An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/27155 |
Resumo: | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmaceuticos. Belo Horizonte, MG, Brazil |
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Silva, Pedro Henrique Reis daEnéas, Paula Cristina RezendeFernandes, ChristianPianetti, Gerson Antônio2018-06-27T14:53:12Z2018-06-27T14:53:12Z2017SILVA, Pedro Henrique Reis da et al. An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules. Braz. J. Pharm. Sci, v. 53, n. 2, e16064, 2017.2175-9790https://www.arca.fiocruz.br/handle/icict/2715510.1590/s2175-97902017000216064engUniversidade de São PauloPrednisonacapsulasCromatografia líquida de alta eficiência / validaçãoAvaliação da linearidadePrednisoneCapsulesHigh performance liquid chromatography/validationLinearity assessmentAn innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsulesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmaceuticos. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmaceuticos. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmaceuticos. Belo Horizonte, MG, BrazilPrednisone is an anti-inflammatory steroid drug widely used in clinical practice. However, no high-performance liquid chromatographic (HPLC) method has been described in the literature for the determination of prednisone in capsules until now. Thus, an HPLC method was developed using a C18 (250x4.0, 5 µm) column, with methanol:water (70:30) as mobile phase at a flow rate of 1 mL/min and detection at 240 nm. The developed method was validated following current Brazilian legislation. Additionally, linearity was assessed by evaluating the assumptions of normality, homoscedasticity, and independency of residuals, and the fit to the linear model. The method showed linearity (r2>0.99) over the range of 14.0-26.0 µg/mL, selectivity, precision (RSD<2.0%), robustness, and accuracy (average recovery of 100.05%). The chromatographic procedure was applied for assay and uniformity content determination of three different batches of prednisone capsules, showing to be suitable for their quality control.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/27155/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALAn innovative, simple, fast,.pdfAn innovative, simple, fast,.pdfapplication/pdf401694https://www.arca.fiocruz.br/bitstream/icict/27155/2/An%20innovative%2c%20simple%2c%20fast%2c.pdfb36672d4b399a1db6f0f3dc5a99dfd6dMD52TEXTAn innovative, simple, fast,.pdf.txtAn innovative, simple, fast,.pdf.txtExtracted texttext/plain24251https://www.arca.fiocruz.br/bitstream/icict/27155/3/An%20innovative%2c%20simple%2c%20fast%2c.pdf.txt594e71ded5592d6252b1cfd3da94a0eeMD53icict/271552019-06-19 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dc.title.pt_BR.fl_str_mv |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
title |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
spellingShingle |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules Silva, Pedro Henrique Reis da Prednisona capsulas Cromatografia líquida de alta eficiência / validação Avaliação da linearidade Prednisone Capsules High performance liquid chromatography/validation Linearity assessment |
title_short |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
title_full |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
title_fullStr |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
title_full_unstemmed |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
title_sort |
An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules |
author |
Silva, Pedro Henrique Reis da |
author_facet |
Silva, Pedro Henrique Reis da Enéas, Paula Cristina Rezende Fernandes, Christian Pianetti, Gerson Antônio |
author_role |
author |
author2 |
Enéas, Paula Cristina Rezende Fernandes, Christian Pianetti, Gerson Antônio |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Pedro Henrique Reis da Enéas, Paula Cristina Rezende Fernandes, Christian Pianetti, Gerson Antônio |
dc.subject.other.pt_BR.fl_str_mv |
Prednisona capsulas Cromatografia líquida de alta eficiência / validação Avaliação da linearidade |
topic |
Prednisona capsulas Cromatografia líquida de alta eficiência / validação Avaliação da linearidade Prednisone Capsules High performance liquid chromatography/validation Linearity assessment |
dc.subject.en.pt_BR.fl_str_mv |
Prednisone Capsules High performance liquid chromatography/validation Linearity assessment |
description |
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmaceuticos. Belo Horizonte, MG, Brazil |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2018-06-27T14:53:12Z |
dc.date.available.fl_str_mv |
2018-06-27T14:53:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Pedro Henrique Reis da et al. An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules. Braz. J. Pharm. Sci, v. 53, n. 2, e16064, 2017. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/27155 |
dc.identifier.issn.pt_BR.fl_str_mv |
2175-9790 |
dc.identifier.doi.none.fl_str_mv |
10.1590/s2175-97902017000216064 |
identifier_str_mv |
SILVA, Pedro Henrique Reis da et al. An innovative, simple, fast, and less toxic high-performance liquid chromatographic method for determination of prednisone in capsules. Braz. J. Pharm. Sci, v. 53, n. 2, e16064, 2017. 2175-9790 10.1590/s2175-97902017000216064 |
url |
https://www.arca.fiocruz.br/handle/icict/27155 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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