Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33713 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. |
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Delatorre, EdsonAbreu, Filipe Vieira Santos deRibeiro, Ieda PereiraGómez, Mariela MartínezSantos, Alexandre Araújo Cunha dosBrito, Anielly Ferreira deNeves, Maycon Sebastião Alberto SantosBonelly, IuleMiranda, Rafaella Moraes deFurtado, Nathália DiasRaphael, Lidiane Menezes SouzaSilva, Lucileis de Fátima Fernandes daCastro, Márcia Gonçalves deRamos, Daniel GarkauskasRomano, Alessandro Pecego MartinsKallás, Esper GeorgesVicente, Ana Carolina PauloBello, GonzaloOliveira, Ricardo Lourenço deBonaldo, Myrna Cristina2019-06-28T14:25:42Z2019-06-28T14:25:42Z2019DELATORRE, Edson et al. Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018. Frontiers in Microbiology, v. 10, p. 1-12, May 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3371310.3389/fmicb.2019.01079engFrontiers MediaVìrus da Febre AmarelaSurto brasileiroLinagensFilogeografiaMudanças de aminoácidosYellow fever virusBrazilian outbreakLineagesAmino acid changesPhylogeographyDistinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil / Instituto Federal do Norte de Minas Gerais. Salinas, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil / Instituto de Investigaciones Biológicas Clemente Estable. Departamento de Biología Molecular. División Biología Molecular y Genética. Montevideo, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.Secretaria de Saúde de Goiás. Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Coordenação Geral de Vigilância das Doenças Transmissíveis. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Coordenação Geral de Vigilância das Doenças Transmissíveis. Brasília, DF, Brasil.Universidade de São Paulo. Faculdade de Medicina. Hospital de Clínicas. Departamento de Moléstias Infecciosas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.The current outbreak of yellow fever virus (YFV) that is afflicting Brazil since the end of 2016 probably originated from a re-introduction of YFV from endemic areas into the non-endemic Southeastern Brazil. However, the lack of genomic sequences from endemic regions hinders the tracking of YFV's dissemination routes. We assessed the origin and spread of the ongoing YFV Brazilian outbreak analyzing a new set of YFV strains infecting humans, non-human primates (NHPs) and mosquitoes sampled across five Brazilian states from endemic and non-endemic regions between 2015 and 2018. We found two YFV sub-clade 1E lineages circulating in NHP from Goiás state (GO), resulting from independent viral introductions into the Araguaia tributary river basin: while one strain from 2017 clustered intermingled with Venezuelan YFV strains from 2000, the other YFV strains sampled in 2015 and 2017 clustered with sequences of the current YFV outbreak in the Brazilian Southeastern region (named YFV2015-2018 lineage), displaying the same molecular signature associated to the current YFV outbreak. After its introduction in GO at around mid-2014, the YFV2015-2018 lineage followed two paths of dissemination outside GO, originating two major YFV sub-lineages: (1) the YFVMG/ES/RJ sub-lineage spread sequentially from the eastern area of Minas Gerais state to Espírito Santo and then to Rio de Janeiro states, following the Southeast Atlantic basin; (2) the YFVMG/SP sub-lineage spread from the southwestern area of Minas Gerais to the metropolitan region of São Paulo state, following the Paraná basin. These results indicate the ongoing YFV outbreak in Southeastern Brazil originated from a dissemination event from GO almost 2 years before its recognition at the end of 2016. From GO this lineage was introduced in Minas Gerais state at least two times, originating two sub-lineages that followed different routes toward densely populated areas. The spread of YFV outside endemic regions for at least 4 years stresses the imperative importance of the continuous monitoring of YFV to aid decision-making for effective control policies aiming the increase of vaccination coverage to avoid the YFV transmission in densely populated urban centers.