Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma

Detalhes bibliográficos
Autor(a) principal: Magalhães, Marcelo
Data de Publicação: 2015
Outros Autores: Oliveira, Pedro Dantas, Bittencourt, Achilea Candida Lisboa, Farre, Lourdes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pntd.0003403
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13735
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
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spelling Magalhães, MarceloOliveira, Pedro DantasBittencourt, Achilea Candida LisboaFarre, Lourdes2016-04-12T17:51:50Z2016-04-12T17:51:50Z2015MAGALHÃES, M. et al. Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma. PLoS Neglected Tropical Diseases, v. 9, n. 1, p. e0003403, 2015.1935-2735https://www.arca.fiocruz.br/handle/icict/1373510.1371/journal.pntd.0003403porPublic Library of ScienceMicrosatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Departamento de Dermatologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Departamento de Patologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. INCT. Salvador, BA, BrasilBACKGROUND: Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell neoplasia etiologically linked to HTLV-1. Manifestations of ATL are diverse and different clinical types with different tissue involvement and aggressiveness have been described. The mechanisms that lead to the development of ATL clinical types have not yet been clarified. Considering that in ATL patients HTLV-1 infection generally occurs in childhood, a multistep carcinogenesis model has been proposed. Microsatellite alterations are important genetic events in cancer development and these alterations have been reported in the aggressive types of ATL. Little is known about oncogenesis of the less aggressive types. METHODOLOGY/PRINCIPAL FINDINGS: In this study we investigated the role of the microsatellite alterations in the pathogenesis mediated by HTLV-1 in the different types of ATL. We examined the presence of microsatellite instability (MSI) and loss of heterozigosity (LOH) in matched pair samples (tumoral and normal) of 24 patients with less aggressive types (smoldering and chronic) and in aggressive types (acute and lymphoma) of ATL. Four microsatellite markers D10S190, D10S191, D1391 and DCC were analyzed. MSI was found in four patients, three smoldering and one chronic, and LOH in four patients, three smoldering and one acute. None of the smoldering patients with microsatellite alterations progressed to aggressive ATL. CONCLUSIONS/SIGNIFICANCE: To our knowledge, this is the first report describing the presence of MSI and LOH in the less aggressive types of ATL. These results indicate that microsatellite alterations may participate in the development of the less aggressive types of ATLInfecções por HTLV-I/complicaçõesVírus 1 Linfotrópico T HumanoLeucemia-Linfoma de Células T do Adulto/genéticaLeucemia-Linfoma de Células T do Adulto/virologiaRepetições de Microssatélites/genéticaAdultoFemininoPredisposição Genética para DoençaHumanosMasculinoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13735/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMagalhaes, M. Microsatellite alterations....pdfMagalhaes, M. Microsatellite alterations....pdfapplication/pdf320318https://www.arca.fiocruz.br/bitstream/icict/13735/2/Magalhaes%2c%20M.%20Microsatellite%20alterations....pdff7780b37b7d568b38ab42107147e4d61MD52TEXTMagalhaes, M. Microsatellite alterations....pdf.txtMagalhaes, M. 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dc.title.pt_BR.fl_str_mv Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
title Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
spellingShingle Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
Magalhães, Marcelo
Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano
Leucemia-Linfoma de Células T do Adulto/genética
Leucemia-Linfoma de Células T do Adulto/virologia
Repetições de Microssatélites/genética
Adulto
Feminino
Predisposição Genética para Doença
Humanos
Masculino
title_short Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
title_full Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
title_fullStr Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
title_full_unstemmed Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
title_sort Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma
author Magalhães, Marcelo
author_facet Magalhães, Marcelo
Oliveira, Pedro Dantas
Bittencourt, Achilea Candida Lisboa
Farre, Lourdes
author_role author
author2 Oliveira, Pedro Dantas
Bittencourt, Achilea Candida Lisboa
Farre, Lourdes
author2_role author
author
author
dc.contributor.author.fl_str_mv Magalhães, Marcelo
Oliveira, Pedro Dantas
Bittencourt, Achilea Candida Lisboa
Farre, Lourdes
dc.subject.decs.pt_BR.fl_str_mv Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano
Leucemia-Linfoma de Células T do Adulto/genética
Leucemia-Linfoma de Células T do Adulto/virologia
Repetições de Microssatélites/genética
Adulto
Feminino
Predisposição Genética para Doença
Humanos
Masculino
topic Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano
Leucemia-Linfoma de Células T do Adulto/genética
Leucemia-Linfoma de Células T do Adulto/virologia
Repetições de Microssatélites/genética
Adulto
Feminino
Predisposição Genética para Doença
Humanos
Masculino
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-04-12T17:51:50Z
dc.date.available.fl_str_mv 2016-04-12T17:51:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAGALHÃES, M. et al. Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma. PLoS Neglected Tropical Diseases, v. 9, n. 1, p. e0003403, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13735
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0003403
identifier_str_mv MAGALHÃES, M. et al. Microsatellite alterations are also present in the less aggressive types of adult T-cell leukemia-lymphoma. PLoS Neglected Tropical Diseases, v. 9, n. 1, p. e0003403, 2015.
1935-2735
10.1371/journal.pntd.0003403
url https://www.arca.fiocruz.br/handle/icict/13735
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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