Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)

Duarte, Giselle da Silva; Jones, Alexandra D.; Cavalcanti, Luciano Pamplona de Goes; Rêgo, Moacyr Jesus Barreto de Melo; Ribeiro, Guilherme S.; Boyton, Rosemary J.; Pereira, Dhelio Batista; Croda, Júlio Henrique Rosa; Costa, Fabio Trindade Maranhão; Duarte, Angela Pinto; Consolaro, Marcia Edilaine Lopes; Stabeli, Rodrigo Guerino; Negrão, Fábio Juliano; Modena, Jose Luiz Proenca; Salcedo, Juan Miguel Villalobos; Pinheiro, Geraldo da Rocha Castelar; Albuquerque, Amanda Pinheiro de Barros; Barreto, Francisca Kalline de Almeida; Moreira, José; Ferrari, Idalina Cristina; Évora, Patricia Martinez; Silva, Vânia Ramos Sela da; Lacerda, Marcus Vinicius Guimarães; Altmann, Daniel M.; Siqueira, André M.

Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)

Detalhes bibliográficos
Autor(a) principal:	Duarte, Giselle da Silva
Data de Publicação:	2023
Outros Autores:	Jones, Alexandra D., Cavalcanti, Luciano Pamplona de Goes, Rêgo, Moacyr Jesus Barreto de Melo, Ribeiro, Guilherme S., Boyton, Rosemary J., Pereira, Dhelio Batista, Croda, Júlio Henrique Rosa, Costa, Fabio Trindade Maranhão, Duarte, Angela Pinto, Consolaro, Marcia Edilaine Lopes, Stabeli, Rodrigo Guerino, Negrão, Fábio Juliano, Modena, Jose Luiz Proenca, Salcedo, Juan Miguel Villalobos, Pinheiro, Geraldo da Rocha Castelar, Albuquerque, Amanda Pinheiro de Barros, Barreto, Francisca Kalline de Almeida, Moreira, José, Ferrari, Idalina Cristina, Évora, Patricia Martinez, Silva, Vânia Ramos Sela da, Lacerda, Marcus Vinicius Guimarães, Altmann, Daniel M., Siqueira, André M.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/61064
Resumo:	For the investigators of the REPLICK Network: Thyago Henrique Pereira dos Santos, Fernanda Montenegro de Carvalho Araujo; Luis Arthur Brazil Gadelha Farias, Lara Moreira Teles de Vasconcelos; Brena Ferreira dos Santos; Shamyr Sulyvan de Castro; Marina Carvalho Arruda Barreto; Ileana Pitombeira Gomes; Jobson Lopes de Oliveira; Thayanne Vitoria Nunes Pinheiro; Samara Bezerra Guedes das Neves; Carla Cristiana Judice; Gabriela Fabiano de Souza; Matheus Cavalheiro Martini; Deusilene Souza Vieira Dall’Acqua; Marcela Macedo de Oliveira; Eduardo Garbin; Alexia Martines; Maira Galdino da Rocha Pitta; Luiz Demarchi; Caroline Santos Soares.

