Rome, ItalyDepartment of Science and Technology for Humans and the Environment. Università Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, BrazilUnit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, ItalyInstitute of Human Virlogy and Global Virusn Network Center. Deparment of Biochemistry and Molecular Biology. University for Maryland School of Medicine. Baltimore, MD, USAInstitute of Human Virlogy and Global Virusn Network Center. Deparment of Biochemistry and Molecular Biology. University for Maryland School of Medicine. Baltimore, MD, USADepartment of Biomedical Sciences. University of Sassari. Sassari, ItalyDepartment of Veterinary Medicine. University of Sassari. Sassari, ItalyNational HIV/AIDS Research Center. National Institute of Health. Rome, ItalyBurnett School of Biomedical Sciences. University of Central Florida. Orlando, FL, USADepartment of Biochemical Sciences “A. Rossi Fanelli”. Sapienza Università di Roma. Rome, ItalyDepartment GEPLI. Libera Università Maria Ss Assunta. Rome, ItalyUnit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, ItalyThe COVID-19 pandemic has not only strained healthcare systems in Africa but has also intensified the impact of emerging and re-emerging diseases. Specifically in Equatorial Guinea, mirroring the situation in other African countries, unique zoonotic outbreaks have occurred during this challenging period. One notable resurgence is Marburg virus disease (MVD), which has further burdened the already fragile healthcare system. The re-emergence of the Marburg virus amid the COVID-19 pandemic is believed to stem from a probable zoonotic spill-over, although the precise transmission routes remain uncertain. Given the gravity of the situation, addressing the existing challenges is paramount. Though the genome sequences from the current outbreak were not available for this study, we analyzed all the available whole genome sequences of this re-emerging pathogen to advocate for a shift towards active surveillance. This is essential to ensure the successful containment of any potential Marburg virus outbreak in Equatorial Guinea and the wider African context. This study, which presents an update on the phylodynamics and the genetic variability of MARV, further confirmed the existence of at least two distinct patterns of viral spread. One pattern demonstrates a slower but continuous and recurring virus circulation, while the other exhibits a faster yet limited and episodic spread. These results highlight the critical need to strengthen genomic surveillance in the region to effectively curb the pathogen’s dissemination. Moreover, the study emphasizes the importance of prompt alert management, comprehensive case investigation and analysis, contact tracing, and active case searching. These steps are vital to support the healthcare system’s response to this emerging health crisis. By implementing these strategies, we can better arm ourselves against the challenges posed by the resurgence of the Marburg virus and other infectious diseases.MARVgenetic variabilitygenomic surveillancephylodynamicsAfricainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60710/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALUpdate on the Phylodynamic and Genetic Variability of Marburg Virus.pdfUpdate on the Phylodynamic and Genetic Variability of Marburg Virus.pdfapplication/pdf1552185https://www.arca.fiocruz.br/bitstream/icict/60710/2/Update%20on%20the%20Phylodynamic%20and%20Genetic%20Variability%20of%20Marburg%20Virus.pdf9e5b53222a6adb3a0da255111f1929f0MD52icict/607102023-10-05 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dc.title.en_US.fl_str_mv Update on the Phylodynamic and Genetic Variability of Marburg Virus.
title Update on the Phylodynamic and Genetic Variability of Marburg Virus.
spellingShingle Update on the Phylodynamic and Genetic Variability of Marburg Virus.
Scarpa, Fabio
MARV
genetic variability
genomic surveillance
phylodynamics
Africa
title_short Update on the Phylodynamic and Genetic Variability of Marburg Virus.
title_full Update on the Phylodynamic and Genetic Variability of Marburg Virus.
title_fullStr Update on the Phylodynamic and Genetic Variability of Marburg Virus.
title_full_unstemmed Update on the Phylodynamic and Genetic Variability of Marburg Virus.
title_sort Update on the Phylodynamic and Genetic Variability of Marburg Virus.
author Scarpa, Fabio
author_facet Scarpa, Fabio
Bazzani, Liliana
Giovanetti, Marta
Ciccozzi, Alessandra
Benedetti, Francesca
Zella, Davide
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Cella, Eleonora
Pascarella, Stefano
Maruotti, Antonello
Ciccozzi, Massimo
author_role author
author2 Bazzani, Liliana
Giovanetti, Marta
Ciccozzi, Alessandra
Benedetti, Francesca
Zella, Davide
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Cella, Eleonora
Pascarella, Stefano
Maruotti, Antonello
Ciccozzi, Massimo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Scarpa, Fabio
Bazzani, Liliana
Giovanetti, Marta
Ciccozzi, Alessandra
Benedetti, Francesca
Zella, Davide
Sanna, Daria
Casu, Marco
Borsetti, Alessandra
Cella, Eleonora
Pascarella, Stefano
Maruotti, Antonello
Ciccozzi, Massimo
dc.subject.en.en_US.fl_str_mv MARV
genetic variability
genomic surveillance
phylodynamics
Africa
topic MARV
genetic variability
genomic surveillance
phylodynamics
Africa
description Department of Biomedical Sciences. University of Sassari. Sassari, Italy
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-10-05T12:33:09Z
dc.date.available.fl_str_mv 2023-10-05T12:33:09Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCARPA, Fábio et al. Update on the Phylodynamic and Genetic Variability of Marburg Virus. Viruses, v. 15, n. 8, 1721, 2023. https://dx.doi.org/10.3390/v15081721.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60710
dc.identifier.issn.en_US.fl_str_mv 1999-4915
identifier_str_mv SCARPA, Fábio et al. Update on the Phylodynamic and Genetic Variability of Marburg Virus. Viruses, v. 15, n. 8, 1721, 2023. https://dx.doi.org/10.3390/v15081721.
1999-4915
url https://www.arca.fiocruz.br/handle/icict/60710
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MPDI
publisher.none.fl_str_mv MPDI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60710/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60710/2/Update%20on%20the%20Phylodynamic%20and%20Genetic%20Variability%20of%20Marburg%20Virus.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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