Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism

Detalhes bibliográficos
Autor(a) principal: Yahouédéhou, Sètondji Cocou Modeste Alexandre
Data de Publicação: 2018
Outros Autores: Adorno, Elisângela Vitória, Guarda, Caroline Conceição da, Ndidi, Uche Samuel, Carvalho, Suellen Pinheiro, Santiago, Rayra Pereira, Aleluia, Milena Magalhães, Oliveira, Rodrigo Mota de, Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30640
Resumo: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.
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spelling Yahouédéhou, Sètondji Cocou Modeste AlexandreAdorno, Elisângela VitóriaGuarda, Caroline Conceição daNdidi, Uche SamuelCarvalho, Suellen PinheiroSantiago, Rayra PereiraAleluia, Milena MagalhãesOliveira, Rodrigo Mota deGonçalves, Marilda de Souza2018-12-17T17:49:24Z2018-12-17T17:49:24Z2018YAHOUÉDÉHOU, S. C. M. A. et al. Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism. Pharmacogenomics Journal, sep. 2018.1470-269Xhttps://www.arca.fiocruz.br/handle/icict/3064010.1038/s41397-018-0045-1engSpringer NatureDoença falciformeHidroxiureiaFatores socioeconômicosTratamentoMetabolismoAnemia, Sickle CellHydroxyureaSocioeconomic FactorsTherapyMetabolismHydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.Hydroxyurea (HU) was approved to be used in the treatment of sickle cell disease (SCD) because of its anti-sickling potential. However, there is variability in HU response among SCD patients and this can be due to physiological, socioeconomic, environmental, metabolic and/or genetic factors. The present review focuses on the latter two. Three quantitative trait loci, HBG2, BCL11A and HMIP, have been suggested as important markers for HU response. Other genes (ASS1, KLF10, HAO2, MAP3K5, PDE7B, TOX, NOS1, NOS2A, FLT1, ARG1, ARG2, UGT1A1, OR51B5/6, SIN3A, SALL2, SAR1A, UTB, OCTN1, CYP2C9, AQP9, MPO, CYP2E1, and GSTT1) have also been considered. Studies implicate catalase, urease, horseradish peroxidase and enzymes of CYP450 family in HU metabolism. However, little is known about these enzymes. Therefore, further studies are needed to elucidate the metabolic pathway of HU, which will facilitate pharmacogenomic studies and help in identification of candidate genes for predicting HU response.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30640/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYahouedehou SCMA Hydroxyurea in the....pdfYahouedehou SCMA Hydroxyurea in the....pdfapplication/pdf590783https://www.arca.fiocruz.br/bitstream/icict/30640/2/Yahouedehou%20SCMA%20Hydroxyurea%20in%20the....pdfbbd5c090cc7d875c0687cd3b8a0c0e4cMD52TEXTYahouedehou SCMA Hydroxyurea in the....pdf.txtYahouedehou SCMA Hydroxyurea in the....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
title Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
spellingShingle Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
Yahouédéhou, Sètondji Cocou Modeste Alexandre
Doença falciforme
Hidroxiureia
Fatores socioeconômicos
Tratamento
Metabolismo
Anemia, Sickle Cell
Hydroxyurea
Socioeconomic Factors
Therapy
Metabolism
title_short Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
title_full Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
title_fullStr Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
title_full_unstemmed Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
title_sort Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
author Yahouédéhou, Sètondji Cocou Modeste Alexandre
author_facet Yahouédéhou, Sètondji Cocou Modeste Alexandre
Adorno, Elisângela Vitória
Guarda, Caroline Conceição da
Ndidi, Uche Samuel
Carvalho, Suellen Pinheiro
Santiago, Rayra Pereira
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota de
Gonçalves, Marilda de Souza
author_role author
author2 Adorno, Elisângela Vitória
Guarda, Caroline Conceição da
Ndidi, Uche Samuel
Carvalho, Suellen Pinheiro
Santiago, Rayra Pereira
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota de
Gonçalves, Marilda de Souza
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Yahouédéhou, Sètondji Cocou Modeste Alexandre
Adorno, Elisângela Vitória
Guarda, Caroline Conceição da
Ndidi, Uche Samuel
Carvalho, Suellen Pinheiro
Santiago, Rayra Pereira
Aleluia, Milena Magalhães
Oliveira, Rodrigo Mota de
Gonçalves, Marilda de Souza
dc.subject.other.pt_BR.fl_str_mv Doença falciforme
Hidroxiureia
Fatores socioeconômicos
Tratamento
Metabolismo
topic Doença falciforme
Hidroxiureia
Fatores socioeconômicos
Tratamento
Metabolismo
Anemia, Sickle Cell
Hydroxyurea
Socioeconomic Factors
Therapy
Metabolism
dc.subject.en.pt_BR.fl_str_mv Anemia, Sickle Cell
Hydroxyurea
Socioeconomic Factors
Therapy
Metabolism
description Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Investigação em Genética e Hematologia Translacional. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Pesquisa em Anemia. Departamento de Análises Clínicas. Salvador, BA, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-17T17:49:24Z
dc.date.available.fl_str_mv 2018-12-17T17:49:24Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv YAHOUÉDÉHOU, S. C. M. A. et al. Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism. Pharmacogenomics Journal, sep. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30640
dc.identifier.issn.pt_BR.fl_str_mv 1470-269X
dc.identifier.doi.none.fl_str_mv 10.1038/s41397-018-0045-1
identifier_str_mv YAHOUÉDÉHOU, S. C. M. A. et al. Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism. Pharmacogenomics Journal, sep. 2018.
1470-269X
10.1038/s41397-018-0045-1
url https://www.arca.fiocruz.br/handle/icict/30640
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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