Distribution of the CCR2-64I allele in three Brazilian ethnic groups

Detalhes bibliográficos
Autor(a) principal: Acosta,Angelina Xavier
Data de Publicação: 2003
Outros Autores: Sampaio,Rogério Grimaldi, Spínola,Juliana Lima, Galvão-Castro,Bernardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300004
Resumo: CCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó tribe); 89 German descendents from Joinville, a city in southern Brazil; and 305 individuals of predominantly African ancestry, from Salvador, a city in northeast Brazil. The CCR2-64I mutant allele was identified in 26% of the Tiryió and 30% of Waiampi samples, in 18% of the Joinville samples, and in 14% of the Salvador samples.
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spelling Distribution of the CCR2-64I allele in three Brazilian ethnic groupsCCR2-64I mutationBrazilian populationsHIV co-receptorCCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó tribe); 89 German descendents from Joinville, a city in southern Brazil; and 305 individuals of predominantly African ancestry, from Salvador, a city in northeast Brazil. The CCR2-64I mutant allele was identified in 26% of the Tiryió and 30% of Waiampi samples, in 18% of the Joinville samples, and in 14% of the Salvador samples.Sociedade Brasileira de Genética2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300004Genetics and Molecular Biology v.26 n.3 2003reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572003000300004info:eu-repo/semantics/openAccessAcosta,Angelina XavierSampaio,Rogério GrimaldiSpínola,Juliana LimaGalvão-Castro,Bernardoeng2003-09-29T00:00:00Zoai:scielo:S1415-47572003000300004Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2003-09-29T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title Distribution of the CCR2-64I allele in three Brazilian ethnic groups
spellingShingle Distribution of the CCR2-64I allele in three Brazilian ethnic groups
Acosta,Angelina Xavier
CCR2-64I mutation
Brazilian populations
HIV co-receptor
title_short Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_full Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_fullStr Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_full_unstemmed Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_sort Distribution of the CCR2-64I allele in three Brazilian ethnic groups
author Acosta,Angelina Xavier
author_facet Acosta,Angelina Xavier
Sampaio,Rogério Grimaldi
Spínola,Juliana Lima
Galvão-Castro,Bernardo
author_role author
author2 Sampaio,Rogério Grimaldi
Spínola,Juliana Lima
Galvão-Castro,Bernardo
author2_role author
author
author
dc.contributor.author.fl_str_mv Acosta,Angelina Xavier
Sampaio,Rogério Grimaldi
Spínola,Juliana Lima
Galvão-Castro,Bernardo
dc.subject.por.fl_str_mv CCR2-64I mutation
Brazilian populations
HIV co-receptor
topic CCR2-64I mutation
Brazilian populations
HIV co-receptor
description CCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó tribe); 89 German descendents from Joinville, a city in southern Brazil; and 305 individuals of predominantly African ancestry, from Salvador, a city in northeast Brazil. The CCR2-64I mutant allele was identified in 26% of the Tiryió and 30% of Waiampi samples, in 18% of the Joinville samples, and in 14% of the Salvador samples.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300004
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1415-47572003000300004
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.26 n.3 2003
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
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