Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1155/2012/132049 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18383 |
Resumo: | LUMC. Department of Infectious Diseases. Leiden, The Netherlands / Armauer Hansen Research Institute. Leprosy Section. Addis Ababa, Ethiopia. |
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Bobosha, Kidistvan der Ploeg-van Schip, Jolien J.Esquenazi, Danuza A.Guimarães, Marjorie M.Martins, Marcia V.Bekele, YonasFantahun, YonasAseffa, AbrahamFranken, Kees L. M. C.Gismondi, Ronaldo C.Pessolani, Maria C. V.Ottenhoff, Tom H. M.Pereira, Geraldo M. B.Geluk, Annemieke2017-04-11T17:08:07Z2017-04-11T17:08:07Z2012BOBOSHA, Kidist; et al. Peptides Derived fromMycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls. Journal of Tropical Medicine, Volume 2012, Article ID132049, 11p, 2012.1687-9686https://www.arca.fiocruz.br/handle/icict/1838310.1155/2012/1320491687-9694engHindawi Publishing CorporationMycobacterium lepraePeptídeosHanseníaseControles endêmicosMycobacterium lepraePeptidesLeprosyEndemic ControlsPeptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controlsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLUMC. Department of Infectious Diseases. Leiden, The Netherlands / Armauer Hansen Research Institute. Leprosy Section. Addis Ababa, Ethiopia.LUMC. Department of Infectious Diseases. Leiden, The NetherlandsFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil / Universidade do Estado do rio de Janeiro. Escola de Ciências Médicas. Rio de Janeiro, RJ, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. BrasilArmauer Hansen Research Institute. Leprosy Section. Addis Ababa, Ethiopia.Armauer Hansen Research Institute. Leprosy Section. Addis Ababa, Ethiopia.Armauer Hansen Research Institute. Leprosy Section. Addis Ababa, Ethiopia.LUMC. Department of Infectious Diseases. Leiden, The NetherlandsUniversidade do Estado do Rio de Janeiro. Escola de Ciências Médicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil.LUMC. Department of Infectious Diseases. Leiden, The Netherlands.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ. Brasil / Universidade do Estado do rio de Janeiro. Escola de Ciências Médicas. Rio de Janeiro, RJ, Brasil..LUMC. Department of Infectious Diseases. Leiden, The Netherlands.The stable incidence of new leprosy cases suggests that transmission of infection continues despite worldwide implementation of MDT. Thus, specific tools are needed to diagnose early stage Mycobacterium leprae infection, the likely sources of transmission. M. leprae antigens that induce T-cell responses in M. leprae exposed and/or infected individuals thus are major targets for new diagnostic tools. Previously, we showed that ML1601c was immunogenic in patients and healthy household contacts (HHC). However, some endemic controls (EC) also recognized this protein. To improve the diagnostic potential, IFN-γ responses to ML1601c peptides were assessed using PBMC from Brazilian leprosy patients and EC. Five ML1601c peptides only induced IFN-γ in patients and HHC. Moreover, 24-hour whole-blood assay (WBA), two ML1601c peptides could assess the level of M. leprae exposure in Ethiopian EC. Beside IFN-γ, also IP-10, IL-6, IL-1β, TNF-α, and MCP-1 were increased in EC from areas with high leprosy prevalence in response to these ML1601c peptides. Thus, ML1601c peptides may be useful for differentiating M. leprae exposed or infected individuals and can also be used to indicate the magnitude of M. leprae transmission even in the context of various HLA alleles as present in these different genetic backgrounds.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18383/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmaria4_pessoalani_etal_IOC_2012.pdfmaria4_pessoalani_etal_IOC_2012.pdfapplication/pdf2769437https://www.arca.fiocruz.br/bitstream/icict/18383/2/maria4_pessoalani_etal_IOC_2012.pdf8cef895a7d5629984574ee0bb969e970MD52TEXTmaria4_pessoalani_etal_IOC_2012.pdf.txtmaria4_pessoalani_etal_IOC_2012.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| title |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| spellingShingle |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls Bobosha, Kidist Mycobacterium leprae Peptídeos Hanseníase Controles endêmicos Mycobacterium leprae Peptides Leprosy Endemic Controls |
| title_short |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| title_full |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| title_fullStr |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| title_full_unstemmed |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| title_sort |
Peptides Derived from Mycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls |
| author |
Bobosha, Kidist |
| author_facet |
Bobosha, Kidist van der Ploeg-van Schip, Jolien J. Esquenazi, Danuza A. Guimarães, Marjorie M. Martins, Marcia V. Bekele, Yonas Fantahun, Yonas Aseffa, Abraham Franken, Kees L. M. C. Gismondi, Ronaldo C. Pessolani, Maria C. V. Ottenhoff, Tom H. M. Pereira, Geraldo M. B. Geluk, Annemieke |
| author_role |
author |
| author2 |
van der Ploeg-van Schip, Jolien J. Esquenazi, Danuza A. Guimarães, Marjorie M. Martins, Marcia V. Bekele, Yonas Fantahun, Yonas Aseffa, Abraham Franken, Kees L. M. C. Gismondi, Ronaldo C. Pessolani, Maria C. V. Ottenhoff, Tom H. M. Pereira, Geraldo M. B. Geluk, Annemieke |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bobosha, Kidist van der Ploeg-van Schip, Jolien J. Esquenazi, Danuza A. Guimarães, Marjorie M. Martins, Marcia V. Bekele, Yonas Fantahun, Yonas Aseffa, Abraham Franken, Kees L. M. C. Gismondi, Ronaldo C. Pessolani, Maria C. V. Ottenhoff, Tom H. M. Pereira, Geraldo M. B. Geluk, Annemieke |
| dc.subject.other.pt_BR.fl_str_mv |
Mycobacterium leprae Peptídeos Hanseníase Controles endêmicos |
| topic |
Mycobacterium leprae Peptídeos Hanseníase Controles endêmicos Mycobacterium leprae Peptides Leprosy Endemic Controls |
| dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium leprae Peptides Leprosy Endemic Controls |
| description |
LUMC. Department of Infectious Diseases. Leiden, The Netherlands / Armauer Hansen Research Institute. Leprosy Section. Addis Ababa, Ethiopia. |
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2012 |
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2012 |
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2017-04-11T17:08:07Z |
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2017-04-11T17:08:07Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BOBOSHA, Kidist; et al. Peptides Derived fromMycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls. Journal of Tropical Medicine, Volume 2012, Article ID132049, 11p, 2012. |
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https://www.arca.fiocruz.br/handle/icict/18383 |
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1687-9686 |
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10.1155/2012/132049 |
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1687-9694 |
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BOBOSHA, Kidist; et al. Peptides Derived fromMycobacterium leprae ML1601c Discriminate between Leprosy Patients and Healthy Endemic Controls. Journal of Tropical Medicine, Volume 2012, Article ID132049, 11p, 2012. 1687-9686 10.1155/2012/132049 1687-9694 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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