CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.

Detalhes bibliográficos
Autor(a) principal: Dantas, Marina Loyola
Data de Publicação: 2013
Outros Autores: Oliveira, Juliana Cabral de, Carvalho, Lucas Pedreira de, Passos, Sara Timóteo, Queiroz, Adriano, Machado, Paulo Roberto, Carvalho Filho, Edgar Marcelino, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7788
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
id CRUZ_19a1b2b746ff7f98bcc529ca3338eaf7
oai_identifier_str oai:www.arca.fiocruz.br:icict/7788
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Dantas, Marina LoyolaOliveira, Juliana Cabral deCarvalho, Lucas Pedreira dePassos, Sara TimóteoQueiroz, AdrianoMachado, Paulo RobertoCarvalho Filho, Edgar MarcelinoArruda, Sérgio Marcos2014-06-04T12:35:44Z2014-06-04T12:35:44Z2013DANTAS, M. L. et al. CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 46, n. 6, p. 728-734, 2013.1678-9849https://www.arca.fiocruz.br/handle/icict/7788dx.doi.org/10.1590/0037-8682-0174-2013engSociedade Brasileira de Medicina TropicalCD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilHospital Universitário Professor Edgard Santos. Universidade Federal da Bahia. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilIntroduction: Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules that progress to ulcers. Although it is already known that T helper cells predominate in the lesions, cytotoxic T cells have also been reported to be present, and their role in leishmaniasis immunopathogenesis is not well known. This study investigated the amounts of CD8+ and granzyme B+ cells in different clinical forms of human cutaneous leishmaniasis (CL). Methods: Forty tissue fragments from early (E-CL) and late CL (L-CL) lesions and from disseminated leishmaniasis (DL) - papules and ulcers - were characterized. The infl amed area per fragment was calculated, and the CD8 and granzyme B expression levels in the infi ltrates were quantifi ed by counting positive cells in 15 fi elds. The localization of CD8 and granzyme B was graded subjectively. Results: Infl ammation was higher in L-CL and DL ulcers. CD8 expression was increased in late ulcerated lesions compared to recent lesions. The increase in CD8+ cells also correlated with the duration of the lesion. Papules had a higher frequency of granzyme B+ cells than E-CL lesions, although the frequency was similar to those for late and DL ulcers. CD8+ cells were mostly found in the papillary dermis. Conclusions: CD8+ T and granzyme B+ cells are present in the infl ammatory infi ltrates of CL and DL and may participate in the immunopathogenesis of Leishmania infection.LeishmaniasisCytotoxicityInfl ammationCutaneous.CD8HumanLinfócitos T CD8-Positivos/enzimologiaLinfócitos T CD8-Positivos/imunologiaGranzimas/imunologiaLeishmaniose Cutânea/imunologiaAdolescenteAdultoCriançaFemininoHumanosImuno-HistoquímicaLeishmaniose Cutânea/patologiaMasculinoMeia-IdadeAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDantas ML CD8+ T cells in situ ....pdfDantas ML CD8+ T cells in situ ....pdfapplication/pdf2478160https://www.arca.fiocruz.br/bitstream/icict/7788/1/Dantas%20ML%20CD8%2b%20T%20cells%20in%20situ%20....pdfff70ece107c21adcef550b94d28d6b52MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7788/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTDantas ML CD8+ T cells in situ ....pdf.txtDantas ML CD8+ T cells in situ ....pdf.txtExtracted texttext/plain27655https://www.arca.fiocruz.br/bitstream/icict/7788/5/Dantas%20ML%20CD8%2b%20T%20cells%20in%20situ%20....pdf.txt0fb17663c007aa157e4331a6161d4650MD55THUMBNAILDantas ML CD8+ T cells in situ ....pdf.jpgDantas ML CD8+ T cells in situ ....pdf.jpgGenerated Thumbnailimage/jpeg2566https://www.arca.fiocruz.br/bitstream/icict/7788/4/Dantas%20ML%20CD8%2b%20T%20cells%20in%20situ%20....pdf.jpgd9bfab5153ff125fba3331e14d2ad7fdMD54icict/77882023-03-15 14:33:18.457oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
title CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
spellingShingle CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
Dantas, Marina Loyola
Leishmaniasis
Cytotoxicity
Infl ammation
Cutaneous.
CD8
Human
Linfócitos T CD8-Positivos/enzimologia
Linfócitos T CD8-Positivos/imunologia
Granzimas/imunologia
Leishmaniose Cutânea/imunologia
Adolescente
Adulto
Criança
Feminino
Humanos
Imuno-Histoquímica
Leishmaniose Cutânea/patologia
Masculino
Meia-Idade
Adulto Jovem
title_short CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
title_full CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
title_fullStr CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
title_full_unstemmed CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
title_sort CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis.
author Dantas, Marina Loyola
author_facet Dantas, Marina Loyola
Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto
Carvalho Filho, Edgar Marcelino
Arruda, Sérgio Marcos
author_role author
author2 Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto
Carvalho Filho, Edgar Marcelino
Arruda, Sérgio Marcos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dantas, Marina Loyola
Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto
Carvalho Filho, Edgar Marcelino
Arruda, Sérgio Marcos
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Cytotoxicity
Infl ammation
Cutaneous.
CD8
Human
Linfócitos T CD8-Positivos/enzimologia
topic Leishmaniasis
Cytotoxicity
Infl ammation
Cutaneous.
CD8
Human
Linfócitos T CD8-Positivos/enzimologia
Linfócitos T CD8-Positivos/imunologia
Granzimas/imunologia
Leishmaniose Cutânea/imunologia
Adolescente
Adulto
Criança
Feminino
Humanos
Imuno-Histoquímica
Leishmaniose Cutânea/patologia
Masculino
Meia-Idade
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Linfócitos T CD8-Positivos/imunologia
Granzimas/imunologia
Leishmaniose Cutânea/imunologia
Adolescente
Adulto
Criança
Feminino
Humanos
Imuno-Histoquímica
Leishmaniose Cutânea/patologia
Masculino
Meia-Idade
Adulto Jovem
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-06-04T12:35:44Z
dc.date.available.fl_str_mv 2014-06-04T12:35:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DANTAS, M. L. et al. CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 46, n. 6, p. 728-734, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7788
dc.identifier.issn.none.fl_str_mv 1678-9849
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1590/0037-8682-0174-2013
identifier_str_mv DANTAS, M. L. et al. CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 46, n. 6, p. 728-734, 2013.
1678-9849
dx.doi.org/10.1590/0037-8682-0174-2013
url https://www.arca.fiocruz.br/handle/icict/7788
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7788/1/Dantas%20ML%20CD8%2b%20T%20cells%20in%20situ%20....pdf
https://www.arca.fiocruz.br/bitstream/icict/7788/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/7788/5/Dantas%20ML%20CD8%2b%20T%20cells%20in%20situ%20....pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/7788/4/Dantas%20ML%20CD8%2b%20T%20cells%20in%20situ%20....pdf.jpg
bitstream.checksum.fl_str_mv ff70ece107c21adcef550b94d28d6b52
7d48279ffeed55da8dfe2f8e81f3b81f
0fb17663c007aa157e4331a6161d4650
d9bfab5153ff125fba3331e14d2ad7fd
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813008880283680768

Registros relacionados