Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/S1678-9946201961071 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40530 |
Resumo: | Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil. |
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Eyer-Silva, Walter de AraujoAlmeida, Marina Rodrigues deMartins, Carlos JoséOliveira, Rodrigo Panno Basílio deAraujo, Luciana Ferreira deOliveira, Carlos Alberto Basílio deAzevedo, Marcelo Costa Velho Mendes dePinto, Jorge Francisco da CunhaVasconcellos, Sidra Ezidio GonçalvesSantos, Ícaro Rodrigues DosGomes, Harrison MagdinierSuffys, Philip Noel2020-03-26T20:58:16Z2020-03-26T20:58:16Z2019EYER-SILVA, Walter de Araujo et al. Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 61, p. 1-6, Nov. 2019.0036-4665https://www.arca.fiocruz.br/handle/icict/4053010.1590/S1678-99462019610711678-9946engUniversidade de São PauloAIDSMycobacterium haemophilumInfecção pelo HIVSíndrome Inflamatória de Reconstituição ImunológicaMycobacterium não tuberculosoAIDSHIV infectionImmune Reconstitution Inflammatory SyndromeMycobacterium haemophilumNontuberculous mycobacteriumAntiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ, Brasil.Mycobacterium haemophilum is a nontuberculous mycobacterium that causes localized or disseminated disease, mainly in immunocompromised hosts. We report the case of a 35-year-old HIV-infected woman who presented with several enlarging cutaneous lesions over the arms and legs. Histopathological examination revealed the diagnosis of a cutaneous mycobacterial disease. Mycobacterial analyses unveiled M. haemophilum infection. Six months after completion of a successful antimycobacterial treatment, she developed an immune reconstitution inflammatory syndrome (IRIS). This paradoxical relapse presented as tenderness, redness and swelling at the precise sites of the healed lesions and took place in the setting of significant recovery of the CD4 cell count (from 05 to 318 cells/mm 3 ). Microbiological analyses of these worsening lesions were negative, and they spontaneously remitted without the initiation of a novel antimycobacterial treatment cycle. M. haemophilum infection should always be considered as a cause of skin lesions in immunocompromised subjects. Physicians should be aware of the possibility of IRIS as a complication of successful antiretroviral therapy in HIV-infected patients with M. haemophilum infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40530/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPhilipNSuffys_HarrisonGomes_etal_IOC_2019.pdfPhilipNSuffys_HarrisonGomes_etal_IOC_2019.pdfapplication/pdf1698056https://www.arca.fiocruz.br/bitstream/icict/40530/2/PhilipNSuffys_HarrisonGomes_etal_IOC_2019.pdf5e736975d1ecd4bad2cdc6f2ebcc2946MD52TEXTPhilipNSuffys_HarrisonGomes_etal_IOC_2019.pdf.txtPhilipNSuffys_HarrisonGomes_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| title |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| spellingShingle |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection Eyer-Silva, Walter de Araujo AIDS Mycobacterium haemophilum Infecção pelo HIV Síndrome Inflamatória de Reconstituição Imunológica Mycobacterium não tuberculoso AIDS HIV infection Immune Reconstitution Inflammatory Syndrome Mycobacterium haemophilum Nontuberculous mycobacterium |
| title_short |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| title_full |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| title_fullStr |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| title_full_unstemmed |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| title_sort |
Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection |
| author |
Eyer-Silva, Walter de Araujo |
| author_facet |
Eyer-Silva, Walter de Araujo Almeida, Marina Rodrigues de Martins, Carlos José Oliveira, Rodrigo Panno Basílio de Araujo, Luciana Ferreira de Oliveira, Carlos Alberto Basílio de Azevedo, Marcelo Costa Velho Mendes de Pinto, Jorge Francisco da Cunha Vasconcellos, Sidra Ezidio Gonçalves Santos, Ícaro Rodrigues Dos Gomes, Harrison Magdinier Suffys, Philip Noel |
| author_role |
author |
| author2 |
Almeida, Marina Rodrigues de Martins, Carlos José Oliveira, Rodrigo Panno Basílio de Araujo, Luciana Ferreira de Oliveira, Carlos Alberto Basílio de Azevedo, Marcelo Costa Velho Mendes de Pinto, Jorge Francisco da Cunha Vasconcellos, Sidra Ezidio Gonçalves Santos, Ícaro Rodrigues Dos Gomes, Harrison Magdinier Suffys, Philip Noel |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Eyer-Silva, Walter de Araujo Almeida, Marina Rodrigues de Martins, Carlos José Oliveira, Rodrigo Panno Basílio de Araujo, Luciana Ferreira de Oliveira, Carlos Alberto Basílio de Azevedo, Marcelo Costa Velho Mendes de Pinto, Jorge Francisco da Cunha Vasconcellos, Sidra Ezidio Gonçalves Santos, Ícaro Rodrigues Dos Gomes, Harrison Magdinier Suffys, Philip Noel |
| dc.subject.other.pt_BR.fl_str_mv |
AIDS Mycobacterium haemophilum Infecção pelo HIV Síndrome Inflamatória de Reconstituição Imunológica Mycobacterium não tuberculoso |
| topic |
AIDS Mycobacterium haemophilum Infecção pelo HIV Síndrome Inflamatória de Reconstituição Imunológica Mycobacterium não tuberculoso AIDS HIV infection Immune Reconstitution Inflammatory Syndrome Mycobacterium haemophilum Nontuberculous mycobacterium |
| dc.subject.en.pt_BR.fl_str_mv |
AIDS HIV infection Immune Reconstitution Inflammatory Syndrome Mycobacterium haemophilum Nontuberculous mycobacterium |
| description |
Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Centro de Ciências Biológicas e da Saúde. Rio de Janeiro, RJ, Brasil. |
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2019 |
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2019 |
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2020-03-26T20:58:16Z |
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2020-03-26T20:58:16Z |
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EYER-SILVA, Walter de Araujo et al. Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 61, p. 1-6, Nov. 2019. |
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https://www.arca.fiocruz.br/handle/icict/40530 |
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0036-4665 |
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10.1590/S1678-9946201961071 |
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1678-9946 |
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EYER-SILVA, Walter de Araujo et al. Antiretroviral therapy-induced paradoxical worsening of previously healed Mycobacterium haemophilum cutaneous lesions in advanced HIV infection. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 61, p. 1-6, Nov. 2019. 0036-4665 10.1590/S1678-9946201961071 1678-9946 |
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Universidade de São Paulo |
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Universidade de São Paulo |
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