Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11487 |
Resumo: | Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany. |
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Nussbaum, ClaudiaBannenberg, SarahKeul, PetraGräler, Markus H.Albuquerque, Cassiano F. Gonçalves deKorhonen, HannaLipinski, Karin von WnuckHeusch, GerdFaria Neto, Hugo C. de CastroRohwedder, InaGöther, Joachim R.Prasad, Vysakh PushpaHaufe, GünterLange-Sperandio, BaerbelOffermanns, StefanSperandio, MarkusLevkau, Bodo2015-08-19T13:49:20Z2015-08-19T13:49:20Z2015NUSSBAUM, Claudia; et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6:6416, 12p, 2015.2041-1723https://www.arca.fiocruz.br/handle/icict/1148710.1038/ncomms7416engMacmillan Publishers LimitedSphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLudwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.University Hospital Jena. Center for Molecular Biomedicine.Center for Sepsis Control and Care. Department of Anesthesiology and Intensive Care Medicine. Jena, Germany.Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany.University of Duisburg-Essen.University Hospital Essen. Department of Hematology. Essen, Germany.Westfälische Wilhelms-Universität Münster. Organisch-Chemisches Institut. Münster, Germany.Westfälische Wilhelms-Universität Münster. Organisch-Chemisches Institut. Münster, Germany.Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany.Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P3) and Gαq, PLCβ and Ca(2+). Intra-arterial S1P administration increases leukocyte rolling, while S1P3 deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P3. Histamine and epinephrine require S1P3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P1(-/-) mice. In agreement with a dominant pro-rolling effect of S1P3, FTY720 inhibits rolling in control and S1P1(-/-) but not in S1P3(-/-) mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action.Endothelial P-selectinSphingosine-1-phosphateLeukocyteSelectina-PPsicosinaLeucócitosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11487/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALhugo_farianeto_etal_IOC_2015.pdfapplication/pdf1192166https://www.arca.fiocruz.br/bitstream/icict/11487/2/hugo_farianeto_etal_IOC_2015.pdfeb61819d2e63cfa1e06be0a5935a3cd3MD52TEXThugo_farianeto_etal_IOC_2015.pdf.txthugo_farianeto_etal_IOC_2015.pdf.txtExtracted texttext/plain76718https://www.arca.fiocruz.br/bitstream/icict/11487/3/hugo_farianeto_etal_IOC_2015.pdf.txt92596527116aa43277f850e7358798adMD53icict/114872022-06-24 13:08:52.918oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
title |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
spellingShingle |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin Nussbaum, Claudia Endothelial P-selectin Sphingosine-1-phosphate Leukocyte Selectina-P Psicosina Leucócitos |
title_short |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
title_full |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
title_fullStr |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
title_full_unstemmed |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
title_sort |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin |
author |
Nussbaum, Claudia |
author_facet |
Nussbaum, Claudia Bannenberg, Sarah Keul, Petra Gräler, Markus H. Albuquerque, Cassiano F. Gonçalves de Korhonen, Hanna Lipinski, Karin von Wnuck Heusch, Gerd Faria Neto, Hugo C. de Castro Rohwedder, Ina Göther, Joachim R. Prasad, Vysakh Pushpa Haufe, Günter Lange-Sperandio, Baerbel Offermanns, Stefan Sperandio, Markus Levkau, Bodo |
author_role |
author |
author2 |
Bannenberg, Sarah Keul, Petra Gräler, Markus H. Albuquerque, Cassiano F. Gonçalves de Korhonen, Hanna Lipinski, Karin von Wnuck Heusch, Gerd Faria Neto, Hugo C. de Castro Rohwedder, Ina Göther, Joachim R. Prasad, Vysakh Pushpa Haufe, Günter Lange-Sperandio, Baerbel Offermanns, Stefan Sperandio, Markus Levkau, Bodo |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nussbaum, Claudia Bannenberg, Sarah Keul, Petra Gräler, Markus H. Albuquerque, Cassiano F. Gonçalves de Korhonen, Hanna Lipinski, Karin von Wnuck Heusch, Gerd Faria Neto, Hugo C. de Castro Rohwedder, Ina Göther, Joachim R. Prasad, Vysakh Pushpa Haufe, Günter Lange-Sperandio, Baerbel Offermanns, Stefan Sperandio, Markus Levkau, Bodo |
dc.subject.en.pt_BR.fl_str_mv |
Endothelial P-selectin Sphingosine-1-phosphate Leukocyte |
topic |
Endothelial P-selectin Sphingosine-1-phosphate Leukocyte Selectina-P Psicosina Leucócitos |
dc.subject.decs.pt_BR.fl_str_mv |
Selectina-P Psicosina Leucócitos |
description |
Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-08-19T13:49:20Z |
dc.date.available.fl_str_mv |
2015-08-19T13:49:20Z |
dc.date.issued.fl_str_mv |
2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NUSSBAUM, Claudia; et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6:6416, 12p, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/11487 |
dc.identifier.issn.pt_BR.fl_str_mv |
2041-1723 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1038/ncomms7416 |
identifier_str_mv |
NUSSBAUM, Claudia; et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6:6416, 12p, 2015. 2041-1723 10.1038/ncomms7416 |
url |
https://www.arca.fiocruz.br/handle/icict/11487 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Macmillan Publishers Limited |
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Macmillan Publishers Limited |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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