The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

Detalhes bibliográficos
Autor(a) principal: Dolens, Eder da Silva
Data de Publicação: 2021
Outros Autores: Dourado, Mauricio Rocha, Almangush, Alhadi, Salo, Tuula A., Rocha, Clarissa Araujo Gurgel, Silva, Sabrina Daniela da, Brennan, Peter A., Coletta, Ricardo D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50216
Resumo: Fundação deAmparo à Pesquisa do Estado de São Paulo (FAPESP) (2018/16077-6) and the Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq) (407814/2018-3 and 303589/2019-1). MD was research fellow supported by FAPESP (2017/26764-8).
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spelling Dolens, Eder da SilvaDourado, Mauricio RochaAlmangush, AlhadiSalo, Tuula A.Rocha, Clarissa Araujo GurgelSilva, Sabrina Daniela daBrennan, Peter A.Coletta, Ricardo D.2021-12-08T17:19:11Z2021-12-08T17:19:11Z2021DOLENS, Eder da Silva et al. The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis. Frontiers in Oncology, p. 1-3, 10 Nov. 2021.2234-943Xhttps://www.arca.fiocruz.br/handle/icict/5021610.3389/fonc.2021.784924Fundação deAmparo à Pesquisa do Estado de São Paulo (FAPESP) (2018/16077-6) and the Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq) (407814/2018-3 and 303589/2019-1). MD was research fellow supported by FAPESP (2017/26764-8).University of Campinas. School of Dentistry. Graduate Program in Oral Biology. Piracicaba, SP, Brazil / University of Western São Paulo. Presidente Prudente, SP, Brazil.University of Campinas. Department of Oral Diagnosis, School of Dentistry. Piracicaba, SP, Brazil.University of Helsinki. Department of Oral and Maxillofacial Diseases. Helsinki, Finland / University of Helsinki. Department of Pathology. Helsinki, Finland.University of Helsinki. Department of Oral and Maxillofacial Diseases. Helsinki, Finland / University of Helsinki. Department of Pathology. Helsinki, Finland. / University of Oulu and Oulu University Hospital. Cancer and Translational Medicine Research Unit. Medical Research Center Oulu. Oulu, Finland.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Department of Propaedeutics. Salvador, Ba, Brazil.McGill University. Faculty of Medicine. Sir Mortimer B. Davis-Jewish General Hospital. Department of Otolaryngology Head and Neck Surgery. Montreal, QC, Canada / McGill University. Faculty of Medicine. Sir Mortimer B. Davis-Jewish General Hospital. Segal Cancer Centre and Lady Davis Institute for Medical Research. Department of Experimental Medicine. Montreal, QC, Canada.Queen Alexandra Hospital. Department of Oral and Maxillofacial Surgery. Portsmouth, United Kingdom.University of Campinas. School of Dentistry. Graduate Program in Oral Biology. Piracicaba, SP, Brazil / University of Campinas. Department of Oral Diagnosis, School of Dentistry. Piracicaba, SP, Brazil.Objective: Over many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature. Methods: A systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. Results: The study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high. Conclusion: Our results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis. Systematic Review Registration: International Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630.engFrontiers MediaMarcadoresPrognósticoCâncer oralRevisão sistemáticaMeta-análiseHistopathological markersPrognosisOral cancerSystematic reviewMeta-analysisThe Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50216/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALDolens, Eder da Silva The impact....pdfDolens, Eder da Silva The 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dc.title.pt_BR.fl_str_mv The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
spellingShingle The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
Dolens, Eder da Silva
Marcadores
Prognóstico
Câncer oral
Revisão sistemática
Meta-análise
Histopathological markers
Prognosis
Oral cancer
Systematic review
Meta-analysis
title_short The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_full The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_fullStr The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_full_unstemmed The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
title_sort The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis
author Dolens, Eder da Silva
author_facet Dolens, Eder da Silva
Dourado, Mauricio Rocha
Almangush, Alhadi
Salo, Tuula A.
Rocha, Clarissa Araujo Gurgel
Silva, Sabrina Daniela da
Brennan, Peter A.
Coletta, Ricardo D.
author_role author
author2 Dourado, Mauricio Rocha
Almangush, Alhadi
Salo, Tuula A.
Rocha, Clarissa Araujo Gurgel
Silva, Sabrina Daniela da
Brennan, Peter A.
Coletta, Ricardo D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dolens, Eder da Silva
Dourado, Mauricio Rocha
Almangush, Alhadi
Salo, Tuula A.
Rocha, Clarissa Araujo Gurgel
Silva, Sabrina Daniela da
Brennan, Peter A.
Coletta, Ricardo D.
dc.subject.other.pt_BR.fl_str_mv Marcadores
Prognóstico
Câncer oral
Revisão sistemática
Meta-análise
topic Marcadores
Prognóstico
Câncer oral
Revisão sistemática
Meta-análise
Histopathological markers
Prognosis
Oral cancer
Systematic review
Meta-analysis
dc.subject.en.pt_BR.fl_str_mv Histopathological markers
Prognosis
Oral cancer
Systematic review
Meta-analysis
description Fundação deAmparo à Pesquisa do Estado de São Paulo (FAPESP) (2018/16077-6) and the Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq) (407814/2018-3 and 303589/2019-1). MD was research fellow supported by FAPESP (2017/26764-8).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-08T17:19:11Z
dc.date.available.fl_str_mv 2021-12-08T17:19:11Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DOLENS, Eder da Silva et al. The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis. Frontiers in Oncology, p. 1-3, 10 Nov. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50216
dc.identifier.issn.pt_BR.fl_str_mv 2234-943X
dc.identifier.doi.none.fl_str_mv 10.3389/fonc.2021.784924
identifier_str_mv DOLENS, Eder da Silva et al. The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis. Frontiers in Oncology, p. 1-3, 10 Nov. 2021.
2234-943X
10.3389/fonc.2021.784924
url https://www.arca.fiocruz.br/handle/icict/50216
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/50216/2/Dolens%2c%20Eder%20da%20Silva%20The%20impact....pdf
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