Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response

Detalhes bibliográficos
Autor(a) principal: Miranda, Luisa Helena Monteiro de
Data de Publicação: 2018
Outros Autores: Silva, Jéssica Nunes, Gremião, Isabella Dib Ferreira, Menezes, Rodrigo Caldas, Almeida-Paes, Rodrigo, Reis, Érica Guerino dos, Oliveira, Raquel de Vasconcellos Carvalhaes de, Araujo, Danuza Salles do Amaral, Ferreiro, Laerte, Pereira, Sandro Antonio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31138
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.
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spelling Miranda, Luisa Helena Monteiro deSilva, Jéssica NunesGremião, Isabella Dib FerreiraMenezes, Rodrigo CaldasAlmeida-Paes, RodrigoReis, Érica Guerino dosOliveira, Raquel de Vasconcellos Carvalhaes deAraujo, Danuza Salles do AmaralFerreiro, LaertePereira, Sandro Antonio2019-01-18T13:02:07Z2019-01-18T13:02:07Z2018MIRANDA, Luisa Helena Monteiro de et al. Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response. Journal of Fungi, v. 4, n. 92, p. 1-11, Aug. 2018.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/3113810.3390/jof40300922309-608XengMDPIMonitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária. Laboratório de Micologia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clínica. Fiocruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária. Laboratório de Micologia. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Skin lesions in feline sporotrichosis usually present a high fungal burden, making cats an important source of infection. This study evaluated the fungal burden and isolation in skin lesions of feline sporotrichosis during treatment with itraconazole (ITZ), combined with or without potassium iodide (KI). Treatment-naïve cats with culture-confirmed sporotrichosis and presenting skin ulcers were treated for up to 40 weeks with oral ITZ alone (n = 74) or combined with KI (n = 56). These cats were submitted to monthly sampling of the same lesion for mycological culture and cytopathology until healing of lesion or up to twelve weeks. The fungal burden was expressed as the mean yeast cell count in three microscopic fields from imprint smears. The fungal burden before treatment was significantly higher in cats in which the lesion persisted and in cases of treatment failure when using ITZ alone. After twelve weeks, the median fungal burden decreased to zero in both treatment protocols, suggesting a potential decrease in the risk of transmission of Sporothrix spp. from cats. These findings encourage the early treatment of feline sporotrichosis as a control measure. Moreover, the fungal burden in feline sporotrichosis lesions can be a prognostic indicator and a parameter for choosing appropriate therapeutic regimen.SporotrichosisCatFungal burdenItraconazolePotassium iodideinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/31138/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Miranda_Luisa_etal_INI_2018.pdfve_Miranda_Luisa_etal_INI_2018.pdfapplication/pdf269386https://www.arca.fiocruz.br/bitstream/icict/31138/2/ve_Miranda_Luisa_etal_INI_2018.pdf106af8f928585b9bef35735da1bf9184MD52TEXTve_Miranda_Luisa_etal_INI_2018.pdf.txtve_Miranda_Luisa_etal_INI_2018.pdf.txtExtracted texttext/plain37824https://www.arca.fiocruz.br/bitstream/icict/31138/3/ve_Miranda_Luisa_etal_INI_2018.pdf.txt8efed859525c791c83af794b9733c0f8MD53icict/311382019-01-19 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dc.title.pt_BR.fl_str_mv Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
title Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
spellingShingle Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
Miranda, Luisa Helena Monteiro de
Sporotrichosis
Cat
Fungal burden
Itraconazole
Potassium iodide
title_short Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
title_full Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
title_fullStr Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
title_full_unstemmed Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
title_sort Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response
author Miranda, Luisa Helena Monteiro de
author_facet Miranda, Luisa Helena Monteiro de
Silva, Jéssica Nunes
Gremião, Isabella Dib Ferreira
Menezes, Rodrigo Caldas
Almeida-Paes, Rodrigo
Reis, Érica Guerino dos
Oliveira, Raquel de Vasconcellos Carvalhaes de
Araujo, Danuza Salles do Amaral
Ferreiro, Laerte
Pereira, Sandro Antonio
author_role author
author2 Silva, Jéssica Nunes
Gremião, Isabella Dib Ferreira
Menezes, Rodrigo Caldas
Almeida-Paes, Rodrigo
Reis, Érica Guerino dos
Oliveira, Raquel de Vasconcellos Carvalhaes de
Araujo, Danuza Salles do Amaral
Ferreiro, Laerte
Pereira, Sandro Antonio
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Luisa Helena Monteiro de
Silva, Jéssica Nunes
Gremião, Isabella Dib Ferreira
Menezes, Rodrigo Caldas
Almeida-Paes, Rodrigo
Reis, Érica Guerino dos
Oliveira, Raquel de Vasconcellos Carvalhaes de
Araujo, Danuza Salles do Amaral
Ferreiro, Laerte
Pereira, Sandro Antonio
dc.subject.en.pt_BR.fl_str_mv Sporotrichosis
Cat
Fungal burden
Itraconazole
Potassium iodide
topic Sporotrichosis
Cat
Fungal burden
Itraconazole
Potassium iodide
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-01-18T13:02:07Z
dc.date.available.fl_str_mv 2019-01-18T13:02:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIRANDA, Luisa Helena Monteiro de et al. Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response. Journal of Fungi, v. 4, n. 92, p. 1-11, Aug. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31138
dc.identifier.issn.pt_BR.fl_str_mv 2309-608X
dc.identifier.doi.none.fl_str_mv 10.3390/jof4030092
dc.identifier.eissn.none.fl_str_mv 2309-608X
identifier_str_mv MIRANDA, Luisa Helena Monteiro de et al. Monitoring fungal burden and viability of Sporothrix spp. in skin lesions of cats for predicting antifungal treatment response. Journal of Fungi, v. 4, n. 92, p. 1-11, Aug. 2018.
2309-608X
10.3390/jof4030092
url https://www.arca.fiocruz.br/handle/icict/31138
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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