Type 1 and type 2 responses to Leishmania major

Detalhes bibliográficos
Autor(a) principal: Rogers, Kathleen A
Data de Publicação: 2002
Outros Autores: DeKrey, Gregory K, Mbow, M. Lamine, Gillespie, R. Dean, Brodskyn, Claudia Ida, Titus, Richard G
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8402
Resumo: University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
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spelling Rogers, Kathleen ADeKrey, Gregory KMbow, M. LamineGillespie, R. DeanBrodskyn, Claudia IdaTitus, Richard G2014-09-19T13:16:20Z2014-09-19T13:16:20Z2002ROGERS, K. A. et al. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters, v. 209, n. 1, p. 1-7, 2002.0378-1097https://www.arca.fiocruz.br/handle/icict/8402engElsevier Science B.VType 1 and type 2 responses to Leishmania majorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Northern Colorado. Department of Biological Sciences. Greeley, ColoradoUniversity of Northern Colorado. Department of Biological Sciences. Greeley, ColoradoBiopharmaceutical Research, Centocor. Malvern, PA, USAColorado State University. College of Veterinary Medicine and Biomedical Sciences. Department of Microbiology, Immunology and Pathology. CO, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversity of Northern Colorado. Department of Biological Sciences. Greeley, ColoradoLeishmania major is a protozoan parasite that is transmitted to the mammalian host by its sand fly vector when the fly probes in the host's skin for a blood meal and injects the parasite within its saliva. In mice experimentally infected with L. major, outgrowth of CD4 type 1 (Th1) cells leads to resolution of the infection, but outgrowth of type 2 (Th2) cells exacerbates disease. To design an effective vaccine against the parasite (and other pathogens that induce polarized Th1 and Th2 responses), we must determine the mechanism underlying this phenomenon so that we can design the vaccine to elicit the appropriate (i.e., protective) Th cell. Recent work indicates that Th bias is influenced by a number of signals delivered by antigen-presenting cells, including cytokines and co-stimulatory molecules. Moreover, recent work also suggests that sand fly saliva influences the immune response to L. major and Th polarization. Determining the mechanisms that lead to polarized Th responses should expand our knowledge regarding immunity to L. major, and should add to our understanding of immunoregulation in generalLeishmaniasisTh cellAntigen-presenting cellCytokineCo-stimulationSand flyLeishmania major/imunologiaLeishmaniose Cutânea/imunologiaCélulas Th1/imunologiaAnimaisApresentação do AntígenoAntígenos CD/imunologiaSuscetibilidade a DoençasPrevisõesHumanosProteínas de Insetos/imunologiaInsetos Vetores/parasitologiaLeishmaniose Cutânea/transmissãoAtivação LinfocitáriaCamundongosCamundongos EndogâmicosVacinas Protozoárias/imunologiaPsychodidae/imunologiaSaliva/parasitologiaProteínas e Peptídeos Salivares/imunologiaCélulas Th1/secreçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8402/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALRogers KA Type 1 and type 2 responses......pdfRogers KA Type 1 and type 2 responses......pdfapplication/pdf237285https://www.arca.fiocruz.br/bitstream/icict/8402/2/Rogers%20KA%20Type%201%20and%20type%202%20responses......pdf3b8be1b4d6b674dc217267b659ded0a8MD52TEXTRogers KA Type 1 and type 2 responses......pdf.txtRogers KA Type 1 and type 2 responses......pdf.txtExtracted texttext/plain36838https://www.arca.fiocruz.br/bitstream/icict/8402/3/Rogers%20KA%20Type%201%20and%20type%202%20responses......pdf.txtfbcede14b902018c7435a6265d80c739MD53icict/84022023-03-15 14:33:15.885oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Type 1 and type 2 responses to Leishmania major
title Type 1 and type 2 responses to Leishmania major
spellingShingle Type 1 and type 2 responses to Leishmania major
Rogers, Kathleen A
Leishmaniasis
Th cell
Antigen-presenting cell
Cytokine
Co-stimulation
Sand fly
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Células Th1/imunologia
Animais
Apresentação do Antígeno
Antígenos CD/imunologia
Suscetibilidade a Doenças
Previsões
Humanos
Proteínas de Insetos/imunologia
Insetos Vetores/parasitologia
Leishmaniose Cutânea/transmissão
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos
Vacinas Protozoárias/imunologia
Psychodidae/imunologia
Saliva/parasitologia
Proteínas e Peptídeos Salivares/imunologia
Células Th1/secreção
title_short Type 1 and type 2 responses to Leishmania major
title_full Type 1 and type 2 responses to Leishmania major
title_fullStr Type 1 and type 2 responses to Leishmania major
title_full_unstemmed Type 1 and type 2 responses to Leishmania major
title_sort Type 1 and type 2 responses to Leishmania major
author Rogers, Kathleen A
author_facet Rogers, Kathleen A
DeKrey, Gregory K
Mbow, M. Lamine
Gillespie, R. Dean
Brodskyn, Claudia Ida
Titus, Richard G
author_role author
author2 DeKrey, Gregory K
Mbow, M. Lamine
Gillespie, R. Dean
Brodskyn, Claudia Ida
Titus, Richard G
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rogers, Kathleen A
DeKrey, Gregory K
Mbow, M. Lamine
Gillespie, R. Dean
Brodskyn, Claudia Ida
Titus, Richard G
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Th cell
Antigen-presenting cell
Cytokine
Co-stimulation
Sand fly
topic Leishmaniasis
Th cell
Antigen-presenting cell
Cytokine
Co-stimulation
Sand fly
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Células Th1/imunologia
Animais
Apresentação do Antígeno
Antígenos CD/imunologia
Suscetibilidade a Doenças
Previsões
Humanos
Proteínas de Insetos/imunologia
Insetos Vetores/parasitologia
Leishmaniose Cutânea/transmissão
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos
Vacinas Protozoárias/imunologia
Psychodidae/imunologia
Saliva/parasitologia
Proteínas e Peptídeos Salivares/imunologia
Células Th1/secreção
dc.subject.decs.pt_BR.fl_str_mv Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Células Th1/imunologia
Animais
Apresentação do Antígeno
Antígenos CD/imunologia
Suscetibilidade a Doenças
Previsões
Humanos
Proteínas de Insetos/imunologia
Insetos Vetores/parasitologia
Leishmaniose Cutânea/transmissão
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos
Vacinas Protozoárias/imunologia
Psychodidae/imunologia
Saliva/parasitologia
Proteínas e Peptídeos Salivares/imunologia
Células Th1/secreção
description University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2014-09-19T13:16:20Z
dc.date.available.fl_str_mv 2014-09-19T13:16:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROGERS, K. A. et al. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters, v. 209, n. 1, p. 1-7, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8402
dc.identifier.issn.none.fl_str_mv 0378-1097
identifier_str_mv ROGERS, K. A. et al. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters, v. 209, n. 1, p. 1-7, 2002.
0378-1097
url https://www.arca.fiocruz.br/handle/icict/8402
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Science B.V
publisher.none.fl_str_mv Elsevier Science B.V
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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