Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10675 |
Resumo: | CNRS UMR8147, Paris Descartes University, Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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Cruz, Daniella Arêas Mendes daBrignier, Anne ColetteAsnafi, VahidBeleydier, FredericMessias, Carolina ValençaLepelletier, YvesBedjaoui, NawelRenand, AmedéeSmaniotto, SaleteCanloni, DanielleMilpied, PierreBalabanian, KarlBousso, PhillippeLeprétre, StéphaneBertrand, YvesDombret, HervéIfrah, NorbertDardenne, MireilleMacintyre, ElizabethSavino, WilsonHermine, Olivier2015-06-08T14:01:46Z2015-06-08T14:01:46Z2014CRUZ, Daniella Arêas Mendes da; et al. Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors. Plos One, v.9, n.7, 7p, 2014.https://www.arca.fiocruz.br/handle/icict/1067510.1371/journal.pone.0103405engPlos OneSemaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCNRS UMR8147, Paris Descartes University, Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.CNRS UMR8147, Paris Descartes University, Paris, France / Assistance Publique-Hôpitaux de Paris (AP-HP). Necker Children’s Hospital. Department of Clinical Hematology. Paris, France.Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France.Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.CNRS UMR8147, Paris Descartes University, Paris, France / Imagine Institute. INSERM U1163, CNRS ERL 8254, Laboratory of cellular and molecular basis of hematological disorders and their therapeutic implications. Paris, France.Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France.CNRS UMR8147, Paris Descartes University, Paris, France.Universidade Federal de Alagoas. Departamento de Morfologia. Macei[o, AL, Brasil.Universidade Federal de Alagoas. Departamento de Morfologia. Macei[o, AL, Brasil /Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France.CNRS UMR8147, Paris Descartes University, Paris, France.INSERM U819 – Pasteur Institute, Paris, France.INSERM U668 – Pasteur Institute. Paris, France.Centre Henri Becquerel. Department of Hematology. Rouen, France.Hôpital Debrousse. Service of Pediatric Hematology. Lyon, France.University Paris 7, Hôpital Saint-Louis, AP-HP. Institut Universitaire d’He´matologie EA3518. Paris, France.Pôle de Recherche et d’Enseignement Supérieur l’Université Nantes Angers Le Mans. Centre Hospitalier Universitaire Angers. Service des Maladies du Sang and INSERM U892. Angers, FranceCNRS UMR8147, Paris Descartes University, Paris, France.Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.CNRS UMR8147, Paris Descartes University, Paris, France / Necker Children’s Hospital. Laboratory of Oncohematology, AP-HP. Paris, France /Imagine Institute. INSERM U1163, CNRS ERL 8254, Laboratory of cellular and molecular basis of hematological disorders and their therapeutic implications. Paris, France.Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.ThymusNeuropillinsSemaphorinsLymphomaLeukemiaHuman T-Cell PrecursorsNeuropilinasSemaforinasLeucemiaLinfomainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10675/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALdaniella_cruzetal_IOC_2014.pdfapplication/pdf1358849https://www.arca.fiocruz.br/bitstream/icict/10675/2/daniella_cruzetal_IOC_2014.pdfb10c056fbfdecae38660c635bc8bdd1cMD52TEXTdaniella_cruzetal_IOC_2014.pdf.txtdaniella_cruzetal_IOC_2014.pdf.txtExtracted texttext/plain37949https://www.arca.fiocruz.br/bitstream/icict/10675/3/daniella_cruzetal_IOC_2014.pdf.txt4bcba735f959172d6e903fbff738091cMD53icict/106752022-06-24 13:02:53.102oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| title |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| spellingShingle |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors Cruz, Daniella Arêas Mendes da Thymus Neuropillins Semaphorins Lymphoma Leukemia Human T-Cell Precursors Neuropilinas Semaforinas Leucemia Linfoma |
| title_short |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| title_full |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| title_fullStr |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| title_full_unstemmed |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| title_sort |
Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors |
| author |
Cruz, Daniella Arêas Mendes da |
| author_facet |
Cruz, Daniella Arêas Mendes da Brignier, Anne Colette Asnafi, Vahid Beleydier, Frederic Messias, Carolina Valença Lepelletier, Yves Bedjaoui, Nawel Renand, Amedée Smaniotto, Salete Canloni, Danielle Milpied, Pierre Balabanian, Karl Bousso, Phillippe Leprétre, Stéphane Bertrand, Yves Dombret, Hervé Ifrah, Norbert Dardenne, Mireille Macintyre, Elizabeth Savino, Wilson Hermine, Olivier |
| author_role |
author |
| author2 |
Brignier, Anne Colette Asnafi, Vahid Beleydier, Frederic Messias, Carolina Valença Lepelletier, Yves Bedjaoui, Nawel Renand, Amedée Smaniotto, Salete Canloni, Danielle Milpied, Pierre Balabanian, Karl Bousso, Phillippe Leprétre, Stéphane Bertrand, Yves Dombret, Hervé Ifrah, Norbert Dardenne, Mireille Macintyre, Elizabeth Savino, Wilson Hermine, Olivier |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cruz, Daniella Arêas Mendes da Brignier, Anne Colette Asnafi, Vahid Beleydier, Frederic Messias, Carolina Valença Lepelletier, Yves Bedjaoui, Nawel Renand, Amedée Smaniotto, Salete Canloni, Danielle Milpied, Pierre Balabanian, Karl Bousso, Phillippe Leprétre, Stéphane Bertrand, Yves Dombret, Hervé Ifrah, Norbert Dardenne, Mireille Macintyre, Elizabeth Savino, Wilson Hermine, Olivier |
| dc.subject.en.pt_BR.fl_str_mv |
Thymus Neuropillins Semaphorins Lymphoma Leukemia Human T-Cell Precursors |
| topic |
Thymus Neuropillins Semaphorins Lymphoma Leukemia Human T-Cell Precursors Neuropilinas Semaforinas Leucemia Linfoma |
| dc.subject.decs.pt_BR.fl_str_mv |
Neuropilinas Semaforinas Leucemia Linfoma |
| description |
CNRS UMR8147, Paris Descartes University, Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2015-06-08T14:01:46Z |
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2015-06-08T14:01:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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CRUZ, Daniella Arêas Mendes da; et al. Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors. Plos One, v.9, n.7, 7p, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10675 |
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10.1371/journal.pone.0103405 |
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CRUZ, Daniella Arêas Mendes da; et al. Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors. Plos One, v.9, n.7, 7p, 2014. 10.1371/journal.pone.0103405 |
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Plos One |
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