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33713/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAFBrito_RMMiranda_etal_IOC_2019.pdfAFBrito_RMMiranda_etal_IOC_2019.pdfapplication/pdf2040806https://www.arca.fiocruz.br/bitstream/icict/33713/2/AFBrito_RMMiranda_etal_IOC_2019.pdf743895e9684243fccc1591947dfd8281MD52TEXTAFBrito_RMMiranda_etal_IOC_2019.pdf.txtAFBrito_RMMiranda_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| title |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| spellingShingle |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 Delatorre, Edson Vìrus da Febre Amarela Surto brasileiro Linagens Filogeografia Mudanças de aminoácidos Yellow fever virus Brazilian outbreak Lineages Amino acid changes Phylogeography |
| title_short |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| title_full |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| title_fullStr |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| title_full_unstemmed |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| title_sort |
Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018 |
| author |
Delatorre, Edson |
| author_facet |
Delatorre, Edson Abreu, Filipe Vieira Santos de Ribeiro, Ieda Pereira Gómez, Mariela Martínez Santos, Alexandre Araújo Cunha dos Brito, Anielly Ferreira de Neves, Maycon Sebastião Alberto Santos Bonelly, Iule Miranda, Rafaella Moraes de Furtado, Nathália Dias Raphael, Lidiane Menezes Souza Silva, Lucileis de Fátima Fernandes da Castro, Márcia Gonçalves de Ramos, Daniel Garkauskas Romano, Alessandro Pecego Martins Kallás, Esper Georges Vicente, Ana Carolina Paulo Bello, Gonzalo Oliveira, Ricardo Lourenço de Bonaldo, Myrna Cristina |
| author_role |
author |
| author2 |
Abreu, Filipe Vieira Santos de Ribeiro, Ieda Pereira Gómez, Mariela Martínez Santos, Alexandre Araújo Cunha dos Brito, Anielly Ferreira de Neves, Maycon Sebastião Alberto Santos Bonelly, Iule Miranda, Rafaella Moraes de Furtado, Nathália Dias Raphael, Lidiane Menezes Souza Silva, Lucileis de Fátima Fernandes da Castro, Márcia Gonçalves de Ramos, Daniel Garkauskas Romano, Alessandro Pecego Martins Kallás, Esper Georges Vicente, Ana Carolina Paulo Bello, Gonzalo Oliveira, Ricardo Lourenço de Bonaldo, Myrna Cristina |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Delatorre, Edson Abreu, Filipe Vieira Santos de Ribeiro, Ieda Pereira Gómez, Mariela Martínez Santos, Alexandre Araújo Cunha dos Brito, Anielly Ferreira de Neves, Maycon Sebastião Alberto Santos Bonelly, Iule Miranda, Rafaella Moraes de Furtado, Nathália Dias Raphael, Lidiane Menezes Souza Silva, Lucileis de Fátima Fernandes da Castro, Márcia Gonçalves de Ramos, Daniel Garkauskas Romano, Alessandro Pecego Martins Kallás, Esper Georges Vicente, Ana Carolina Paulo Bello, Gonzalo Oliveira, Ricardo Lourenço de Bonaldo, Myrna Cristina |
| dc.subject.other.pt_BR.fl_str_mv |
Vìrus da Febre Amarela Surto brasileiro Linagens Filogeografia Mudanças de aminoácidos |
| topic |
Vìrus da Febre Amarela Surto brasileiro Linagens Filogeografia Mudanças de aminoácidos Yellow fever virus Brazilian outbreak Lineages Amino acid changes Phylogeography |
| dc.subject.en.pt_BR.fl_str_mv |
Yellow fever virus Brazilian outbreak Lineages Amino acid changes Phylogeography |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microorganismos. Rio de Janeiro, RJ. Brasil. |
| publishDate |
2019 |
| dc.date.accessioned.fl_str_mv |
2019-06-28T14:25:42Z |
| dc.date.available.fl_str_mv |
2019-06-28T14:25:42Z |
| dc.date.issued.fl_str_mv |
2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
DELATORRE, Edson et al. Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018. Frontiers in Microbiology, v. 10, p. 1-12, May 2019. |
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https://www.arca.fiocruz.br/handle/icict/33713 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2019.01079 |
| identifier_str_mv |
DELATORRE, Edson et al. Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018. Frontiers in Microbiology, v. 10, p. 1-12, May 2019. 1664-3224 10.3389/fmicb.2019.01079 |
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https://www.arca.fiocruz.br/handle/icict/33713 |
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eng |
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Frontiers Media |
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