COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease

Detalhes bibliográficos
Autor(a) principal: Carvalho, Lilian V.S
Data de Publicação: 2022
Outros Autores: Souza, Cassiana da Silva, Fontes, Jonathan L.M, Cardoso, Lara, Salomar, Milton, Duarte Neto, Amaro Nunes, Figueira, Claudio, Brito, Reginaldo, Mesquita, Bianca, Freitas, Luiz A.R. de, Oliveira, Geraldo G.S, Santos, Washington L. C. dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51674
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). FIOCRUZ Inova
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spelling Carvalho, Lilian V.SSouza, Cassiana da SilvaFontes, Jonathan L.MCardoso, LaraSalomar, MiltonDuarte Neto, Amaro NunesFigueira, ClaudioBrito, ReginaldoMesquita, BiancaFreitas, Luiz A.R. deOliveira, Geraldo G.SSantos, Washington L. C. dos2022-03-10T14:33:44Z2022-03-10T14:33:44Z2022Carvalho, Lilian V.S. et al. COVID-19 beyond DAD: persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease. Human Pathology, v. 27, p. 1-4, 2022.0046-8177https://www.arca.fiocruz.br/handle/icict/51674doi.org/10.1016/j.hpr.2022.300607Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). FIOCRUZ InovaInstituto Couto Maia. Salvador, BA, Brasil.Instituto Couto Maia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.Background: Despite advances in the management of COVID-19, some events occurring in the course of disease still represent challenges to patient treatment. Case presentation: Here we present a case of severe COVID-19 in which the patient received standard treatment including dexamethasone and prophylactic anticoagulation and died on the 24th day of disease. Autopsy showed exudative and proliferative DAD accompanied by remaining microcirculation thrombosis despite anticoagulation treatment, unperceived fungal infection, concomitantly with the presence of dense acellular fibrotic areas amidst organizing lung lesions. Conclusions: Although improvements were achieved in COVID-19 therapeutics lung microcirculation coagulopathy, unperceived fungus infection and early developing alveolar fibrosis remain unsolved problems associated to the disease.engElsevierCOVID-19AutopsiaCoagulação Intravascular DisseminadaCOVID-19AutopsyDisseminated Intravascular CoagulationCOVID-19AutopsiaCoagulación Intravascular DiseminadaCoronavirusAutopsieCoagulation intravasculaire disséminéeCOVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51674/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho, L. V.S. COVID-19 beyond ....pdfCarvalho, L. V.S. 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dc.title.pt_BR.fl_str_mv COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
title COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
spellingShingle COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
Carvalho, Lilian V.S
COVID-19
Autopsia
Coagulação Intravascular Disseminada
COVID-19
Autopsy
Disseminated Intravascular Coagulation
COVID-19
Autopsia
Coagulación Intravascular Diseminada
Coronavirus
Autopsie
Coagulation intravasculaire disséminée
title_short COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
title_full COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
title_fullStr COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
title_full_unstemmed COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
title_sort COVID-19 beyond DAD: Persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease
author Carvalho, Lilian V.S
author_facet Carvalho, Lilian V.S
Souza, Cassiana da Silva
Fontes, Jonathan L.M
Cardoso, Lara
Salomar, Milton
Duarte Neto, Amaro Nunes
Figueira, Claudio
Brito, Reginaldo
Mesquita, Bianca
Freitas, Luiz A.R. de
Oliveira, Geraldo G.S
Santos, Washington L. C. dos
author_role author
author2 Souza, Cassiana da Silva
Fontes, Jonathan L.M
Cardoso, Lara
Salomar, Milton
Duarte Neto, Amaro Nunes
Figueira, Claudio
Brito, Reginaldo
Mesquita, Bianca
Freitas, Luiz A.R. de
Oliveira, Geraldo G.S
Santos, Washington L. C. dos
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Lilian V.S
Souza, Cassiana da Silva
Fontes, Jonathan L.M
Cardoso, Lara
Salomar, Milton
Duarte Neto, Amaro Nunes
Figueira, Claudio
Brito, Reginaldo
Mesquita, Bianca
Freitas, Luiz A.R. de
Oliveira, Geraldo G.S
Santos, Washington L. C. dos
dc.subject.other.pt_BR.fl_str_mv COVID-19
Autopsia
Coagulação Intravascular Disseminada
topic COVID-19
Autopsia
Coagulação Intravascular Disseminada
COVID-19
Autopsy
Disseminated Intravascular Coagulation
COVID-19
Autopsia
Coagulación Intravascular Diseminada
Coronavirus
Autopsie
Coagulation intravasculaire disséminée
dc.subject.en.pt_BR.fl_str_mv COVID-19
Autopsy
Disseminated Intravascular Coagulation
dc.subject.es.pt_BR.fl_str_mv COVID-19
Autopsia
Coagulación Intravascular Diseminada
dc.subject.fr.pt_BR.fl_str_mv Coronavirus
Autopsie
Coagulation intravasculaire disséminée
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). FIOCRUZ Inova
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-10T14:33:44Z
dc.date.available.fl_str_mv 2022-03-10T14:33:44Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Carvalho, Lilian V.S. et al. COVID-19 beyond DAD: persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease. Human Pathology, v. 27, p. 1-4, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51674
dc.identifier.issn.pt_BR.fl_str_mv 0046-8177
dc.identifier.doi.none.fl_str_mv doi.org/10.1016/j.hpr.2022.300607
identifier_str_mv Carvalho, Lilian V.S. et al. COVID-19 beyond DAD: persisting microcirculation thrombosis, hidden infections, and early pulmonary fibrosis as remaining challenges of the disease. Human Pathology, v. 27, p. 1-4, 2022.
0046-8177
doi.org/10.1016/j.hpr.2022.300607
url https://www.arca.fiocruz.br/handle/icict/51674
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51674/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51674/2/Carvalho%2c%20L.%20V.S.%20COVID-19%20beyond%20....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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