The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33775 |
Resumo: | Universidade Federal da Bahia.Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. |
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Machado, Marılia CarneiroCosta Neto, João Moreira daPortela, Ricardo DiasD’Assis, Mario Jorge Melhor HeineMartins Filho, Olindo AssisMelo, Stella Maria BarrouinBorges, Natalie FerreiraSilva, Fabiana LessaLima, Alessandra Estrela2019-07-02T14:26:30Z2019-07-02T14:26:30Z2018MACHADO, Marılia Carneiro et al. The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma. PLoS One, v. 13, n. 10, p. 1-16, 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/3377510.1371/journal.pone.0204830engPublic Library of ScienceCancer da mamaMammary carcinomaThe effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia.Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil.Universidade Federal da Bahia.Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunologia e Biologia Molecular. Salvador, BA, Brasil.Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoramento.Belo Horizonte, MG, Brasil.Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil.Centro de Ciências Agrárias, Ambientais e Biológicas. Universidade Federal de Reconcavo da Bahia. Cruz das Almas, BA, Brasil.Departamento de Ciências Agrárias e Ambientais. Universidade Estadual de Santa Cruz. Ilhéus, BA, Brasil.Universidade Federal da Bahia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil.The objective of this study was to evaluate the effect of low-dose naltrexone (LDN) as a carboplatin chemotherapy-associated drug in female dogs with mammary carcinoma in benign mixed tumors (MC-BMT) after mastectomy and to assess its association with quality of life and survival rates. Sixty female dogs were included in this study, all of which had histopathological diagnosis of MC-BMT and were divided into three groups: G1 (control), consisting of animals submitted only to mastectomy with or without regional metastasis; G2, composed of treated animals that did not present with metastasis; and G3, treated dogs that presented with metastasis. G2 and G3 were also subdivided according to the treatment administered: chemotherapy alone (MC-BMT(-) C/MC-BMT(+) C) or LDN and chemotherapy (MC-BMT(-) C+LDN/MC-BMT(+) C+LDN). All animals were subjected to clinical evaluation, mastectomy, peripheral blood lymphocyte immunophenotyping, beta-endorphin and met-enkephalin quantification, and evaluation of survival rates and quality of life scores. The results showed higher serum concentrations of beta-endorphin and met-enkephalin, fewer chemotherapy-related side effects, and better quality of life and survival rates in the LDN-treated groups than in LDN-untreated groups (P < 0.05). Evaluation of clinical and pathological parameters indicated a significant association between the use of LDN and both prolonged survival and enhanced quality of life. These results indicate that LDN is a viable chemotherapy-associated treatment in female dogs with MC-BMT, maintaining their quality of life and prolonging survival rates.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/33775/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALThe effect of naltrexone.pdfThe effect of naltrexone.pdfapplication/pdf7506073https://www.arca.fiocruz.br/bitstream/icict/33775/2/The%20effect%20of%20naltrexone.pdf274e17ed74506fb412676882d30b3ab2MD52TEXTThe effect of naltrexone.pdf.txtThe effect of naltrexone.pdf.txtExtracted texttext/plain84https://www.arca.fiocruz.br/bitstream/icict/33775/3/The%20effect%20of%20naltrexone.pdf.txt14a026a18e84bce5da3808ed1c3a59fdMD53icict/337752019-07-03 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| dc.title.pt_BR.fl_str_mv |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| title |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| spellingShingle |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma Machado, Marılia Carneiro Cancer da mama Mammary carcinoma |
| title_short |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| title_full |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| title_fullStr |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| title_full_unstemmed |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| title_sort |
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma |
| author |
Machado, Marılia Carneiro |
| author_facet |
Machado, Marılia Carneiro Costa Neto, João Moreira da Portela, Ricardo Dias D’Assis, Mario Jorge Melhor Heine Martins Filho, Olindo Assis Melo, Stella Maria Barrouin Borges, Natalie Ferreira Silva, Fabiana Lessa Lima, Alessandra Estrela |
| author_role |
author |
| author2 |
Costa Neto, João Moreira da Portela, Ricardo Dias D’Assis, Mario Jorge Melhor Heine Martins Filho, Olindo Assis Melo, Stella Maria Barrouin Borges, Natalie Ferreira Silva, Fabiana Lessa Lima, Alessandra Estrela |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Machado, Marılia Carneiro Costa Neto, João Moreira da Portela, Ricardo Dias D’Assis, Mario Jorge Melhor Heine Martins Filho, Olindo Assis Melo, Stella Maria Barrouin Borges, Natalie Ferreira Silva, Fabiana Lessa Lima, Alessandra Estrela |
| dc.subject.other.pt_BR.fl_str_mv |
Cancer da mama |
| topic |
Cancer da mama Mammary carcinoma |
| dc.subject.en.pt_BR.fl_str_mv |
Mammary carcinoma |
| description |
Universidade Federal da Bahia.Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, Brasil. |
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2018 |
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2018 |
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2019-07-02T14:26:30Z |
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2019-07-02T14:26:30Z |
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MACHADO, Marılia Carneiro et al. The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma. PLoS One, v. 13, n. 10, p. 1-16, 2018. |
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https://www.arca.fiocruz.br/handle/icict/33775 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0204830 |
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MACHADO, Marılia Carneiro et al. The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response, quality of life and survival of dogs with mammary carcinoma. PLoS One, v. 13, n. 10, p. 1-16, 2018. 1932-6203 10.1371/journal.pone.0204830 |
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