Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area

Detalhes bibliográficos
Autor(a) principal: Batista, Raquel Pereira
Data de Publicação: 2023
Outros Autores: Hökerberg, Yara Hahr Marques, Oliveira, Raquel de Vasconcellos Carvalhaes de, Passos, Sonia Regina Lambert
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57440
Resumo: This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. URL: https://www.gov.br/capes/pt-br. YHMH was supported by Estácio de Sá University (Pesquisa Produtividade); SRLP was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico – CNPq (310765/2016-1). The funders had no role in study design, data collection and analysis or preparation of the manuscript.
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spelling Batista, Raquel PereiraHökerberg, Yara Hahr MarquesOliveira, Raquel de Vasconcellos Carvalhaes dePassos, Sonia Regina Lambert2023-03-18T02:07:10Z2023-03-18T02:07:10Z2023BATISTA, Raquel Pereira et al. Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area. Plos One, v. 18, n. 1, p. 1-13, Jan. 6, 2023.1932-6203https://www.arca.fiocruz.br/handle/icict/5744010.1371/journal.pone.0279970This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. URL: https://www.gov.br/capes/pt-br. YHMH was supported by Estácio de Sá University (Pesquisa Produtividade); SRLP was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico – CNPq (310765/2016-1). The funders had no role in study design, data collection and analysis or preparation of the manuscript.Fundação Oswaldo Cruz. Escola Nacional de Saúde Publica Sergio Arouca. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clinica. Rio de Janeiro, RJ, Brazil / Universidade Estácio de Sá. Faculdade de Medicina. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clinica. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia Clinica. Rio de Janeiro, RJ, Brazil.Rio de Janeiro is a dengue-endemic city that experienced Zika and chikungunya epidemics between 2015 and 2019. Differential diagnosis is crucial for indicating adequate treatment and assessing prognosis and risk of death. This study aims to derive and validate a clinical rule for diagnosing chikungunya based on 3,214 suspected cases consecutively treated at primary and secondary health units of the sentinel surveillance system (up to 7 days from onset of symptoms) in Rio de Janeiro, Brazil. Of the total sample, 624 were chikungunya, 88 Zika, 51 dengue, and 2,451 were negative for all these arboviruses according to real-time polymerase chain reaction (RT-qPCR). The derived rule included fever (1 point), exanthema (1 point), myalgia (2 points), arthralgia or arthritis (2 points), and joint edema (2 points), providing an AUC (area under the receiver operator curve) = 0.695 (95% CI: 0.662-0.725). Scores of 4 points or more (validation sample) showed 74.3% sensitivity (69.0% - 79.2%) and 51.5% specificity (48.8% - 54.3%). Adding more symptoms improved the specificity at the expense of a lower sensitivity compared to definitions proposed by government agencies based on fever alone (European Center for Disease Control) or in combination with arthralgia (World Health Organization) or arthritis (Pan American Health Organization, Brazilian Ministry of Health). The proposed clinical rule offers a rapid, low-cost, easy-to-apply strategy to differentiate chikungunya fever from other arbovirus infections during epidemics.engMDPIDevelopment and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic areainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleChikungunya feverChikungunyaChikungunya virusZika virusEpidemicNeglected arbovirus infectioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57440/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Batista_Raquel_etal_ENSP_INI_2023.pdfve_Batista_Raquel_etal_ENSP_INI_2023.pdfapplication/pdf1457288https://www.arca.fiocruz.br/bitstream/icict/57440/2/ve_Batista_Raquel_etal_ENSP_INI_2023.pdf462942b0163928da73654099a8c041d2MD52icict/574402023-04-11 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dc.title.en_US.fl_str_mv Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
title Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
spellingShingle Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
Batista, Raquel Pereira
Chikungunya fever
Chikungunya
Chikungunya virus
Zika virus
Epidemic
Neglected arbovirus infection
title_short Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
title_full Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
title_fullStr Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
title_full_unstemmed Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
title_sort Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area
author Batista, Raquel Pereira
author_facet Batista, Raquel Pereira
Hökerberg, Yara Hahr Marques
Oliveira, Raquel de Vasconcellos Carvalhaes de
Passos, Sonia Regina Lambert
author_role author
author2 Hökerberg, Yara Hahr Marques
Oliveira, Raquel de Vasconcellos Carvalhaes de
Passos, Sonia Regina Lambert
author2_role author
author
author
dc.contributor.author.fl_str_mv Batista, Raquel Pereira
Hökerberg, Yara Hahr Marques
Oliveira, Raquel de Vasconcellos Carvalhaes de
Passos, Sonia Regina Lambert
dc.subject.en.en_US.fl_str_mv Chikungunya fever
Chikungunya
Chikungunya virus
Zika virus
Epidemic
Neglected arbovirus infection
topic Chikungunya fever
Chikungunya
Chikungunya virus
Zika virus
Epidemic
Neglected arbovirus infection
description This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001. URL: https://www.gov.br/capes/pt-br. YHMH was supported by Estácio de Sá University (Pesquisa Produtividade); SRLP was supported by Conselho Nacional de Desenvolvimento Cientifico e Tecnológico – CNPq (310765/2016-1). The funders had no role in study design, data collection and analysis or preparation of the manuscript.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-18T02:07:10Z
dc.date.available.fl_str_mv 2023-03-18T02:07:10Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BATISTA, Raquel Pereira et al. Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area. Plos One, v. 18, n. 1, p. 1-13, Jan. 6, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57440
dc.identifier.issn.en_US.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0279970
identifier_str_mv BATISTA, Raquel Pereira et al. Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area. Plos One, v. 18, n. 1, p. 1-13, Jan. 6, 2023.
1932-6203
10.1371/journal.pone.0279970
url https://www.arca.fiocruz.br/handle/icict/57440
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57440/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57440/2/ve_Batista_Raquel_etal_ENSP_INI_2023.pdf
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