Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31138 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. |
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Miranda, Luisa Helena Monteiro deSilva, Jéssica NunesGremião, Isabella Dib FerreiraMenezes, Rodrigo CaldasAlmeida-Paes, RodrigoReis, Érica Guerino dosOliveira, Raquel de Vasconcellos Carvalhaes deAraujo, Danuza Salles do AmaralFerreiro, LaertePereira, Sandro Antonio2019-01-18T13:02:07Z2019-01-18T13:02:07Z2018MIRANDA, Luisa Helena Monteiro de et al. Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response. Journal of Fungi, v. 4, n. 92, p. 1-11, Aug. 2018.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/3113810.3390/jof40300922309-608XengMDPIMonitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária. Laboratório de Micologia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Fiocruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária. Laboratório de Micologia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen.SporotrichosisCatFungal burdenItraconazolePotassium iodideinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/31138/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Miranda_Luisa_etal_INI_2018.pdfve_Miranda_Luisa_etal_INI_2018.pdfapplication/pdf269386https://www.arca.fiocruz.br/bitstream/icict/31138/2/ve_Miranda_Luisa_etal_INI_2018.pdf106af8f928585b9bef35735da1bf9184MD52TEXTve_Miranda_Luisa_etal_INI_2018.pdf.txtve_Miranda_Luisa_etal_INI_2018.pdf.txtExtracted texttext/plain37824https://www.arca.fiocruz.br/bitstream/icict/31138/3/ve_Miranda_Luisa_etal_INI_2018.pdf.txt8efed859525c791c83af794b9733c0f8MD53icict/311382019-01-19 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dc.title.pt_BR.fl_str_mv |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
spellingShingle |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response Miranda, Luisa Helena Monteiro de Sporotrichosis Cat Fungal burden Itraconazole Potassium iodide |
title_short |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_full |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_fullStr |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_full_unstemmed |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
title_sort |
Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response |
author |
Miranda, Luisa Helena Monteiro de |
author_facet |
Miranda, Luisa Helena Monteiro de Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo Reis, Érica Guerino dos Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio |
author_role |
author |
author2 |
Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo Reis, Érica Guerino dos Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Miranda, Luisa Helena Monteiro de Silva, Jéssica Nunes Gremião, Isabella Dib Ferreira Menezes, Rodrigo Caldas Almeida-Paes, Rodrigo Reis, Érica Guerino dos Oliveira, Raquel de Vasconcellos Carvalhaes de Araujo, Danuza Salles do Amaral Ferreiro, Laerte Pereira, Sandro Antonio |
dc.subject.en.pt_BR.fl_str_mv |
Sporotrichosis Cat Fungal burden Itraconazole Potassium iodide |
topic |
Sporotrichosis Cat Fungal burden Itraconazole Potassium iodide |
description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-01-18T13:02:07Z |
dc.date.available.fl_str_mv |
2019-01-18T13:02:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MIRANDA, Luisa Helena Monteiro de et al. Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response. Journal of Fungi, v. 4, n. 92, p. 1-11, Aug. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31138 |
dc.identifier.issn.pt_BR.fl_str_mv |
2309-608X |
dc.identifier.doi.none.fl_str_mv |
10.3390/jof4030092 |
dc.identifier.eissn.none.fl_str_mv |
2309-608X |
identifier_str_mv |
MIRANDA, Luisa Helena Monteiro de et al. Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response. Journal of Fungi, v. 4, n. 92, p. 1-11, Aug. 2018. 2309-608X 10.3390/jof4030092 |
url |
https://www.arca.fiocruz.br/handle/icict/31138 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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MDPI |
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MDPI |
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