Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity

Detalhes bibliográficos
Autor(a) principal: Fonseca, Ana Carolina Proença da
Data de Publicação: 2020
Outros Autores: Fonseca, Guilherme Proença da, Marchesini, Bruna, Voigt, Danielle Dutra, Campos Junior, Mario, Zembrzuski, Verônica Marques, Carneiro, João Regis Ivar, Nogueira Neto, José Firmino, Cabello, Pedro Hernán, Cabello, Giselda Maria Kalil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42050
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
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spelling Fonseca, Ana Carolina Proença daFonseca, Guilherme Proença daMarchesini, BrunaVoigt, Danielle DutraCampos Junior, MarioZembrzuski, Verônica MarquesCarneiro, João Regis IvarNogueira Neto, José FirminoCabello, Pedro HernánCabello, Giselda Maria Kalil2020-07-02T19:31:01Z2020-07-02T19:31:01Z2020FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020.1662-4025https://www.arca.fiocruz.br/handle/icict/4205010.1159/0005056661662-4033engS. Karger AG, BaselVariantes genéticasObesidade graveVia adipocitáriaRiscoSevere ObesityGenetic VariantsAdipocyte PathwayRiskGenetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Genética HUmana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Geneética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Geneética HUmana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, BrasilRegular physical activity has an important role in energy expenditure and combats the development of obesity. During exercise, PPARGC1A is overexpressed, stimulating an increase of the expression of FNDC5. This protein is cleaved to release the hormone irisin, which activates a browning process in white adipose tissue through an increase in UCP1 expression. As a result, irisin leads to mitochondrial heat production and energy expenditure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42050/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrunaMarchesini_PedroCabello_etal_IOC_2020.pdfBrunaMarchesini_PedroCabello_etal_IOC_2020.pdfapplication/pdf646843https://www.arca.fiocruz.br/bitstream/icict/42050/2/BrunaMarchesini_PedroCabello_etal_IOC_2020.pdf3e787562d41d372270b75da2af76ee3eMD52TEXTBrunaMarchesini_PedroCabello_etal_IOC_2020.pdf.txtBrunaMarchesini_PedroCabello_etal_IOC_2020.pdf.txtExtracted texttext/plain50937https://www.arca.fiocruz.br/bitstream/icict/42050/3/BrunaMarchesini_PedroCabello_etal_IOC_2020.pdf.txt2b01b6653111bbb05537e92f065e2664MD53icict/420502020-07-03 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dc.title.pt_BR.fl_str_mv Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
title Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
spellingShingle Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
Fonseca, Ana Carolina Proença da
Variantes genéticas
Obesidade grave
Via adipocitária
Risco
Severe Obesity
Genetic Variants
Adipocyte Pathway
Risk
title_short Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
title_full Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
title_fullStr Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
title_full_unstemmed Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
title_sort Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
author Fonseca, Ana Carolina Proença da
author_facet Fonseca, Ana Carolina Proença da
Fonseca, Guilherme Proença da
Marchesini, Bruna
Voigt, Danielle Dutra
Campos Junior, Mario
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernán
Cabello, Giselda Maria Kalil
author_role author
author2 Fonseca, Guilherme Proença da
Marchesini, Bruna
Voigt, Danielle Dutra
Campos Junior, Mario
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernán
Cabello, Giselda Maria Kalil
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Ana Carolina Proença da
Fonseca, Guilherme Proença da
Marchesini, Bruna
Voigt, Danielle Dutra
Campos Junior, Mario
Zembrzuski, Verônica Marques
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernán
Cabello, Giselda Maria Kalil
dc.subject.other.pt_BR.fl_str_mv Variantes genéticas
Obesidade grave
Via adipocitária
Risco
topic Variantes genéticas
Obesidade grave
Via adipocitária
Risco
Severe Obesity
Genetic Variants
Adipocyte Pathway
Risk
dc.subject.en.pt_BR.fl_str_mv Severe Obesity
Genetic Variants
Adipocyte Pathway
Risk
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-02T19:31:01Z
dc.date.available.fl_str_mv 2020-07-02T19:31:01Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42050
dc.identifier.issn.pt_BR.fl_str_mv 1662-4025
dc.identifier.doi.none.fl_str_mv 10.1159/000505666
dc.identifier.eissn.none.fl_str_mv 1662-4033
identifier_str_mv FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020.
1662-4025
10.1159/000505666
1662-4033
url https://www.arca.fiocruz.br/handle/icict/42050
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv S. Karger AG, Basel
publisher.none.fl_str_mv S. Karger AG, Basel
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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