Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens

Detalhes bibliográficos
Autor(a) principal: Mascarenhas, Rita Elizabeth Moreira
Data de Publicação: 2006
Outros Autores: Brodskyn, Claudia Ida, Barbosa, Geisa, Clarêncio, Jorge, Andrade Filho, Antonio de Souza, Figueiroa, Frederico, Castro Filho, Bernardo Galvão, Grassi, Maria Fernanda Rios
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8125
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
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spelling Mascarenhas, Rita Elizabeth MoreiraBrodskyn, Claudia IdaBarbosa, GeisaClarêncio, JorgeAndrade Filho, Antonio de SouzaFigueiroa, FredericoCastro Filho, Bernardo GalvãoGrassi, Maria Fernanda Rios2014-08-04T18:42:15Z2014-08-04T18:42:15Z2006MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006.1556-6811https://www.arca.fiocruz.br/handle/icict/812510.1128/CVI.13.5.547–552.2006engAmerican Society for MicrobiologyPeripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, BrasilNeurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilNeurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilEvidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to chronic immunosuppression and a greater susceptibility to infectious diseases. Spontaneous in vitro proliferation of peripheral blood mononuclear cells (PBMC) is an important immunological feature of HTLV-1-infected individuals. However, the association between spontaneous proliferation and immunosuppression is not clear. In this study, we evaluated the cellular immune responses of PBMC from 58 asymptomatic HTLV-1-infected individuals with PBMC showing or not showing spontaneous proliferation. Individuals with PBMC that spontaneously proliferated had increased proportions of CD4 T cells expressing CD45RO and dramatically reduced responses to recall antigens. In addition, frequencies of positive responses to recall antigens were also decreased in HTLV-infected individuals without spontaneous proliferation of PBMC. There was a polyclonal expansion of multiple T-cell receptor V families of CD4 T lymphocytes in patients with spontaneous proliferation. We observed that HTLV-1 induced an immunosuppression characterized by a decrease in the stimulation index to a recall antigen, even in individuals who did not present spontaneous proliferation. On the other hand, only patients with PBMC presenting spontaneous proliferation showed polyclonal activation and increased proportion of CD4 T cells expressing CD45RO.Antígenos/imunologiaInfecções por HTLV-I/imunologiaVírus 1 Linfotrópico T Humano/imunologiaTolerância Imunológica/imunologiaLeucócitos Mononucleares/imunologiaSubpopulações de Linfócitos T/imunologiaAdultoAntígenos CD45/biossínteseLinfócitos T CD4-Positivos/citologiaProliferação de CélulasFemininoHumanosMemória ImunológicaLeucócitos Mononucleares/citologiaAtivação LinfocitáriaMasculinoProteína Tirosina Fosfatase não Receptora Tipo 1Receptores de Antígenos de Linfócitos T/análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMascarenhas RE Peripheral....pdfMascarenhas RE Peripheral....pdfapplication/pdf104257https://www.arca.fiocruz.br/bitstream/icict/8125/1/Mascarenhas%20RE%20Peripheral....pdf4dc4c7251d1044a9224bd81ccfb7a0a2MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8125/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMascarenhas RE Peripheral....pdf.txtMascarenhas RE Peripheral....pdf.txtExtracted texttext/plain29653https://www.arca.fiocruz.br/bitstream/icict/8125/3/Mascarenhas%20RE%20Peripheral....pdf.txtd9b034418145ec2a85f17a74eebbd943MD53icict/81252023-03-15 14:32:59.271oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
title Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
spellingShingle Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
Mascarenhas, Rita Elizabeth Moreira
Antígenos/imunologia
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Tolerância Imunológica/imunologia
Leucócitos Mononucleares/imunologia
Subpopulações de Linfócitos T/imunologia
Adulto
Antígenos CD45/biossíntese
Linfócitos T CD4-Positivos/citologia
Proliferação de Células
Feminino
Humanos
Memória Imunológica
Leucócitos Mononucleares/citologia
Ativação Linfocitária
Masculino
Proteína Tirosina Fosfatase não Receptora Tipo 1
Receptores de Antígenos de Linfócitos T/análise
title_short Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
title_full Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
title_fullStr Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
title_full_unstemmed Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
title_sort Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
author Mascarenhas, Rita Elizabeth Moreira
author_facet Mascarenhas, Rita Elizabeth Moreira
Brodskyn, Claudia Ida
Barbosa, Geisa
Clarêncio, Jorge
Andrade Filho, Antonio de Souza
Figueiroa, Frederico
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
author_role author
author2 Brodskyn, Claudia Ida
Barbosa, Geisa
Clarêncio, Jorge
Andrade Filho, Antonio de Souza
Figueiroa, Frederico
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mascarenhas, Rita Elizabeth Moreira
Brodskyn, Claudia Ida
Barbosa, Geisa
Clarêncio, Jorge
Andrade Filho, Antonio de Souza
Figueiroa, Frederico
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
dc.subject.decs.pt_BR.fl_str_mv Antígenos/imunologia
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Tolerância Imunológica/imunologia
Leucócitos Mononucleares/imunologia
Subpopulações de Linfócitos T/imunologia
Adulto
Antígenos CD45/biossíntese
Linfócitos T CD4-Positivos/citologia
Proliferação de Células
Feminino
Humanos
Memória Imunológica
Leucócitos Mononucleares/citologia
Ativação Linfocitária
Masculino
Proteína Tirosina Fosfatase não Receptora Tipo 1
Receptores de Antígenos de Linfócitos T/análise
topic Antígenos/imunologia
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Tolerância Imunológica/imunologia
Leucócitos Mononucleares/imunologia
Subpopulações de Linfócitos T/imunologia
Adulto
Antígenos CD45/biossíntese
Linfócitos T CD4-Positivos/citologia
Proliferação de Células
Feminino
Humanos
Memória Imunológica
Leucócitos Mononucleares/citologia
Ativação Linfocitária
Masculino
Proteína Tirosina Fosfatase não Receptora Tipo 1
Receptores de Antígenos de Linfócitos T/análise
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2014-08-04T18:42:15Z
dc.date.available.fl_str_mv 2014-08-04T18:42:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8125
dc.identifier.issn.none.fl_str_mv 1556-6811
dc.identifier.doi.none.fl_str_mv 10.1128/CVI.13.5.547–552.2006
identifier_str_mv MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006.
1556-6811
10.1128/CVI.13.5.547–552.2006
url https://www.arca.fiocruz.br/handle/icict/8125
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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