Metadados do item

id	CRUZ_0ebb04cddd635c341a74f91fae0912f0
oai_identifier_str	oai:www.arca.fiocruz.br:icict/61064
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Duarte, Giselle da SilvaJones, Alexandra D.Cavalcanti, Luciano Pamplona de GoesRêgo, Moacyr Jesus Barreto de MeloRibeiro, Guilherme S.Boyton, Rosemary J.Pereira, Dhelio BatistaCroda, Júlio Henrique RosaCosta, Fabio Trindade MaranhãoDuarte, Angela PintoConsolaro, Marcia Edilaine LopesStabeli, Rodrigo GuerinoNegrão, Fábio JulianoModena, Jose Luiz ProencaSalcedo, Juan Miguel VillalobosPinheiro, Geraldo da Rocha CastelarAlbuquerque, Amanda Pinheiro de BarrosBarreto, Francisca Kalline de AlmeidaMoreira, JoséFerrari, Idalina CristinaÉvora, Patricia MartinezSilva, Vânia Ramos Sela daLacerda, Marcus Vinicius GuimarãesAltmann, Daniel M.Siqueira, André M.2023-11-07T15:27:09Z2023-11-07T15:27:09Z2023DUARTE, Giselle da Silva et al. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases, v. 23, n. 499, p. 1-12, 2023.1471-2334https://www.arca.fiocruz.br/handle/icict/6106410.1186/s12879-023-08292-yFor the investigators of the REPLICK Network: Thyago Henrique Pereira dos Santos, Fernanda Montenegro de Carvalho Araujo; Luis Arthur Brazil Gadelha Farias, Lara Moreira Teles de Vasconcelos; Brena Ferreira dos Santos; Shamyr Sulyvan de Castro; Marina Carvalho Arruda Barreto; Ileana Pitombeira Gomes; Jobson Lopes de Oliveira; Thayanne Vitoria Nunes Pinheiro; Samara Bezerra Guedes das Neves; Carla Cristiana Judice; Gabriela Fabiano de Souza; Matheus Cavalheiro Martini; Deusilene Souza Vieira Dall’Acqua; Marcela Macedo de Oliveira; Eduardo Garbin; Alexia Martines; Maira Galdino da Rocha Pitta; Luiz Demarchi; Caroline Santos Soares.Departamento de Ciência e Tecnologia da Ministério da Saúde do Brasil. Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP).Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.University of California. Berkeley, USA.Universidade Federal do Ceara. Fortaleza, CE, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Imperial College of London, London, UK.Centro de Pesquisa em Medicina Tropical de Rondônia. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Mato Grosso Do Sul. Campo Grande, MS, Brasil.Universidade Estadual de Campinas. Campinas, Brasil.Hospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brasil.Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil.Fundação Oswaldo Cruz. Plataforma de Medicina Translacional. São Paulo, SP, Brasil.Universidade Federal da Grande Dourados. Dourados, MS, Brasil.Universidade Estadual de Campinas. Campinas, Brasil.Fundação Oswaldo Cruz. São Paulo, SP, Brasil.Universidade Estadual do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal de Pernambuco. Departamento de Bioquímica. Recife, PE, Brasil.Universidade Federal do Ceara. Fortaleza, CE, Brasil.Universidade Federal da Grande Dourados. Dourados, MS, Brasil.Fundação Oswaldo Cruz. Plataforma de Medicina Translacional. São Paulo, SP, Brasil.Universidade Estadual de Maringá. Departamento de Análises Clínicas e Biomedicina. Maringá, PR, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Imperial College of London, London, UK.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Background: Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although this classification has been designed to help guide therapeutic decisions, it does not encompass the complexity of the clinical expression of the disease and does not assist in the evaluation of the prognosis of severity nor chronic disease. Thus, the current challenge is to identify and diagnose musculoskeletal disorders and to provide the optimal treatment in order to prevent perpetuation or progression to a potentially destructive disease course. Methods: The study is the first product of the Clinical and Applied Research Network in Chikungunya (REPLICK). This is a prospective, outpatient department-based, multicenter cohort study in Brazil. Four work packages were defined: i. Clinical research; ii) Translational Science – comprising immunology and virology streams; iii) Epidemiology and Economics; iv) Therapeutic Response and clinical trials design. Scheduled appointments on days 21 (D21) ± 7 after enrollment, D90 ± 15, D120 ± 30, D180 ± 30; D360 ± 30; D720 ± 60, and D1080 ± 60 days. On these visits a panel of blood tests are collected in addition to the clinical report forms to obtain data on socio-demographic, medical history, physical examination and questionnaires devoted to the evaluation of musculoskeletal manifestations and overall health are performed. Participants are asked to consent for their specimens to be maintained in a biobank. Aliquots of blood, serum, saliva, PAXgene, and when clinically indicated to be examined, synovial fluid, are stored at -80° C. The study protocol was submitted and approved to the National IRB and local IRB at each study site. Discussion Standardized and harmonized patient cohorts are needed to provide better estimates of chronic arthralgia development, the clinical spectra of acute and chronic disease and investigation of associated risk factors. This study is the largest evaluation of the long-term sequelae of individuals infected with CHIKV in the Brazilian population focusing on musculoskeletal manifestations, mental health, quality of life, and chronic pain. This information will both define disease burden and costs associated with CHIKV infection, and better inform therapeutic guidelines.engBMCChikungunyaCoorteBrasilManifestações reumáticasChikungunyaCohortBrazilRheumatic manifestationsChikungunyaCoorteBrasilDoenças reumáticasMulticenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/61064/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDuarte, Giselle da Silva - Multicenter study of the natural history and therapeutic responses of patients.pdfDuarte, Giselle da Silva - Multicenter study of the natural history and therapeutic responses of patients.pdfapplication/pdf1771137https://www.arca.fiocruz.br/bitstream/icict/61064/2/Duarte%2c%20Giselle%20da%20Silva%20-%20%20Multicenter%20study%20of%20the%20natural%20history%20and%20therapeutic%20responses%20of%20patients.pdfa8cc25767d95440a09580b47713eab0eMD52icict/610642023-11-07 13:22:41.995oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-11-07T16:22:41Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.en_US.fl_str_mv	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
