Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients

Detalhes bibliográficos
Autor(a) principal: Van Weyenbergh, Johan Jozef Rosa Maria
Data de Publicação: 1998
Outros Autores: Lipinski, Pawel, Abadie, Annie, Chabas, Dorothé, Blank, Ulrich, Liblau, Roland, Wietzerbin, Juana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11014
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / nstitut National de la Santé et de la Recherche Médicale (INSERM). Institut Curie. Paris, France
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spelling Van Weyenbergh, Johan Jozef Rosa MariaLipinski, PawelAbadie, AnnieChabas, DorothéBlank, UlrichLiblau, RolandWietzerbin, Juana2015-06-30T14:24:03Z2015-06-30T14:24:03Z1998Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients. Journal of Immunology, v. 161, n. 3, p. 1568-1574, 1998.0022-1767https://www.arca.fiocruz.br/handle/icict/11014engAmerican Association of ImmunologistsAntagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / nstitut National de la Santé et de la Recherche Médicale (INSERM). Institut Curie. Paris, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM). Institut Curie. Paris, FranceInstitut National de la Santé et de la Recherche Médicale (INSERM). Institut Curie. Paris, FranceHôpital Pitié-Salpêtrière. Fédération de Neurologie et INSERM. Laboratoire d’Immunologie Cellulaire. Paris, FranceInstitut Pasteur. Unité d’Immuno-Allergie. Paris, FranceHôpital Pitié-Salpêtrière. Fédération de Neurologie et INSERM. Laboratoire d’Immunologie Cellulaire. Paris, Francenstitut National de la Santé et de la Recherche Médicale (INSERM). Institut Curie. Paris, FranceMonocyte-macrophage activation by IFN-g is characterized by a pronounced increase of high affinity Fc receptors for IgG (FcgRI), capable of triggering respiratory burst, phagocytosis, Ab-dependent cytotoxicity, and release of proinflammatory cytokines. In view of the antagonism of IFN-b on IFN-g action, of interest in the chronic inflammatory disorder multiple sclerosis, we examined the possible effect of IFN-b on IFN-g induction of FcgRI gene expression. We found that IFN-b significantly downregulated IFN-g-induced FcgRI surface expression in peripheral blood monocytes from healthy donors, in a dose- and timedependent manner. This down-regulation of FcgRI surface levels did not correspond to a decrease in FcgRI mRNA, suggesting a posttranscriptional effect of IFN-b. Down-regulation of FcgRI surface expression correlated with diminished cellular signaling through FcgRI, since the IFN-g-induced increase in Fcg receptor-triggered respiratory burst was nearly completely abrogated by simultaneous addition of IFN-b. Finally, the same antagonism between both IFNs on FcgRI surface expression was observed in peripheral blood monocytes derived from multiple sclerosis patients; inhibition by IFN-b was even increased (82 6 11%), as compared with healthy controls (67 6 4%). These results may partially help explain the beneficial effect of IFN-b in multiple sclerosis.Interferon beta/farmacologiaInterferon gama/farmacologiaEsclerose Múltipla/imunologiaReceptores de IgG/antagonistas & inibidoresReceptores de IgG/biossínteseAdultoCélulas CultivadasCitocinas/secreçãoRelação Dose-Resposta ImunológicaFemininoHumanosLíquido Intracelular/imunologiaMasculinoProteínas de Membrana/antagonistas & inibidoresMeia-IdadeMonócitos/efeitos de drogasEsclerose Múltipla/genéticaRNA Mensageiro/biossínteseReceptores de IgG/sangueExplosão Respiratória/efeitos de drogasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11014/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALVan Weyenbergh J Antagonistic Action of....pdfVan Weyenbergh J Antagonistic Action of....pdfapplication/pdf94127https://www.arca.fiocruz.br/bitstream/icict/11014/2/Van%20Weyenbergh%20J%20Antagonistic%20Action%20of....pdf84f1c90cf16e7fe9dcf404927c7e2f65MD52TEXTVan Weyenbergh J Antagonistic Action of....pdf.txtVan Weyenbergh J Antagonistic Action of....pdf.txtExtracted texttext/plain45131https://www.arca.fiocruz.br/bitstream/icict/11014/3/Van%20Weyenbergh%20J%20Antagonistic%20Action%20of....pdf.txtc971547c552574df6c10da499a0a9e19MD53icict/110142023-03-15 14:32:55.505oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
title Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
spellingShingle Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
Van Weyenbergh, Johan Jozef Rosa Maria
Interferon beta/farmacologia
Interferon gama/farmacologia
Esclerose Múltipla/imunologia
Receptores de IgG/antagonistas & inibidores
Receptores de IgG/biossíntese
Adulto
Células Cultivadas
Citocinas/secreção
Relação Dose-Resposta Imunológica
Feminino
Humanos
Líquido Intracelular/imunologia
Masculino
Proteínas de Membrana/antagonistas & inibidores
Meia-Idade
Monócitos/efeitos de drogas
Esclerose Múltipla/genética
RNA Mensageiro/biossíntese
Receptores de IgG/sangue
Explosão Respiratória/efeitos de drogas
title_short Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
title_full Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
title_fullStr Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
title_full_unstemmed Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
title_sort Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients
author Van Weyenbergh, Johan Jozef Rosa Maria
author_facet Van Weyenbergh, Johan Jozef Rosa Maria
Lipinski, Pawel
Abadie, Annie
Chabas, Dorothé
Blank, Ulrich
Liblau, Roland
Wietzerbin, Juana
author_role author
author2 Lipinski, Pawel
Abadie, Annie
Chabas, Dorothé
Blank, Ulrich
Liblau, Roland
Wietzerbin, Juana
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Van Weyenbergh, Johan Jozef Rosa Maria
Lipinski, Pawel
Abadie, Annie
Chabas, Dorothé
Blank, Ulrich
Liblau, Roland
Wietzerbin, Juana
dc.subject.decs.pt_BR.fl_str_mv Interferon beta/farmacologia
Interferon gama/farmacologia
Esclerose Múltipla/imunologia
Receptores de IgG/antagonistas & inibidores
Receptores de IgG/biossíntese
Adulto
Células Cultivadas
Citocinas/secreção
Relação Dose-Resposta Imunológica
Feminino
Humanos
Líquido Intracelular/imunologia
Masculino
Proteínas de Membrana/antagonistas & inibidores
Meia-Idade
Monócitos/efeitos de drogas
Esclerose Múltipla/genética
RNA Mensageiro/biossíntese
Receptores de IgG/sangue
Explosão Respiratória/efeitos de drogas
topic Interferon beta/farmacologia
Interferon gama/farmacologia
Esclerose Múltipla/imunologia
Receptores de IgG/antagonistas & inibidores
Receptores de IgG/biossíntese
Adulto
Células Cultivadas
Citocinas/secreção
Relação Dose-Resposta Imunológica
Feminino
Humanos
Líquido Intracelular/imunologia
Masculino
Proteínas de Membrana/antagonistas & inibidores
Meia-Idade
Monócitos/efeitos de drogas
Esclerose Múltipla/genética
RNA Mensageiro/biossíntese
Receptores de IgG/sangue
Explosão Respiratória/efeitos de drogas
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / nstitut National de la Santé et de la Recherche Médicale (INSERM). Institut Curie. Paris, France
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2015-06-30T14:24:03Z
dc.date.available.fl_str_mv 2015-06-30T14:24:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients. Journal of Immunology, v. 161, n. 3, p. 1568-1574, 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11014
dc.identifier.issn.none.fl_str_mv 0022-1767
identifier_str_mv Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc gamma receptor expression in healthy controls and multiple sclerosis patients. Journal of Immunology, v. 161, n. 3, p. 1568-1574, 1998.
0022-1767
url https://www.arca.fiocruz.br/handle/icict/11014
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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