Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19

Detalhes bibliográficos
Autor(a) principal: Oliveira, Jéssica Araujo da Paixão de
Data de Publicação: 2022
Outros Autores: Athaide, Mariana Martins de, Rahman, Atta Ur, Barbosa, Mayara Garcia de Mattos, Jardim, Marcia Maria, Moraes, Milton Ozório, Pinheiro, Roberta Olmo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54594
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
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repository_id_str 2135
spelling Oliveira, Jéssica Araujo da Paixão deAthaide, Mariana Martins deRahman, Atta UrBarbosa, Mayara Garcia de MattosJardim, Marcia MariaMoraes, Milton OzórioPinheiro, Roberta Olmo2022-08-11T14:17:11Z2022-08-11T14:17:11Z2022OLIVEIRA, Jéssica Araujo da Paixão de; et al. Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19. Frontiers in Cellular and Infection Microbiology, v. 12, Article 15738, p. 1 - 16, Feb. 2022.2235-2988https://www.arca.fiocruz.br/handle/icict/5459410.3389/fcimb.2022.815738engFrontiers MediaVia das quinureninasNeuropatia periféricaHanseníaseCOVID-19TriptofanoKynurenine pathwayPeripheral neuropathyLeprosyCOVID-19TryptophanKynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Department of Surgery, University of Michigan. Ann Arbor, MI, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro,; Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both Mycobacterium leprae and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. In recent years KP has received greater attention due the importance of kynurenine metabolites in infectious diseases, immune dysfunction and nervous system disorders. In this review, we discuss how modulation of the KP may aid in controlling the damage to peripheral nerves and the effects of KP activation on neural damage during leprosy or COVID-19 individually and we speculate its role during co-infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54594/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJessicaOliveira_AttaUrRahman_etal_IOC_2022.pdfJessicaOliveira_AttaUrRahman_etal_IOC_2022.pdfapplication/pdf2498303https://www.arca.fiocruz.br/bitstream/icict/54594/2/JessicaOliveira_AttaUrRahman_etal_IOC_2022.pdf467352b41c2aca9e400a97b738d265c0MD52icict/545942022-08-11 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dc.title.pt_BR.fl_str_mv Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
spellingShingle Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
Oliveira, Jéssica Araujo da Paixão de
Via das quinureninas
Neuropatia periférica
Hanseníase
COVID-19
Triptofano
Kynurenine pathway
Peripheral neuropathy
Leprosy
COVID-19
Tryptophan
title_short Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_full Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_fullStr Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_full_unstemmed Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_sort Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
author Oliveira, Jéssica Araujo da Paixão de
author_facet Oliveira, Jéssica Araujo da Paixão de
Athaide, Mariana Martins de
Rahman, Atta Ur
Barbosa, Mayara Garcia de Mattos
Jardim, Marcia Maria
Moraes, Milton Ozório
Pinheiro, Roberta Olmo
author_role author
author2 Athaide, Mariana Martins de
Rahman, Atta Ur
Barbosa, Mayara Garcia de Mattos
Jardim, Marcia Maria
Moraes, Milton Ozório
Pinheiro, Roberta Olmo
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Jéssica Araujo da Paixão de
Athaide, Mariana Martins de
Rahman, Atta Ur
Barbosa, Mayara Garcia de Mattos
Jardim, Marcia Maria
Moraes, Milton Ozório
Pinheiro, Roberta Olmo
dc.subject.other.pt_BR.fl_str_mv Via das quinureninas
Neuropatia periférica
Hanseníase
COVID-19
Triptofano
topic Via das quinureninas
Neuropatia periférica
Hanseníase
COVID-19
Triptofano
Kynurenine pathway
Peripheral neuropathy
Leprosy
COVID-19
Tryptophan
dc.subject.en.pt_BR.fl_str_mv Kynurenine pathway
Peripheral neuropathy
Leprosy
COVID-19
Tryptophan
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-08-11T14:17:11Z
dc.date.available.fl_str_mv 2022-08-11T14:17:11Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Jéssica Araujo da Paixão de; et al. Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19. Frontiers in Cellular and Infection Microbiology, v. 12, Article 15738, p. 1 - 16, Feb. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54594
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2022.815738
identifier_str_mv OLIVEIRA, Jéssica Araujo da Paixão de; et al. Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19. Frontiers in Cellular and Infection Microbiology, v. 12, Article 15738, p. 1 - 16, Feb. 2022.
2235-2988
10.3389/fcimb.2022.815738
url https://www.arca.fiocruz.br/handle/icict/54594
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54594/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/54594/2/JessicaOliveira_AttaUrRahman_etal_IOC_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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