Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42050 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. |
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Fonseca, Ana Carolina Proença daFonseca, Guilherme Proença daMarchesini, BrunaVoigt, Danielle DutraCampos Junior, MarioZembrzuski, Verônica MarquesCarneiro, João Regis IvarNogueira Neto, José FirminoCabello, Pedro HernánCabello, Giselda Maria Kalil2020-07-02T19:31:01Z2020-07-02T19:31:01Z2020FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020.1662-4025https://www.arca.fiocruz.br/handle/icict/4205010.1159/0005056661662-4033engS. Karger AG, BaselVariantes genéticasObesidade graveVia adipocitáriaRiscoSevere ObesityGenetic VariantsAdipocyte PathwayRiskGenetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Genética HUmana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Grande Rio. Laboratório de Geneética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Geneética HUmana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, BrasilRegular physical activity has an important role in energy expenditure and combats the development of obesity. During exercise, PPARGC1A is overexpressed, stimulating an increase of the expression of FNDC5. This protein is cleaved to release the hormone irisin, which activates a browning process in white adipose tissue through an increase in UCP1 expression. As a result, irisin leads to mitochondrial heat production and energy expenditure.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42050/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBrunaMarchesini_PedroCabello_etal_IOC_2020.pdfBrunaMarchesini_PedroCabello_etal_IOC_2020.pdfapplication/pdf646843https://www.arca.fiocruz.br/bitstream/icict/42050/2/BrunaMarchesini_PedroCabello_etal_IOC_2020.pdf3e787562d41d372270b75da2af76ee3eMD52TEXTBrunaMarchesini_PedroCabello_etal_IOC_2020.pdf.txtBrunaMarchesini_PedroCabello_etal_IOC_2020.pdf.txtExtracted texttext/plain50937https://www.arca.fiocruz.br/bitstream/icict/42050/3/BrunaMarchesini_PedroCabello_etal_IOC_2020.pdf.txt2b01b6653111bbb05537e92f065e2664MD53icict/420502020-07-03 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dc.title.pt_BR.fl_str_mv |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
title |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
spellingShingle |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity Fonseca, Ana Carolina Proença da Variantes genéticas Obesidade grave Via adipocitária Risco Severe Obesity Genetic Variants Adipocyte Pathway Risk |
title_short |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
title_full |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
title_fullStr |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
title_full_unstemmed |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
title_sort |
Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity |
author |
Fonseca, Ana Carolina Proença da |
author_facet |
Fonseca, Ana Carolina Proença da Fonseca, Guilherme Proença da Marchesini, Bruna Voigt, Danielle Dutra Campos Junior, Mario Zembrzuski, Verônica Marques Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Pedro Hernán Cabello, Giselda Maria Kalil |
author_role |
author |
author2 |
Fonseca, Guilherme Proença da Marchesini, Bruna Voigt, Danielle Dutra Campos Junior, Mario Zembrzuski, Verônica Marques Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Pedro Hernán Cabello, Giselda Maria Kalil |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fonseca, Ana Carolina Proença da Fonseca, Guilherme Proença da Marchesini, Bruna Voigt, Danielle Dutra Campos Junior, Mario Zembrzuski, Verônica Marques Carneiro, João Regis Ivar Nogueira Neto, José Firmino Cabello, Pedro Hernán Cabello, Giselda Maria Kalil |
dc.subject.other.pt_BR.fl_str_mv |
Variantes genéticas Obesidade grave Via adipocitária Risco |
topic |
Variantes genéticas Obesidade grave Via adipocitária Risco Severe Obesity Genetic Variants Adipocyte Pathway Risk |
dc.subject.en.pt_BR.fl_str_mv |
Severe Obesity Genetic Variants Adipocyte Pathway Risk |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-07-02T19:31:01Z |
dc.date.available.fl_str_mv |
2020-07-02T19:31:01Z |
dc.date.issued.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/42050 |
dc.identifier.issn.pt_BR.fl_str_mv |
1662-4025 |
dc.identifier.doi.none.fl_str_mv |
10.1159/000505666 |
dc.identifier.eissn.none.fl_str_mv |
1662-4033 |
identifier_str_mv |
FONSECA, Ana Carolina Proença da et al. Genetic Variants in the Activation of the Brown-Like Adipocyte Pathway and the Risk for Severe Obesity. Obesity Facts, v. 13, p. 130-143, 2020. 1662-4025 10.1159/000505666 1662-4033 |
url |
https://www.arca.fiocruz.br/handle/icict/42050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
S. Karger AG, Basel |
publisher.none.fl_str_mv |
S. Karger AG, Basel |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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