title	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
spellingShingle	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network) Duarte, Giselle da Silva Chikungunya Coorte Brasil Manifestações reumáticas Chikungunya Cohort Brazil Rheumatic manifestations Chikungunya Coorte Brasil Doenças reumáticas
title_short	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
title_full	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
title_fullStr	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
title_full_unstemmed	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
title_sort	Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
author	Duarte, Giselle da Silva
author_facet	Duarte, Giselle da Silva Jones, Alexandra D. Cavalcanti, Luciano Pamplona de Goes Rêgo, Moacyr Jesus Barreto de Melo Ribeiro, Guilherme S. Boyton, Rosemary J. Pereira, Dhelio Batista Croda, Júlio Henrique Rosa Costa, Fabio Trindade Maranhão Duarte, Angela Pinto Consolaro, Marcia Edilaine Lopes Stabeli, Rodrigo Guerino Negrão, Fábio Juliano Modena, Jose Luiz Proenca Salcedo, Juan Miguel Villalobos Pinheiro, Geraldo da Rocha Castelar Albuquerque, Amanda Pinheiro de Barros Barreto, Francisca Kalline de Almeida Moreira, José Ferrari, Idalina Cristina Évora, Patricia Martinez Silva, Vânia Ramos Sela da Lacerda, Marcus Vinicius Guimarães Altmann, Daniel M. Siqueira, André M.
author_role	author
author2	Jones, Alexandra D. Cavalcanti, Luciano Pamplona de Goes Rêgo, Moacyr Jesus Barreto de Melo Ribeiro, Guilherme S. Boyton, Rosemary J. Pereira, Dhelio Batista Croda, Júlio Henrique Rosa Costa, Fabio Trindade Maranhão Duarte, Angela Pinto Consolaro, Marcia Edilaine Lopes Stabeli, Rodrigo Guerino Negrão, Fábio Juliano Modena, Jose Luiz Proenca Salcedo, Juan Miguel Villalobos Pinheiro, Geraldo da Rocha Castelar Albuquerque, Amanda Pinheiro de Barros Barreto, Francisca Kalline de Almeida Moreira, José Ferrari, Idalina Cristina Évora, Patricia Martinez Silva, Vânia Ramos Sela da Lacerda, Marcus Vinicius Guimarães Altmann, Daniel M. Siqueira, André M.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Duarte, Giselle da Silva Jones, Alexandra D. Cavalcanti, Luciano Pamplona de Goes Rêgo, Moacyr Jesus Barreto de Melo Ribeiro, Guilherme S. Boyton, Rosemary J. Pereira, Dhelio Batista Croda, Júlio Henrique Rosa Costa, Fabio Trindade Maranhão Duarte, Angela Pinto Consolaro, Marcia Edilaine Lopes Stabeli, Rodrigo Guerino Negrão, Fábio Juliano Modena, Jose Luiz Proenca Salcedo, Juan Miguel Villalobos Pinheiro, Geraldo da Rocha Castelar Albuquerque, Amanda Pinheiro de Barros Barreto, Francisca Kalline de Almeida Moreira, José Ferrari, Idalina Cristina Évora, Patricia Martinez Silva, Vânia Ramos Sela da Lacerda, Marcus Vinicius Guimarães Altmann, Daniel M. Siqueira, André M.
dc.subject.other.en_US.fl_str_mv	Chikungunya Coorte Brasil Manifestações reumáticas
topic	Chikungunya Coorte Brasil Manifestações reumáticas Chikungunya Cohort Brazil Rheumatic manifestations Chikungunya Coorte Brasil Doenças reumáticas
dc.subject.en.en_US.fl_str_mv	Chikungunya Cohort Brazil Rheumatic manifestations
dc.subject.decs.en_US.fl_str_mv	Chikungunya Coorte Brasil Doenças reumáticas
description	For the investigators of the REPLICK Network: Thyago Henrique Pereira dos Santos, Fernanda Montenegro de Carvalho Araujo; Luis Arthur Brazil Gadelha Farias, Lara Moreira Teles de Vasconcelos; Brena Ferreira dos Santos; Shamyr Sulyvan de Castro; Marina Carvalho Arruda Barreto; Ileana Pitombeira Gomes; Jobson Lopes de Oliveira; Thayanne Vitoria Nunes Pinheiro; Samara Bezerra Guedes das Neves; Carla Cristiana Judice; Gabriela Fabiano de Souza; Matheus Cavalheiro Martini; Deusilene Souza Vieira Dall’Acqua; Marcela Macedo de Oliveira; Eduardo Garbin; Alexia Martines; Maira Galdino da Rocha Pitta; Luiz Demarchi; Caroline Santos Soares.
publishDate	2023
dc.date.accessioned.fl_str_mv	2023-11-07T15:27:09Z
dc.date.available.fl_str_mv	2023-11-07T15:27:09Z
dc.date.issued.fl_str_mv	2023
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	DUARTE, Giselle da Silva et al. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases, v. 23, n. 499, p. 1-12, 2023.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/61064
dc.identifier.issn.en_US.fl_str_mv	1471-2334
dc.identifier.doi.none.fl_str_mv	10.1186/s12879-023-08292-y
identifier_str_mv	DUARTE, Giselle da Silva et al. Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network). BMC Infectious Diseases, v. 23, n. 499, p. 1-12, 2023. 1471-2334 10.1186/s12879-023-08292-y
url	https://www.arca.fiocruz.br/handle/icict/61064
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BMC
publisher.none.fl_str_mv	BMC
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/61064/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/61064/2/Duarte%2c%20Giselle%20da%20Silva%20-%20%20Multicenter%20study%20of%20the%20natural%20history%20and%20therapeutic%20responses%20of%20patients.pdf
bitstream.checksum.fl_str_mv	5a560609d32a3863062d77ff32785d58 a8cc25767d95440a09580b47713eab0e
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations: a study protocol from the clinical and applied research in Chikungunya (REPLICK network)

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