Distribution of the CCR2-64I allele in three Brazilian ethnic groups

Detalhes bibliográficos
Autor(a) principal: Acosta, Angelina Xavier
Data de Publicação: 2003
Outros Autores: Sampaio, Rogério Grimaldi, Spínola, Juliana Lima, Castro, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14265
Resumo: p. 241-243
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spelling Acosta, Angelina XavierSampaio, Rogério GrimaldiSpínola, Juliana LimaCastro, Bernardo GalvãoAcosta, Angelina XavierSampaio, Rogério GrimaldiSpínola, Juliana LimaCastro, Bernardo Galvão2014-01-06T13:09:48Z2014-01-06T13:09:48Z20031415-4757http://repositorio.ufba.br/ri/handle/ri/14265v. 26, n. 3p. 241-243CCR2 is a member of the superfamily of seven transmembrane domain G protein-coupled receptors, the largest receptor superfamily in the human genome. CCR2 acts as a receptor for MCP-1 (CC chemokine) and as a co-receptor for HIV-1 cell-target entry. The gene encoding this receptor is mapped to the chromosome band 3p21. A G-to-A transition at position 190 characterizes the CCR2-64I mutation, causing valine to isoleucine substitution in codon 64. This mutation has been identified as an important factor for delaying progression to AIDS. Here, we determined the prevalence of this allele in three different Brazilian populations: 261 Amerindians inhabiting an isolated region in northern Brazil (82 samples from the Waiampi tribe, and 179 samples from the Tiriyó tribe); 89 German descendents from Joinville, a city in southern Brazil; and 305 individuals of predominantly African ancestry, from Salvador, a city in northeast Brazil. The CCR2-64I mutant allele was identified in 26% of the Tiryió and 30% of Waiampi samples, in 18% of the Joinville samples, and in 14% of the Salvador samples.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-12-16T11:58:05Z No. of bitstreams: 1 Angelina Xavier Acosta.pdf: 90711 bytes, checksum: 1dc2a96aa2013c0f4f75656b9c504c48 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-06T13:09:48Z (GMT) No. of bitstreams: 1 Angelina Xavier Acosta.pdf: 90711 bytes, checksum: 1dc2a96aa2013c0f4f75656b9c504c48 (MD5)Made available in DSpace on 2014-01-06T13:09:48Z (GMT). No. of bitstreams: 1 Angelina Xavier Acosta.pdf: 90711 bytes, checksum: 1dc2a96aa2013c0f4f75656b9c504c48 (MD5) Previous issue date: 2003http://dx.doi.org/10.1590/S1415-47572003000300004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACCR2-64I mutationBrazilian populationsHIV co-receptorDistribution of the CCR2-64I allele in three Brazilian ethnic groupsGenetics and Molecular Biologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALAngelina Xavier Acosta.pdfAngelina Xavier Acosta.pdfapplication/pdf90711https://repositorio.ufba.br/bitstream/ri/14265/1/Angelina%20Xavier%20Acosta.pdf1dc2a96aa2013c0f4f75656b9c504c48MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14265/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTAngelina Xavier Acosta.pdf.txtAngelina Xavier Acosta.pdf.txtExtracted texttext/plain14464https://repositorio.ufba.br/bitstream/ri/14265/3/Angelina%20Xavier%20Acosta.pdf.txtc1323c8e3a7097c9569f6e9da15a8ac0MD53ri/142652022-08-08 13:17:24.727oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:24Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Distribution of the CCR2-64I allele in three Brazilian ethnic groups
dc.title.alternative.pt_BR.fl_str_mv Genetics and Molecular Biology
title Distribution of the CCR2-64I allele in three Brazilian ethnic groups
spellingShingle Distribution of the CCR2-64I allele in three Brazilian ethnic groups
Acosta, Angelina Xavier
CCR2-64I mutation
Brazilian populations
HIV co-receptor
title_short Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_full Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_fullStr Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_full_unstemmed Distribution of the CCR2-64I allele in three Brazilian ethnic groups
title_sort Distribution of the CCR2-64I allele in three Brazilian ethnic groups
author Acosta, Angelina Xavier
author_facet Acosta, Angelina Xavier
Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro, Bernardo Galvão
author_role author
author2 Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro, Bernardo Galvão
author2_role author
author
author
dc.contributor.author.fl_str_mv Acosta, Angelina Xavier
Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro, Bernardo Galvão
Acosta, Angelina Xavier
Sampaio, Rogério Grimaldi
Spínola, Juliana Lima
Castro, Bernardo Galvão
dc.subject.por.fl_str_mv CCR2-64I mutation
Brazilian populations
HIV co-receptor
topic CCR2-64I mutation
Brazilian populations
HIV co-receptor
description p. 241-243
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-01-06T13:09:48Z
dc.date.available.fl_str_mv 2014-01-06T13:09:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14265
dc.identifier.issn.none.fl_str_mv 1415-4757
dc.identifier.number.pt_BR.fl_str_mv v. 26, n. 3
identifier_str_mv 1415-4757
v. 26, n. 3
url http://repositorio.ufba.br/ri/handle/ri/14265
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1415-47572003000300004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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